Genetic and molecular landscape of comorbidities in people living with HIV
Participants from the 2000HIV study The 2000HIV study is a prospective multicentric observational longitudinal cohort of virally suppressed…
A comparison of 27 Arabidopsis thaliana genomes and the path toward an unbiased characterization of genetic polymorphism
DNA extraction and sequencing For long-read sequencing, we began with 3-week-old plants grown in soil that had been…
Peer perceptions of clinicians using generative AI in medical decision-making
A total of 276 clinicians participated in the study, including 178 physicians, 28 fellows/residents, 60 advanced practice providers…
Tracing the evolution of sequencing into the era of genomic medicine
Sanger, F., Nicklen, S. & Coulson, A. R. DNA sequencing with chain-terminating inhibitors. Proc. Natl Acad. Sci. USA…
From gene hunter to drug hunter
Howard Chang wasn’t looking for a change from his job at Stanford, where he worked as both a…
CRISPR-GPT for agentic automation of gene-editing experiments
Building AI co-pilot harnessing LLM’s reasoning ability CRISPR-GPT supports four major gene-editing modalities and 22 gene-editing experiment tasks…
LDAK-KVIK performs fast and powerful mixed-model association analysis of quantitative and binary phenotypes
Uffelmann, E. et al. Genome-wide association studies. Nat. Rev. Methods Prim. 1, 59 (2021). CAS Google Scholar Visscher,…
Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize
Quantification of functional cis-variation To focus on genetic differences affecting TF binding in cis, we quantified TF footprints…
Functional and internalizing disorders co-aggregate with cardiometabolic and immune-related diseases within families: a population-based cohort study | BMC Medicine
Study population We analysed data from Lifelines, which is a multi-disciplinary prospective population-based cohort study examining in a…
Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas
GBD Chronic Kidney Disease Collaboration Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis…
Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression
James, S. L. et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354…
Detecting and quantifying clonal selection in somatic stem cells
Ethical approval Patient samples were collected with informed consent under the Mechanisms of Age-Related Clonal Haematopoiesis (MARCH) Study.…