Computer model locks in Giants vs. Bears picks, score prediction, SGP for NFL Week 10

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The New York Giants face off with the Chicago Bears in Week 10 of the 2025 NFL season in a matchup of two teams trending in opposite directions. The Giants are trying to navigate a somewhat lost campaign thanks to injuries, but they do have a bright spot at quarterback in rookie Jaxson Dart. The Bears have rattled off five wins over their last six games and now sit a half-game back of the Green Bay Packers in the NFC North standings.

Kickoff from Soldier Field in Chicago is set for 1 p.m. ET. The Bears are 4.5-point favorites in the latest Giants vs. Bears consensus odds at SportsLine and the total is 46.5. Chicago is a -221 money line favorite while New York is a +182 underdog.

Click here to bet Giants vs. Bears at BetMGM Sportsbook, where new users get either $150 in bonus bets if your first bet wins or up to $1,500 in bonus bets if your first bet loses:

Where to bet on Giants vs. BearsWhere to watch Giants vs. Bears on Sunday

When: Sunday, Nov. 9
Time: 1 p.m. ET
TV: FOX
Stream: Fubo
Follow along: CBS Sports App

Giants vs. Bears betting preview

Odds: Bears -4.5, over/under 46.5

After losing the first two games of Ben Johnson’s tenure, the Bears have picked up steam thanks to a rejuvenated offense and a favorable schedule. Chicago is 5-3 ATS and 5-2-1 to the Over, highlighting Johnson’s ability to finally inject some life into this offense. The Giants are 4-5 ATS and 5-4 to the Over.

Click here to bet Giants vs. Bears at FanDuel Sportsbook, where new users get $300 in bonus bets if their first bet of at least $5 wins:

Giants vs. Bears SGPOver 46.5 (-112)Bears -4.5 (-110)Caleb Williams Over 1.5 passing touchdowns (-134)

Final odds: +330 at DraftKings (wager $100 to win $330)

Model’s Giants vs. Bears score prediction, picks

The Bears cover the 4.5-point spread in 63% of simulations, good for an ‘A’ grade play according to the SportsLine Projection Model, which simulates every NFL game 10,000 times. The Over hits in 49% of simulations and Chicago wins in 71% of simulations. 

Giants vs. Bears score prediction: Bears 29, Giants 19

Want more Week 10 NFL picks?

You’ve seen the model’s best bets for New York Giants vs. Chicago Bears. Now, get against the spread, total and money-line picks for every Week 10 NFL game here, all from the model that’s simulated every game 10,000 times.