Brock Purdy is “getting closer” to returning, says San Francisco 49ers head coach Kyle Shanahan, but it likely won’t be this week. The quarterback remained limited in practice this week having not played since Week 4 after aggravating a toe injury.
“I think we’re definitely being more aggressive with him as we go this week, more aggressive than last week,” Shanahan said, via David Bonilla of 49erswebzone.com. “He’s definitely getting better each week, heading in the right direction. Still haven’t decided this week whether we’d rule him out or not. We’ll probably do that tomorrow after practice, but Brock’s definitely getting closer.”
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Shanahan added that he’s “pretty confident” Purdy will return sometime this season. Mac Jones will make his eighth start as the 49ers take on the Los Angeles Rams.
There is some good news on Jayden Daniels’ elbow. The Washington Commanders quarterback will not need surgery after an MRI revealed that he does not have any ligament damage in the elbow.
Daniels will not be placed on injured reserve, which would have ruled him out for at least an additional four weeks. The Commanders will re-evaluate the second-year quarterback following the team’s bye in Week 12.
Multiple medical opinions were sought and the Commanders believe Daniels, who is reportedly “feeling a little sore,” could possibly return at some point this season.
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Daniels was injured during Sunday night’s loss to the Seattle Seahawks. Afterward, head coach Dan Quinn said the elbow was not broken, but was unsure of a timeline for return.
Other notable Week 10 injuries:
Houston Texans quarterback C.J. Stroud will miss Week 10 after suffering a concussion last week against the Denver Broncos. Davis Mills will start in his place against the Jacksonville Jaguars.
Saquon Barkley returned to practice with the Philadelphia Eagles after suffering a groin injury against the New York Giants in Week 8. Barkley sat out the remainder of that game as a precaution and had an extra week of rest with the Eagles on a bye last week. Head coach Nick Sirianni didn’t give an update on the running back’s Week 10 status, instead deferring to the team’s injury report when it’s released on Friday.
Also back from their bye week are the Tampa Bay Buccaneers, who will not have the duo of running back Bucky Irving and wide receiver Chris Godwin Jr. for another week. Neither player practiced this week and they were ruled out Friday by head coach Todd Bowles. Godwin has missed three games with a fibula injury, while Irving has sat out four games as he deals with foot and shoulder injuries.
After missing Philadelphia’s Week 8 win over the Giants with a hamstring injury, Eagles wide receiver A.J. Brown said he expects to play Monday night against the Green Bay Packers.
Jump to a team:
AFC East: Bills | Dolphins | Patriots | Jets
AFC North: Ravens | Bengals (bye) | Browns | Steelers
AFC South: Texans | Colts | Jaguars | Titans (bye)
AFC West: Broncos (played Thurs.) | Chiefs (bye) | Raiders (played Thurs.) | Chargers
NFC East: Cowboys (bye) | Giants | Eagles | Commanders
NFC North: Bears | Lions | Packers | Vikings
NFC South: Falcons | Panthers | Saints | Buccaneers
NFC West: Cardinals | Rams | 49ers | Seahawks
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Here’s the rest of the Week 10 injury report (players will be added as teams release their reports):
ATLANTA FALCONS
EDGE Leonard Floyd (hamstring): OUT
G Matthew Bergeron (ankle): OUT
OL Storm Norton (foot): OUT
CB Mike Hughes (neck): questionable
G Chris Lindstrom (foot): questionable
DT LaCale London (shoulder): questionable
INDIANAPOLIS COLTS
DE DeForest Buckner (neck): OUT
DE Samson Ebukam (knee): OUT
DE Tyquan Lewis (groin): OUT
WR Anthony Gould (knee): questionable
JACKSONVILLE JAGUARS
WR Brian Thomas Jr. (ankle): OUT
HOUSTON TEXANS
QB C.J. Stroud (concussion): OUT
NEW ORLEANS SAINTS
RT Taliese Fuaga (ankle): OUT
RB Alvin Kamara (ankle): questionable
TE Jack Stoll (ankle): questionable
OT Barry Wesley (hip): questionable
DE Jonah Williams (shoulder): questionable
DT Bryan Bresee (back): questionable
CAROLINA PANTHERS
G Chandler Zavala (elbow): OUT
WR Brycen Tremayne (hip): questionable
WR Tetairoa McMillan (hamstring): questionable
NEW ENGLAND PATRIOTS
RB Rhamondre Stevenson (toe): OUT
WR Kayshon Boutte (hamstring): OUT
LB Christian Elliss (hip): OUT
TAMPA BAY BUCCANEERS
WR Chris Godwin Jr. (fibula): OUT
RB Bucky Irving (foot, shoulder): OUT
OLB Haason Reddick (ankle, knee): OUT
OLB Markees Watts (hand): OUT
G Luke Haggard (shoulder): questionable
T Luke Goedeke (foot): questionable
CLEVELAND BROWNS
WR Isaiah Bond (foot): OUT
WR Cedric Tillman (hamstring): questionable
TE Harold Fannin Jr. (hamstring): questionable
LB Carson Schwesinger (ankle): questionable
NEW YORK JETSBALTIMORE RAVENSMINNESOTA VIKINGS
TE Josh Oliver (foot): OUT
CB Jeff Okudah (concussion): OUT
RB Aaron Jones (shoulder/toe): questionable
S Theo Jackson (concussion): questionable
BUFFALO BILLS
DL AJ Epenesa (concussion): OUT
LB Shaq Thompson (hamstring): OUT
DT DaQuan Jones (calf): questionable
WR Josh Palmer (knee, ankle): questionable
CB Taron Johnson (groin): questionable
CB Christian Benford (groin): questionable
MIAMI DOLPHINS
WR D’Wayne Eskridge (shoulder): OUT
LB Chop Robinson (concussion): doubtful
CB Rasul Douglas (foot, ankle) doubtful
RB Ollie Gordon II (ankle): questionable
TE Julian Hill (ankle): questionable
S Ashtyn Davis (quadricep): questionable
S Ifeatu Melifonwu (thumb, foot): questionable
NEW YORK GIANTS
CB Paulson Adebo (knee): OUT
WR Beaux Collins (neck): OUT
K Graham Gano (neck): OUT
DL Chauncey Golston (neck): OUT
LB Darius Muasau (ankle): OUT
C John Michael Schmitz (shin): OUT
OLB Victor Dimukeje (shoulder): doubtful
OT Jermaine Eluemunor (pectoral): questionable
S Jevón Holland (knee): questionable
CHICAGO BEARS
DE Dominique Robinson (ankle): OUT
LB T.J. Edwards (hand, hamstring): OUT
DB Josh Blackwell (concussion): OUT
RB D’Andre Swift (groin, personal): questionable
TE Durham Smythe (calf): questionable
ARIZONA CARDINALS
QB Kyler Murray (foot): OUT
LB Mack Wilson (ribs): OUT
CB Max Melton (concussion): OUT
CB Will Johnson (back, hip): OUT
SEATTLE SEAHAWKSDETROIT LIONS
G Miles Frazier (knee): OUT
S Kerby Joseph (knee): OUT
DE Pat O’Connor (knee): OUT
DE Joshua Paschal (back): OUT
RB Jacob Saylors (back): OUT
T Taylor Decker (shoulder): questionable
RB Craig Reynolds (hamstring): questionable
LB Malcolm Rodriguez (knee): questionable
T Dan Skipper (back): questionable
LB Grant Stuard (foot): questionable
S Daniel Thomas (forearm): questionable
WASHINGTON COMMANDERS
QB Jayden Daniels (elbow): OUT
LOS ANGELES RAMSSAN FRANCISCO 49ERSPITTSBURGH STEELERSLOS ANGELES CHARGERSPHILADELPHIA EAGLESGREEN BAY PACKERSNFL injury updates liveLive8 updatesFri, November 7, 2025 at 3:29 PM EST
Andy Backstrom
Buffalo Bills running back James Cook is no longer on the injury report. He was previously listed with an ankle injury.
That means he’s good to go for Sunday’s road game against the Miami Dolphins.
Cook has crossed the century mark on the ground in five games this season.
Fri, November 7, 2025 at 3:24 PM EST
Andy Backstrom
The Jacksonville Jaguars added former Las Vegas Raiders wide receiver Jakobi Meyers at the trade deadline, and good thing they did because they’ll be down top target Brian Thomas Jr. Sunday during a pivotal AFC South showdown with the Houston Texans.
Thomas, whose production has dipped in Year 2, will be sidelined with a high ankle sprain, according to ESPN’s Adam Schefter.
Fri, November 7, 2025 at 3:17 PM EST
Andy Backstrom
The Los Angeles Rams will replace the struggling Joshua Karty with Harrison Mevis this weekend against the San Francisco 49ers, according to head coach Sean McVay, who clarified to reporters Friday that Karty is “not going anywhere.”
Karty has missed more field goal and extra point attempts this season than any kicker in the league, per ESPN’s Adam Schefter.
Mevis, who is listed at 245 pounds on the Rams’ roster, earned the nickname “Thiccer Kicker” at Missouri, where he became a first-team All-American in 2021.
Fri, November 7, 2025 at 1:19 PM EST
Sean Leahy
Shedeur Sanders will return to his role as Dillon Gabriel’s backup for Sunday’s game against the Jets.
The Browns quarterback sat out their Week 9 loss to the Patriots with tightness in his back. Following their bye last week, Sanders resumed practicing this past Wednesday.
Fri, November 7, 2025 at 1:00 PM EST
Andy Backstrom
The Indianapolis Colts announced Friday that they have placed defensive tackle DeForest Buckner on injured reserve with a neck injury.
Now that Buckner is on IR, he will have to miss a minimum of four games. The three-time Pro Bowler sustained the injury during a Week 9 loss to the Pittsburgh Steelers, according to Colts head coach Shane Steichen.
Fri, November 7, 2025 at 9:25 AM EST
Sean Leahy
Daniels suffered a dislocated elbow during last week’s loss to the Seahawks. The Commanders have yet to announce any sort of timeline for a return or if he will play again this season.
According to ESPN’s John Keim, Daniels will not need surgery on the elbow and is only “feeling a little sore.”
The Commanders have their bye in Week 12 after playing the Lions this week and the Dolphins next Sunday.
Fri, November 7, 2025 at 8:31 AM EST
Sean Leahy
Wilson suffered a knee injury during the Week 6 loss to the Broncos in London.
Fri, November 7, 2025 at 8:30 AM EST
Sean Leahy
Nacua left Sunday’s win over the Saints with a rib injury. Scans came back negative and he began the week practicing in a limited fashion. He was upgraded on Thursday and should play against the 49ers.