Determining the value of genomics in healthcare
Stark, Z. et al. Integrating genomics into healthcare: a global responsibility. Am. J. Hum. Genet 104, 13–20 (2019).…
Harnessing artificial intelligence to advance CRISPR-based genome editing technologies
Zheng, Y. et al. Precise genome-editing in human diseases: mechanisms, strategies and applications. Signal. Transduct. Target. Ther. 9,…
Barriers to translating continuous monitoring technologies for preventative medicine
What is Diabetes? (CDC, 2023). Harris, M. I. & Eastman, R. C. Early detection of undiagnosed diabetes mellitus:…
Statistical analysis plan for continuous positive airway pressure plus mandibular advancement therapy (PAPMAT): an adaptive randomised crossover trial comparing the benefits and costs of combining two established treatments for obstructive sleep apnoea | Trials
Timing of analysesInterim analysis The proposed interim analysis—with the purpose to perform a sample size re-estimation—will be conducted…
A full life cycle biological clock based on routine clinical data and its impact in health and diseases
Study populations The China Health Aging Investigation (CHAI), as a project of the International Consortium of Digital Twin…
Physical fitness, physical activity and screen time linked to brain development in adolescents
Physical fitness, physical activity and screen time are associated with brain mechanisms underlying mental health and learning, according…
Development and external validation of a FISH-clinical nomogram for predicting overall survival in bladder cancer patients after radical cystectomy | BMC Cancer
Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17–48. PubMed Google…
The MyCancerGene study: a hybrid type 1 effectiveness-implementation randomized study comparing a patient-centered digital genetic health portal to usual care after receipt of cancer genetic testing | BMC Cancer
Robson ME, Storm CD, Weitzel J, Wollins DS, Offit K. American society of clinical oncology policy statement update:…
Comparison of the safety and efficacy of moderately hypofractionated and conventionally fractionated radiotherapy for localized prostate cancer: evidence from 9074 men in 13 randomized clinical trials | BMC Cancer
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020:…
Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function
Institute of Medical Genetics, University of Zurich, Zurich, Switzerland Reza Asadollahi, Paranchai Boonsawat, Dennis Kraemer & Anita Rauch Faculty of Engineering and…
Cardiometabolic multimorbidity, social activity, and joint trajectories of physical disability, depressive symptom, and cognitive function in mid-to-late life: a multicohort study | BMC Medicine
Flood D, Guwatudde D, Damasceno A, Manne-Goehler J, Davies JI, Project GHP. Maximising use of population data on…
Esketamine versus sufentanil as analgesics for sedation during painless gastrointestinal endoscopy: a double-blinded randomized controlled trial | Trials
A total of 480 patients who underwent painless GI endoscopy from November 7, 2022, to April 14, 2023,…