Nylander missed Toronto’s game against the Washington Capitals due to an illness, and Domi was scratched for the first time in his Maple Leafs tenure.
Along with Nylander and Domi, defenceman Philippe Myers will slot into the lineup in Simon Benoit’s spot, who flew home to attend a funeral.
Nylander leads Toronto with 31 points in 20 games this season. Domi, meanwhile, has struggled through the beginning of the year, collecting just six points in 23 contests while posting a minus-13 rating.
You can watch as the Maple Leafs look to get back in the win column on Hockey Night in Canada. Puck drop is scheduled for 7 p.m. ET / 4 p.m. PT and can be seen on Sportsnet and Sportsnet+.