Night owls who don’t respond to SSRIs: circadian rhythm core to ‘atypical’ depression mystery
About 21% of patients with depression have an atypical form that is less likely to respond to common antidepressants,…
Study explores how biological and environmental systems regulate body weight
Pennington Biomedical researchers recently investigated the systems of the body that regulate weight, exploring whether our bodies defend an established weight target or if…
Sex/gender differences in the association between behavioural factors and cancers: an umbrella review of systematic reviews with quantitative synthesis | Biology of Sex Differences
Wild CP, Weiderpass E, Stewart BW, editors. World Cancer Report: Cancer research for cancer prevention. International Agency for…
Metformin May Compromise Exercise Benefits
Metformin blunted exercise-induced improvements in vascular insulin sensitivity, aerobic fitness, inflammatory markers, and fasting glucose levels in adults…
The effects of testicular aging on Leydig cells and the application of stem cells in restoring Leydig cells function | Reproductive Biology and Endocrinology
This structured narrative review synthesized evidence identified through systematic searches of PubMed, Web of Science Core Collection, CNKI…
Women’s health research funding in Canada across 15 years suggests low funding levels with a narrow focus | Biology of Sex Differences
In total, there were 775 project grants that received CIHR funding in 2023. Seven bridge grants were removed,…
Joint association of estimated glucose disposal rate and systemic inflammation response index with all-cause and cardiovascular mortality in patients with dyslipidemia: a nationwide prospective cohort study | Diabetology & Metabolic Syndrome
Study population and data source The NHANES program, initiated by the National Center for Health Statistics (NCHS) in…
Building muscle shown to protect against obesity-related organ damage
People with excess body fat who build and keep muscle may be less likely to develop obesity-induced heart,…
Understanding sex and gender disparities in COVID-19 mortality: a narrative review beyond biology | Biology of Sex Differences
DuBois LZ, Kaiser Trujillo A, McCarthy MM. Sex and gender: toward transforming scientific practice. Cham: Springer Nature; 2025.…
SMOC1 gene plays a surprising role in the development of type 2 diabetes
Scientists at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in…
Genetic variants (LhcgrW495X/+) and environmental toxicants (DEHP) synergistically induce DSD by interfering with steroidogenic gene expression | Biology of Sex Differences
LhcgrW495X/+ male offspring showed normal phenotype and steroidogenic gene expressionLhcgrW495X/+ male offspring showed normal phenotype and steroidogenic gene…
Twenty years of progress in human exercise metabolism research
Hawley, J. A., Hargreaves, M., Joyner, M. J. & Zierath, J. R. Integrative biology of exercise. Cell 159,…