Severe impacts from freezing rain are expected across portions of Louisiana and Mississippi, where ice accretions may approach 35 mm. A destructive ice storm is also expected across the Carolinas and northern Georgia, with widespread totals of 15-20 mm forecast.

Long-lasting and severe power outages are likely for many of the areas expecting freezing rain during this storm. Similar storms in the past, including in 1994 and 2002, knocked out power for 10 or more days in the hardest-hit communities.

WATCH: Large swath of U.S. prepares for destructive ice stormDisruptive snows from Oklahoma City to Boston

Farther north, cold air locked in place will make this a memorable snowstorm from Oklahoma to New England.

A widespread swath of 20-30+ cm of snow will fall across the region, with the East Coast particularly hard-hit by the growing winter storm.

US Snowfall Accumulation

Based on current forecasts, many cities will see their highest snowfall totals in a decade or more.

Heavy, blowing snow will make travel difficult or impossible on many major highways throughout the affected regions. Flight cancellations due to snow and ice topped 10,000 through Monday, according to flight tracking company FlightAware.