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Browsing Tag

Microglia

11 posts
HHealth
Immune cells communicate across a continuous, bidirectional circuit between the CNS and periphery. Immune cells from across the body engage CNS tissues and, in turn, are shaped by signals returning from the brain. (Left) Under peripheral equilibrium, immune effectors mobilized from visceral organs, secondary lymphoid organs, hematopoietic tissues, and the peripheral nervous system (PNS) - including CD4+ and CD8+ T cells, B cells, monocytes (top 3 cell types), NK cells, dendritic cells, mast cells, neutrophils, and innate lymphoid cells (bottom cluster of cells) - engage the CNS in a homeostatic dialogue that supports neural cell health, plasticity, and repair, sustaining a protective environment. (Right) Age-associated dysfunction across the same peripheral compartments reshapes this circuit: altered immune effectors enter the CNS and contribute to shifting the local environment toward a degenerative state in which microglia adopt disease-associated programs, astrocytes become reactive, and neurons accumulate pathology. This model underscores how the same circuitry can yield protective or pathogenic outcomes and that neurodegeneration is downstream of dysfunctional brain-immune crosstalk. Study: Neurodegeneration as a dysregulation of neuroimmune crosstalk
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Disrupted brain-immune signaling may help drive neurodegeneration

  • August 24, 2026
From gut-primed T cells to microglial signaling and persistent gene-regulatory states, researchers map an intricate immune network that…
HHealth
Why This Neurologist Says We've Been Looking at Alzheimer’s All Wrong
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Why This Neurologist Says We’ve Been Looking at Alzheimer’s All Wrong

  • July 29, 2026
For decades, researchers believed that Alzheimer’s was driven by the accumulation of harmful proteins in the brain called…
HHealth
Early warning signs of MS appear years before diagnosis and affect all communities in similar ways
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Enriched environments improve stroke recovery and reduce brain inflammation

  • April 12, 2026
Stroke is one of the leading causes of death worldwide. Its recovery is often challenging as most of…
HHealth
Lower hinge of immunoglobulin G acts as a critical immune control hub
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Investigating microglia’s role in Alzheimer’s pathology

  • March 2, 2026
Announcing a new article publication for BIO Integration journal. Alzheimer’s disease (AD) is a neurodegenerative disorder and the…
HHealth
Some Cancerous Tumors Pump Out a Protein That Seems to Destroy Alzheimer's Plaques
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Some Cancerous Tumors Pump Out a Protein That Seems to Destroy Alzheimer’s Plaques

  • February 2, 2026
Image in public domain. Cancer and Alzheimer’s are two of the most dreaded diseases, but they don’t seem…
HHealth
Brain immune cells drive persistent negative emotions after repeated binge drinking
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Brain immune cells drive persistent negative emotions after repeated binge drinking

  • January 13, 2026
New research has identified that neuroinflammation driven by microglia (immune cells in the brain) is a primary underlying…
HHealth
Neuroscience News logo for mobile.
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Hidden Early Signs of Diabetic Blindness Revealed

  • October 7, 2025
Summary: Scientists have developed a powerful new imaging method that reveals how immune cells in the eye behave…
HHealth
Microglial glycolytic reprogramming in alzheimer’s disease: association with impaired phagocytic function and altered vascular proximity | Journal of Neuroinflammation
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Microglial glycolytic reprogramming in alzheimer’s disease: association with impaired phagocytic function and altered vascular proximity | Journal of Neuroinflammation

  • October 2, 2025
In this study, we analysed HP‒EC tissue from 8 AD patients (mean age: 86.5 years, 5 males, 3…
HHealth
Senior woman by the window smelling yellow daffodil,
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Smell loss emerges as the early behavioural sign of Alzheimer’s

  • September 4, 2025
New research reveals that immune cells attack brainstem nerve fibers linked to smell, making loss of smell the…
HHealth
Spilt Salt Shaker Table
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This Everyday Food Ingredient Might Be Messing With Your Brain

  • August 28, 2025
Scientists at McGill have found that high-salt diets may trigger brain inflammation that raises blood pressure, challenging the…
HHealth
High-salt diet linked to brain inflammation that raises blood pressure
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High-salt diet linked to brain inflammation that raises blood pressure

  • August 21, 2025
A new study finds that a high-salt diet triggers brain inflammation that drives up blood pressure. The research, led…
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