Jason Zucker had a goal and two assists in his return to the lineup, and six other players each had two points for the Sabres (8-9-4), who have won three of their past four games. Ukko-Pekka Luukkonen made 20 saves.
Tyler Bertuzzi scored two goals, Connor Bedard and Sam Rinzel each had two assists, and Arvid Soderblom made 21 saves for the Blackhawks (10-7-4), who have lost two in a row after a six-game point streak (5-0-1). They lost 3-2 to the Seattle Kraken on Thursday.
Doan gave Buffalo a 1-0 lead at 13:57 of the first period when he put his own rebound past Soderblom’s left pad.
Zucker, who missed eight games because of an illness, made it 2-0 at 15:19. Jack Quinn dropped a no-look backhand pass to Zucker, who snapped it over Soderblom’s arm from the left face-off circle.
Bowen Byram redirected Tuch’s diagonal cross-ice pass under Soderblom’s right arm to push the lead to 3-0 on the power play at 17:33.
Bertuzzi cut it to 3-1 at 18:12 when he backhanded a loose puck in front to the glove side.
Ryan McLeod extended the lead to 4-1 at 5:42 of the second period, putting a wrist shot under Soderblom’s right arm from the right hash marks. Eight seconds later, Mattias Samuelsson’s shot from the point went off Chicago defenseman Louis Crevier to make it 5-1 at 5:50.
Alex Vlasic beat a screened Luukkonen from above to right circle to cut it to 5-2 at 14:45.
Doan responded by scoring short side from the right circle to increase the lead to 6-2 at 17:31.
Bertuzzi tipped Bedard’s shot on the power play while screening Luukkonen to pull the Blackhawks within 6-3 at 24 seconds of the third period.
Tage Thompson then made it 7-3 at 1:56 when he drove to the net and slipped the puck under Soderblom’s pads.
Quinn roofed a wrist shot under the bar for an 8-3 lead at 7:07, and Jacob Bryson made it a 9-3 final at 16:22, getting to a loose puck in the slot and tucking it around Soderblom at the left post.