Philippe Myers will slot in the lineup in Rielly’s place.
Rielly, 32, has played in 67 games for the Maple Leafs this season, with nine goals, 24 assists and a minus-17 rating.
The 13-year NHL veteran played 18:33 in the overtime defeat to Carolina, blocking four shots. It is unclear when he sustained the injury.
Myers has two assists in 34 games for Toronto in 2025-26, averaging 14:09 of ice time per contest. He last played on Tuesday against the New York Islanders.
Additionally, Berube is considering bringing Michael Pezzetta into the lineup, but said that it will be a game-time decision.
Pezzetta has played just two games for Toronto this season.