Michael Matthews (Jayco-AlUla) has been ruled out of the Spring Classics after breaking both his wrists in a training crash on Thursday.
The Australian had been set to line up at Paris-Nice on Sunday ahead of one of his favourite races, Milan-San Remo, which was to be followed by the cobbled Classics.
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Matthews had made a strong start to the season, winning at the first time of asking at the Gran Premio Castellón and placing third at the Trofeo Ses Salines at Challenge Mallorca.