New sensor captures DNA breaks, repair inside living cells in real time
In a quiet lab at Utrecht University, researchers have built a tool that lets you watch one of…
Determining the value of genomics in healthcare
Stark, Z. et al. Integrating genomics into healthcare: a global responsibility. Am. J. Hum. Genet 104, 13–20 (2019).…
Harnessing artificial intelligence to advance CRISPR-based genome editing technologies
Zheng, Y. et al. Precise genome-editing in human diseases: mechanisms, strategies and applications. Signal. Transduct. Target. Ther. 9,…
How grey hair and cancer may be linked
Grey hair is an inevitable hallmark of ageing. It’s a visual reminder of the passing years and all…
A full life cycle biological clock based on routine clinical data and its impact in health and diseases
Study populations The China Health Aging Investigation (CHAI), as a project of the International Consortium of Digital Twin…
Development and external validation of a FISH-clinical nomogram for predicting overall survival in bladder cancer patients after radical cystectomy | BMC Cancer
Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17–48. PubMed Google…
The MyCancerGene study: a hybrid type 1 effectiveness-implementation randomized study comparing a patient-centered digital genetic health portal to usual care after receipt of cancer genetic testing | BMC Cancer
Robson ME, Storm CD, Weitzel J, Wollins DS, Offit K. American society of clinical oncology policy statement update:…
Comparison of the safety and efficacy of moderately hypofractionated and conventionally fractionated radiotherapy for localized prostate cancer: evidence from 9074 men in 13 randomized clinical trials | BMC Cancer
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020:…
Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function
Institute of Medical Genetics, University of Zurich, Zurich, Switzerland Reza Asadollahi, Paranchai Boonsawat, Dennis Kraemer & Anita Rauch Faculty of Engineering and…
Modeling heterogeneity in single-cell perturbation states enhances detection of response eQTLs
Cohorts We used published data (GEO accession no. GSE162632) to study the effect of 12 h of ex vivo…
Advocate and cancer survivor Lainie Jones dies at 41 in Fort Lauderdale
Lainie Jones believed in the power of being early. She credited early detection as the reason she survived…
Genotyping sequence-resolved copy number variation using pangenomes reveals paralog-specific global diversity and expression divergence of duplicated genes
Overview of the genotyping method We represent variation as haplotype segments that are short enough to minimize disruption…