The Cincinnati Reds battle the Pittsburgh Pirates in the second of a four-game series between National League Central rivals on Friday. Pittsburgh is coming off a 7-0 win in Thursday’s series opener. The Reds (60-56), who have dropped two in a row, are 27-30 on the road this season. The Pirates (50-66), who have won six of their past 10 games, are 33-27 on their home field in 2025.

First pitch from PNC Park in Pittsburgh is set for 6:40 p.m. ET. The Reds have won four of the past seven meetings with the Pirates. Cincinnati is a -112 favorite on the money line (risk $112 to win $100) in the latest Reds vs. Pirates odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 8. Before making any Reds vs. Pirates picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model. New users can also target the DraftKings promo code, which offers $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 20 of the 2025 MLB season a profitable 28-23 on top-rated MLB money-line picks. It has excelled making home run prop picks this season, returning nearly 60 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.    

Now, the model has set its sights on Reds vs. Pirates and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Reds vs. Pirates, which you can get in on with a DraftKings promo code or a FanDuel promo code.

Reds vs. Pirates money line

Cincinnati -112, Pittsburgh -107 at DraftKings Sportsbook

Reds vs. Pirates over/under

8 runs

Reds vs. Pirates run line 

Cincinnati -1.5 (+153)

Reds vs. Pirates picks

See picks at SportsLine

Reds vs. Pirates streaming 

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Why the Pirates can win

Pittsburgh is expected to send right-hander Mitch Keller (5-10, 3.89 ERA) to the mound. In 23 games, all starts, he has pitched 132 innings, allowing 127 hits, 62 runs – 57 earned – with 34 walks and 104 strikeouts. He is coming off a 9-5 win over the Colorado Rockies on Sunday. In that game, he pitched five innings, allowing seven hits, five earned runs and one walk, while striking out four. He took the loss in a 7-1 defeat against Cincinnati on May 19, pitching six innings, allowing six hits, one earned run and one walk, while striking out five.

Shortstop Isiah Kiner-Falefa helps power the Pittsburgh offense. In 100 games this season, he is hitting .270 with 14 doubles, two triples, 30 RBI and 34 runs scored with 14 stolen bases. He has hits in eight of the past nine games, including a 3-for-5 performance in a 17-16 loss at Colorado on Aug. 1. In that game, he added a double and three RBI. See which team to back at SportsLine.

Why the Reds can win

Right-hander Chase Burns (0-3, 6.04 ERA) is expected to get the start for Cincinnati. In seven games, all starts, Burns has logged 28.1 innings, allowing 30 hits, 22 runs – 19 earned – with 12 walks and 47 strikeouts. In a 5-2 loss to the Los Angeles Dodgers on July 28, he pitched 5.2 innings, allowing six hits, three earned runs and one walk with 10 strikeouts. In a 6-1 loss at Washington on July 22, he pitched 5.2 innings, allowing seven hits, five earned runs and two walks with 10 strikeouts.

Among Cincinnati’s top hitters this season is center fielder T.J. Friedl. In 108 games this year, he is hitting .278 with 17 doubles, two triples, 37 RBI and 64 runs scored. He has hits in nine consecutive games, with three consecutive 2-for-4 performances, including Thursday night against the Pirates. He went 5-for-12 in the previous series against the Chicago Cubs. See which team to back at SportsLine. 

How to make Reds vs. Pirates picks

SportsLine’s model is leaning Over on the total, projecting 9.6 runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks. 

So who wins Reds vs. Pirates, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.