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Anthony Santander of the Toronto Blue Jays hits a single against the Seattle Mariners during the second inning of Game 1 of the ALCS at Rogers Centre on Sunday.Mark Blinch/Getty Images

Anthony Santander’s season with the Toronto Blue Jays is over.

The Blue Jays have removed Anthony Santander from the team’s roster for the American League Championship Series versus the Seattle Mariners, due to an injury.

Just before Game 4 in Seattle, Major League Baseball announced that it had approved the Jays’ request to replace Santander on the roster with another outfielder, Joey Loperfido, for the remainder of the ALCS.

The move required the confirmation of the injury by MLB medical director Dr. Gary Green and makes the switch-hitting outfielder ineligible to return for the World Series, should the Jays get there.

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Earlier on Thursday, Jays manager John Schneider said that Santander woke up sore on Thursday.

He had been scratched from Game 2 with lower back tightness and removed from Game 3 after scoring from the second in the fifth inning.

It’s been a disappointing season for Santander, who signed a $92.5-million deal with the Jays in the offseason, but has been injured for a large chunk of this season. The franchise was looking for a slugger, after he hit a career-best 44 homers with the Baltimore Orioles in 2024.

Loperfido has been working out and traveling with the Jays throughout the series.