New users can win big with the latest FanDuel promo code, good for $300 in bonus bets if your first wager of $5 or more wins. You can also use the latest FanDuel promo code to raise your bankroll for more NFL betting. Sports bettors can use these bonus bets on Sunday’s slate of games. 

Week 1’s NFL Sunday schedule is flooded with 13 games, and one of the SportsLine’s model best bets that showcases better value on FanDuel Sportsbook than other betting sites is the Bengals to defeat the Browns at -225 odds in the latest Week 1 NFL odds at FanDuel. Before locking in your Week 1 NFL picks on your favorite online sports betting sites like FanDuel, you’ll also want to be sure to check out the top NFL betting picks from SportsLine’s proven computer model. Pick it at FanDuel, where new users can take advantage to earn $300 in bonus bets now as a new user if your first wager of $5 or more wins at FanDuel:

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model went 31-15 on top-rated picks in 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns. Now, the model has revealed its top Week 1 NFL best bets at FanDuel Sportsbook: 

Best Week 1 NFL picks at FanDuel Sportsbook: 

Bengals money line vs. Browns (-210) Buccaneers money line vs. Falcons (-120)Dolphins (+1.5) vs. Colts (-104)

Parlay these picks for +431 odds at FanDuel Sportsbook (odds subject to change). Earn $300 in bonus bets now as a new user if your first wager of $5 or more wins at FanDuel:

Bengals money line vs. Browns (-210)

The Cincinnati Bengals narrowly missed the playoffs in 2024 with a 9-8 record, and their 1-4 start in the month of September played a massive role in that. Head coach Zac Taylor let his starters play in the preseason to avoid a slow start in 2025. Meanwhile, the Browns have Joe Flacco as the starter after drafting both Dillon Gabriel and Shedeur Sanders in the NFL draft. The Bengals were able to get Trey Hendrickson and have all their stars paid, having them ready to start things off strong. The Bengals have won four of the last five games over the Browns, including a 21-14 win at Huntington Bank Field in 2024. The model has the Bengals taking down the Browns in 67% of simulations. 

Buccaneers money line vs. Falcons (-120)

The model likes Tampa Bay here on the road against the Falcons. Even though Tampa Bay will be without Tristan Wirfs and Chris Godwin, they have the advantage at QB. Mayfield has 103 total starts under his belt, while Michael Penix only has three. The model’s simulations have the Bucs winning 66% of the time. 

Under Mayfield, Tampa Bay has won the division for two straight years. In 2024, he finished with 4,500 receiving yards and 41 passing touchdowns. He has Mike Evans in the fold, who has 11 straight 1,000-yard seasons under his belt. The Falcons were ranked 23rd in the league in total defense (345.2) and 22nd in pass defense (224.5) last season. In addition, Tampa Bay has scored at least 26 points in three straight games against the Falcons. 

Dolphins +1.5 vs. Colts (-104)

The Dolphins have their offensive unit healthy and ready to roll in this contest. Tua Tagovailoa, Tyreek Hill, Jaylen Waddle, and De’Von Achane have shown the ability to be an explosive unit when playing together and will be up against a Colts team that made Daniel Jones their starting QB. He beat out Anthony Richardson, but in six seasons, he owns a 24-44-1 record as the starter. Indianapolis’ defense was a massive letdown in 2024, ranking 29th in total defense (361.2) and 24th in scoring defense (25.1). The model projects Miami to cover the spread in 51% of simulations.

Want more Week 1 NFL picks?

You’ve seen the model’s Week 1 NFL best bets at FanDuel. Now, get against the spread, total and money-line picks for every Week 1 NFL game here, all from the model that’s simulated every game 10,000 times. 

Also at SportsLine:

You can also see Week 1 NFL picks from expert Mike Tierney, who is 61-37-3 (+2007) over his last 101 NFL ATS picks, has locked in his top Week 1 NFL picks. Visit SportsLine to see his best bets.