The overlapping genetic architecture of psychiatric disorders and cortical brain structure
Hyman, S. E. Can neuroscience be integrated into the DSM-V? Nat. Rev. Neurosci. 8, 725–732 (2007). Article PubMed …
Advances in haplotype phasing and genotype imputation
Voight, B. F., Kudaravalli, S., Wen, X. & Pritchard, J. K. A map of recent positive selection in…
Genetic architecture of plasma metabolome in 254,825 individuals
Population characteristics We included 254,825 UKB participants with both metabolomic and genomic data available after quality control. The…
Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects
Abul-Husn, N. S. & Kenny, E. E. Personalized medicine and the power of electronic health records. Cell 177,…
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling
Fogg, C. et al. The dynamics of frailty development and progression in older adults in primary care in…
Human Genome and Gut Fungi Interact in Chronic Disease Risk
Credit: dimdimich / Getty Images A genome-wide association study has revealed how a person’s unique genetic makeup can…
Research uncovers gene variant role in disease biology
Immune New research has filled in missing links between gene variants that have been implicated in disease through…
Research uncovers gene variant role in disease biology
New research has filled in missing links between gene variants that have been implicated in disease through genome-wide…
African American ancestry study identifies new lung cancer risk factors
Cancer Despite having lower smoking habits than other groups in the U.S., Black Americans are more likely to…
Psychiatric Disorders and Brain Structure Connected via Genetic Mapping
Credit: Floaria Bicher / iStock / Getty Images Plus Researchers have long hypothesized that the genes influencing the…
LDAK-KVIK performs fast and powerful mixed-model association analysis of quantitative and binary phenotypes
Uffelmann, E. et al. Genome-wide association studies. Nat. Rev. Methods Prim. 1, 59 (2021). CAS Google Scholar Visscher,…
Parent-of-origin effects on complex traits in up to 236,781 individuals
UK Biobank genotype processing We used the UK Biobank Axiom Array data provided in PLINK format39 and converted…