Biomedicine - Canada News Beep

Practice of data sharing plans in clinical trial registrations and concordance between registered and published data sharing plans: a cross-sectional study | BMC Medicine

September 1, 2025

We reported this study according to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guideline [14].…

GGenetics

Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis

August 31, 2025

Ethical regulations This study was conducted under approved UKB application no. 56844. Clinical samples were obtained with informed…

GGenetics

Mutational landscape of triple-negative breast cancer in African American women

August 29, 2025

Patient population Paired tumor and normal samples from 513 self-identified AA women with TNBC were interrogated by WES.…

HHealthcare

Systematic review of cost effectiveness and budget impact of artificial intelligence in healthcare

August 28, 2025

This systematic review synthesized economic evidence from 19 diverse clinical AI interventions across multiple specialties, demonstrating consistent clinical…

HHealth

Optimizing pharmacologic treatment for neonatal opioid withdrawal syndrome (OPTimize NOW): a symptom-based dosing approach study protocol for a multi-center, cluster crossover design randomized controlled trial | Trials

August 27, 2025

Overview This section briefly describes the analysis plan that will be followed for this study. A statistical analysis…

FFitness

New perspectives on molecular mechanisms underlying exercise-induced benefits in Parkinson’s disease

August 26, 2025

Poewe, W. et al. Parkinson disease. Nat. Rev. Dis. Prim. 3, 17013 (2017). PubMed Google Scholar Stocchi, F.…

GGenetics

Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function

August 26, 2025

Ethics statement This study included de-identified data from participants who had consented to the use of their anonymized…

HHealthcare

Cost minimization analysis of digital-first healthcare pathways in primary care

August 25, 2025

In our study setting common minor acute primary care episodes initiated via a digital-first pathway were associated with…

GGenetics

Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation

August 25, 2025

Nonparametric baselines We design two nonparametric baselines that we refer to as perturbed mean and matching mean. Perturbed…

GGenetics

Precise modulation of BRG1 levels reveals features of mSWI/SNF dosage sensitivity

August 25, 2025

BRG1 binding exhibits a linear response to its dosage In mES cells, Brg1 encodes the major catalytic subunit…

GGenetics

Temporal genomic dynamics shape clinical trajectory in multiple myeloma

August 23, 2025

Maura, F. et al. Moving from cancer burden to cancer genomics for smoldering myeloma: a review. JAMA Oncol.…

HHealth

Incident arrhythmias in relation to ventilatory parameters and pulmonary disease: evidence from two prospective cohort studies | BMC Medicine

August 22, 2025

Study population The study included subjects from two cohorts, the ARIC (Atherosclerosis Risk in Communities) and the CHS…