Tuesday, April 21, 2026: Below are three of the best picks for today’s MLB slate on Underdog according to our projections team. Using factors like Statcast data, advanced sabermetrics, weather impacts, and environmental factors, every single pick is going to be based on what our projections say is a meaningful edge. Get access to all of these picks, including much more, by subscribing to the RotoGrinders Props & Pick’em package.
Don’t forget to check out our MLB weather page to see how that may impact these picks as the day progresses. And you can always stay up to date on exactly what a team’s lineup is by heading to our MLB starting lineups page.
Below, I’ll detail how I’m approaching things on Underdog for this Tuesday slate.
First… Sign Up to Make MLB Underdog Picks
If you want to play along but haven’t signed up yet, grab a special offer with our Underdog promo code to unlock a generous bonus. Underdog – one of the most popular DFS pick’em sites – provides player projections for MLB matchups each day. It is then up to the user to decide whether a player will ultimately exceed or fall short of those projections in the games. With a huge roster of players available from which to choose, we just need to make a minimum of two picks to build an entry.
When making your MLB Underdog picks today, let RotoGrinders do the heavy lifting for you!
Underdog Top MLB Picks for April 21, 2026
Now that you’re signed up, here are some of our top MLB DFS picks on Underdog for Tuesday:
Orioles vs. Royals MLB Underdog Predictions Kris Bubic lower than 6.5 Pitcher Strikeouts
The pitcher strikeouts projection for Kris Bubic looks like a strong pick based on the current data. The Underdog projection of 6.5 compares favorably based on our MLB simulations. This pick projects to hit 65.5% of the time based on the assumptions, and that represents a 7.7% edge.
Athletics vs. Mariners MLB Underdog Predictions Nick Kurtz higher than 1.5 Hits + Runs + RBIs
The hits + runs + RBIs projection for Nick Kurtz looks like a strong pick based on the current data. The Underdog projection of 1.5 compares favorably based on our MLB simulations. This pick projects to hit 57.5% of the time based on the assumptions, and that represents a 2.5% edge.
Twins vs. Mets MLB Underdog Predictions Nolan McLean lower than 17.5 Outs
The outs projection for Nolan McLean looks like a strong pick based on the current data. The Underdog projection of 17.5 compares favorably based on our MLB simulations. This pick projects to hit 55.4% of the time based on the assumptions, and that represents a 2.3% edge.
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