Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas
GBD Chronic Kidney Disease Collaboration Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis…
Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression
James, S. L. et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354…
Detecting and quantifying clonal selection in somatic stem cells
Ethical approval Patient samples were collected with informed consent under the Mechanisms of Age-Related Clonal Haematopoiesis (MARCH) Study.…
Digital twins and Big AI: the future of truly individualised healthcare
Foundational Research Gaps and Future Directions for Digital Twins | National Academies. https://www.nationalacademies.org/our-work/foundational-research-gaps-and-future-directions-for-digital-twins. Coveney, P. V. & Highfield…
Predicting resistance to chemotherapy using chromosomal instability signatures
CIN signatures as biomarkers of chemotherapy resistance The presence of CIN in a tumor has long been recognized…
Pangenome analysis provides insights into legume evolution and breeding
Foyer, C. H. et al. Neglecting legumes has compromised human health and sustainable food production. Nat. Plants 2,…
Methods and applications of in vivo CRISPR screening
Auton, A. et al. A global reference for human genetic variation. Nature 526, 68–74 (2015). Google Scholar GarcÃa-GarcÃa,…
Towards improved fine-mapping of candidate causal variants
Visscher, P. M. et al. 10 years of GWAS discovery: biology, function, and translation. Am. J. Hum. Genet.…
A consensus statement on the use of digital twins in medicine
The DT is a generic instrument able to integrate different technologies applicable across the disease (and indeed health)…
Large-scale genome-wide analyses of stuttering
Yairi, E. & Ambrose, N. Epidemiology of stuttering: 21st century advances. J. Fluen. Disord. 38, 66–87 (2013). Google…
Genetic variation in the activity of a TREM2–p53 signaling axis determines oxygen-induced lung injury
Pryhuber, G. S. et al. Prematurity and respiratory outcomes program (PROP): study protocol of a prospective multicenter study…
Clinical and economic impact of a large language model in perioperative medicine: a randomized crossover trial
Study design We conducted a prospective, randomized crossover trial to evaluate the real-world clinical impact of PEACH in…