Sunday in San Francisco, the 49ers (6-3) host the Los Angeles Rams (6-2) with first place on the line in the NFC West.
Los Angeles blew out the Saints last week and as a result enters the game riding a three-game winning streak. Matthew Stafford is playing at an MVP level, relying heavily on star wide receiver Puka Nacua (leads the league in yards per game).
Despite a wave of injuries to key position groups, San Francisco has persevered and is right in the thick of an ultra-competitive NFC West. Somewhat ironically, running back Christian McCaffrey has remained healthy throughout the season. The All-Pro leads the NFL in yards from scrimmage.
McCaffrey and the Niners will need to be special Sunday as the Rams have held their last three opponents to 10 or fewer points.
LA is looking to become the 1st team since the 2009 Broncos to allow 10 or fewer points in 4 straight games in a season.
Fun Fact: This is the 6th time since NFL division realignment in 2002 that a division has 3 teams with 6+ wins through Week 9 (2024 NFC North, 2022 AFC East, 2022 NFC East, 2016 AFC West and 2011 AFC North).
Lets take a deeper dive into this week’s matchup between the Rams and the 49ers.
NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.
Game Details and How to watch the Rams at 49ers live SundayDate: Sunday, November 9, 2025Time: 4:25PM ESTSite: Levi’s StadiumCity: Santa Clara, CANetwork/Streaming: FOX
Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!
Game odds for the Rams at the 49ers
The latest odds as of Sunday courtesy of DraftKings:
Moneyline: Rams (-225), 49ers (+185)Spread: Rams -4.5Total: 49.5 points
This game opened at Rams -3.5 with the Game Total set at 49.0.
Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!
Bet on Mayfield, Stafford, Jackson to win NFL MVP
Matthew Berry, Jay Croucher and Connor Rogers reveal their best bets for the AP NFL Most Valuable Player award, sharing why Baker Mayfield, Matthew Stafford, Lamar Jackson have a great chance of taking home the hardware.
Quarterback Matchup for Los Angeles at San FranciscoRams Starting QB: Matthew Stafford
Last Game: 11/2 vs. New Orleans – 24-32, 281yds, 4TDs, 0INTs, Sacked 2 times, 4 carries for -4yds
Season: 8GP, 184-274, 2147yds, 21TDs, 2INTs, Sacked 13 times, 21 carries for -6yds rushing
49ers Starting QB: Mac Jones
Last Game: 11/2 at Giants – 19-24, 235yds, 2 TDs, 0INTs, Sacked 2 times, 4 carries for 4yds rushing
Season: 7GP, 168-250, 1832yds, 10TDs, 5INTs, Sacked 16 times, 27 carries for 61yds rushingRams at 49ers team stats, betting trendsThe 49ers have won their last 3 games against divisional opponentsThe Rams have covered the spread in 6 of their 8 games this seasonThe Under is 4-1 in the Rams’ last 5 gamesThe 49ers are 5-4 ATS this seasonThe Over has cashed in 5 of the 49ers 9 games this season (5-3-1)Head coaches Sean McVay (LAR) and Kyle Shanahan (SF) worked with each other on Washington’s coaching staff from 2010-13 under Kyle’s dad, Mike Shanahan
Rams Player InjuriesWR Puka Nacua (ribs) is questionable for Sunday’s gameWR Jordan Whittington (back) is questionable for Sunday’s gameCB Darious Williams (shoulder) is questionable for Sunday’s game49ers Player InjuriesRotoworld Best Bets
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Best bets our model is projecting for this week’s game between the Rams and the 49ersMoneyline: NBC Sports Bet is recommending a play on the San Francisco 49ers on the Moneyline.Spread: NBC Sports Bet is leaning towards a play ATS on the San Francisco 49ers at +4.5.Total: NBC Sports Bet is recommending a play on the under on the Game Total of 49.5.
Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!
Follow our experts on socials to keep up with all the latest content from the staff:
● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)