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Browsing Tag

CD4

4 posts
HHealth
Immune cells communicate across a continuous, bidirectional circuit between the CNS and periphery. Immune cells from across the body engage CNS tissues and, in turn, are shaped by signals returning from the brain. (Left) Under peripheral equilibrium, immune effectors mobilized from visceral organs, secondary lymphoid organs, hematopoietic tissues, and the peripheral nervous system (PNS) - including CD4+ and CD8+ T cells, B cells, monocytes (top 3 cell types), NK cells, dendritic cells, mast cells, neutrophils, and innate lymphoid cells (bottom cluster of cells) - engage the CNS in a homeostatic dialogue that supports neural cell health, plasticity, and repair, sustaining a protective environment. (Right) Age-associated dysfunction across the same peripheral compartments reshapes this circuit: altered immune effectors enter the CNS and contribute to shifting the local environment toward a degenerative state in which microglia adopt disease-associated programs, astrocytes become reactive, and neurons accumulate pathology. This model underscores how the same circuitry can yield protective or pathogenic outcomes and that neurodegeneration is downstream of dysfunctional brain-immune crosstalk. Study: Neurodegeneration as a dysregulation of neuroimmune crosstalk
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Disrupted brain-immune signaling may help drive neurodegeneration

  • August 24, 2026
From gut-primed T cells to microglial signaling and persistent gene-regulatory states, researchers map an intricate immune network that…
HHealth
Study: Engineering chimeric antigen receptor CD4 T cells for Alzheimer’s disease. Image Credit: Andrii Vodolazhskyi / Shutterstock
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Alzheimer’s plaques decline after CAR-T immune cell treatment in preclinical study

  • February 12, 2026
A novel CAR-T cell approach targets amyloid plaques in preclinical Alzheimer models, raising the possibility that engineered immune…
TTechnology
Engineered extracellular vesicles enable antigen-specific regulatory T cell induction
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Engineered extracellular vesicles enable antigen-specific regulatory T cell induction

  • December 23, 2025
A research team at the Nano Life Science Institute (WPI-NanoLSI) and the Faculty of Medicine at Kanazawa University…
HHealth
New study shows why HIV health recovery fails despite antiretroviral therapy
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New study shows why HIV health recovery fails despite antiretroviral therapy

  • October 3, 2025
What if the presence of a well-known but misunderstood viral protein explains why some people living with HIV…
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