Human eggs made from a volunteer’s skin DNA were fertilized in the lab on September 30, 2025, and some grew for nearly a week.
A peer-reviewed study reports that early embryos formed, although most stalled because their chromosomes did not sort cleanly.
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The research was led by Shoukhrat Mitalipov, director of the OHSU Center for Embryonic Cell and Gene Therapy (OHSU) and colleagues at Oregon Health & Science University.
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The researchers used somatic cell nuclear transfer to put the nucleus from an adult skin cell into a donor human egg whose own nucleus had been removed.
[Scientists] used a body cell to reset development, proving that mature DNA can be reprogrammed to act as if it came from a newly formed egg. They then pushed this hybrid egg to act like a natural egg.
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Fertilization followed by electrical pulses and a cell cycle drug helped eggs shed extra chromosomes.
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If chromosome control can be tamed, in vitro gametogenesis (IVG) could help women who no longer have viable eggs, after cancer therapy or age-related decline.