The Buffalo Bills are desperately searching for their first Super Bowl win, and after an AFC Championship Game exit last season, the Bills showed resolve in a come-from-behind Week 1 win over the Baltimore Ravens. Now they’ll take on a New York Jets offense that took a good Pittsburgh Steelers defense to the brink last week in an important AFC East matchup at 1 p.m. ET on Sunday. Buffalo is favored by six points in the latest Week 2 NFL odds, while the over/under for total points scored is 47.5. Other marquee matchups on the Week 2 NFL schedule include Bears at Lions (-6.5), Eagles at Chiefs (+1) and Falcons at Vikings (-3.5). 

Now that the 2025 NFL season is underway, there are plenty of NFL betting opportunities in Week 2, allowing you to scour the NFL odds from the best betting sites and apps. Here’s a closer look at the best sportsbook promos that are available for the Week 2 NFL schedule, including instructions on how to claim each offer.

Where to bet on Week 2 NFL games

The DraftKings promo code, bet365 bonus code and FanDuel promo code all offer bonus bets after new users place a wager of $5 or more. DraftKings is offering $200 in bonus bets in addition to more than $200 off NFL Sunday Ticket for the upcoming season. bet365 is offering new users either $300 in bonus bets with the placement of a $5+ bet, or up to a $1,000 first bet safety net. The FanDuel’s latest promo code offers new users $300 in bonus bets if their first bet of at least $5 wins.

Both the BetMGM bonus code and Fanatics Sportsbook promo code provide bonus bets, but only if your first bet loses. New users at Fanatics have the ability to get $100 in FanCash along with 20+ $100 No Sweat Bets in FanCash if your first football bet loses on every Game Day until October. Meanwhile, the BetMGM bonus code CBSSPORTS awards new users up to $1,500 back in bonus bets if their first bet loses. BetMGM users in New Jersey, West Virginia, Pennsylvania or Michigan can get a different promotion and receive $150 in bonus bets if you win your first bet of $10 or more. 

The Caesars Sportsbook promo code is completely different than the others, offering profit boosts instead of bonus bets. After placing a wager of $1 or more, you receive 20 100% profit boost tokens.

Bettors can use any of these promotions for any game on the Week 2 NFL schedule.

Week 2 NFL betting preview, picks

Buffalo Bills (-6) vs. New York Jets | 1 p.m. ET | Sunday, Sept. 14

Josh Allen and the Bills got the ball back down 15 with less than seven minutes to play in Week 1 against Baltimore, and Buffalo fans were streaming out of the stadium. However, he guided the team on three consecutive scoring drives to lead a miraculous 41-40 comeback victory. Allen threw for 394 yards and two touchdowns last season, and after winning NFL MVP honors in 2024, the only thing missing from his resume is a Super Bowl win. He’s won eight of his last 10 starts against the Jets, and the Bills have covered in their last three against New York. The model says Buffalo covers in 65% of simulations.

Indianapolis Colts money line (+102) vs. Denver Broncos | 4:05 p.m. ET | Sunday, Sept. 14

There has been a trend in recent years of former top picks at quarterback who were largely given up on reviving their careers elsewhere (Baker Mayfield, Sam Darnold and Geno Smith, to name a few). Could Daniel Jones be the latest entry after he led the Colts on scoring drives in every possession during his Indianapolis debut last week? The Colts outgained the Dolphins by 207 yards and won the turnover battle 3-0, and have the talent to win the AFC South if Jones holds steady. Meanwhile, Bo Nix looked like he might be the latest to follow the second-year regression trend with two interceptions and a fumble in a win over the Titans. The model says Indianapolis wins outright in 51% of simulations, outpacing the 49% implied win probability.

Over 44.5 points: Arizona Cardinals vs. Carolina Panthers | 4:05 p.m. ET | Sunday, Sept. 14

Neither team was particularly sharp through the air in Week 1, but these two teams combined for 66 points during a regular-season meeting last season, a 36-30 overtime win for Carolina. Both teams rushed for over 200 yards in that contest and averaged at least 4.5 yards per carry in Week 1 despite struggling passing attacks. Expect James Conner and Chuba Hubbard to do a lot of the heavy lifting again this season, and for the mobility of Kyler Murray and Bryce Young to play a role in a higher-than-expected scoring game. The model predicts the Over hits in 60% of simulations.

Responsible gaming

Practicing responsible gaming is paramount, which is why all the top sportsbooks have tools and resources available on their apps and websites, including time and wager limits, voluntary self-exclusion options, and more. Several are equipped with live 24/7 chat support, and all offer links and phone numbers for local and national problem gambling helplines. If you or someone you know is dealing with a gambling problem, please reach out to trained professionals such as the Problem Gambling Help Network at 1-800-GAMBLER.