On the next possession Lock found wide reciever Jaxon Smith-Njigba in space and last season’s offensive player of the year charged through the Patriots defence for a 45-yard touchdown.
Julian Love then picked off Patriots quarterback Maye, giving Myers the chance to edge the Seahawks in front with a 26-yard field goal.
New England were well within field-goal range with 21 seconds remaining, but chose to go for the win rather than settle for overtime, and the move backfired as Maye’s hopeful pass towards Mack Hollins was intercepted by Josh Jobe in the endzone.
The only game in which Maye threw multiple interceptions last season was the Super Bowl, and he was picked off on the Patriots’ final three possessions in the season opener.
Patriots head coach Mike Vrabel said: “You can’t throw three interceptions. Drake knows that.”
Maye said his final interception was “unacceptable”, adding: “We could have sent it to overtime at the worst, and the only thing I could do was turn the ball over.”
Seattle head coach Mike Macdonald said initial tests showed Darnold had not fractured a hip.
Week one continues with the NFL’s first regular-season game in Australia. The Los Angeles Rams meet the San Francisco 49ers in Melbourne on Thursday (01:35 BST, Friday).