He scored at 15:45 of the third period to make it 6-2.
Cole Sillinger scored his first two goals of the season and had an assist, Mathieu Olivier set a career-high with four points (one goal, three assists) for the Blue Jackets (6-4-0), who have won three straight and five of six.
Charlie Coyle had a career-best four assists, Zach Werenski had a goal and an assist and Elvis Merzlikins made 33 saves for Columbus.
Sammy Blais and Nicholas Robertson each had a goal and an assist, and Cayden Primeau made 18 saves for the Maple Leafs (5-5-1), who had won two straight.
Each team was coming off 4-3 wins on Tuesday: The Blue Jackets in overtime against the Buffalo Sabres while Toronto defeated the Calgary Flames.
Sillinger put the Blue Jackets on the board first to make it 1-0 at 6:56 in the first period. Sillinger got the wrist shot off thanks to a pass from Coyle, which marked his 300th career assist.
Werenski made it 2-0 at 11:16 with a wrist shot from the right circle. He has a goal in two straight games.
Blais batted a shot from Jake McCabe into the net with the shaft of his stick at 2:43 of the second period to make it 2-1 in his debut for the Leafs. Blais was claimed off waivers from the Montreal Canadiens on Oct. 6 and had been a scratch until tonight, as Maple Leafs’ leading scorer William Nylander did not dress due to a lower-body injury.
Ivan Provorov regained a two-goal lead making it 3-1 at 8:33. He went to the backhand in the slot to put in the rebound of a Dmitri Voronkov shot.
Sillinger increased the Blue Jackets’ lead to 4-1 at 13:24, completing a 2-on-1 with Coyle on a shot from the left circle before Fabbro made it 5-1 at 16:58.
Olivier upped it to 6-1 at 7:50 of the third period for his first of the season from a Coyle drop pass.
After the Tavares goal, Robertson scored off a wrist shot at 18:10 for the 6-3 final.