Just because a supplement is sold over the counter doesn’t mean it’s harmless. In fact, doctors say some of the most common vitamins and herbal supplements people take every day may come with serious health risks. From heart disease to stroke and dangerous medication interactions, certain supplements can quietly do more harm than good, especially when taken in high doses or without medical guidance.

Below, health expert Dr. Michael Lahey breaks down several popular supplements that may trigger major health complications, particularly for your heart and cardiovascular system. If you’re taking any of these — or considering adding them to your routine — this is what doctors want you to know before you pop another pill.

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1. Calcium Supplements

Calcium is undoubtedly essential. It famously plays a central role, for example, in maintaining strong bones. But when it comes to calcium supplements, caution is key. Dr. Lahey warns that “supplementing with calcium regularly can lead to hardening of arteries and heart disease.” Instead of relying on calcium pills, he suggests turning to natural sources, such as “green vegetables and dairy products,” which provide calcium without the associated cardiovascular risks. These dietary sources are not only safer but also provide a range of other nutrients that support overall health. Perfect!

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2. Vitamin E

Vitamin E is known for its antioxidant properties, which can certainly be helpful for your health. However, Dr. Lahey warns that taking it in large doses can be dangerous. “Large doses of vitamin E, greater than 400 international units a day, have been associated with hemorrhagic stroke and heart failure,” he tells us. He emphasizes that it’s better to get vitamin E from whole foods rather than supplements. “I suggest you obtain your dose of vitamin E from foods such as nuts and seeds, spinach, and such like,” he suggests. Got it!

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3. St. John’s Wort

St. John’s Wort is an herbal supplement often used as a natural remedy for depression, but it can be risky for those with heart conditions. Dr. Lahey tells us it can be especially dangerous when combined with certain medications. “The supplement should not be used if you take medicines that control heart health because it can cause dangerous interactions with blood thinners or statins,” he warns. He recommends talking to your doctor about alternative options to find safer ways to manage mood and mental health without risking harmful interactions.

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4. Bitter Orange

Bitter orange is an ingredient found in many weight loss supplements. Like ephedra and other stimulants, it can do a number on your heart. According to Dr. Lahey, “this stimulant is dangerous by raising blood pressure and causing irregular heartbeats, which are dangerous to heart patients in the elderly.” If you’re trying to shed pounds, he emphasizes that a “safe weight loss plan involves fiber intake and engaging in physical exercises.” Noted!