Toronto police say one person is dead and two others have life-threatening injuries following a suspected impaired driving crash in Scarborough.

Emergency crews were called to Sheppard Avenue and Vandorf Street, just north of Highway 401, Thursday night for a two-vehicle collision.

Police said a man in his 40s was pronounced dead at the scene, while another man in his 40s and a 35-year-old woman were taken to hospital in critical condition.

A 49-year-old man was arrested for suspected impaired driving. He has not been identified by police.

Sheppard Avenue East remains closed for an investigation.