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Browsing Tag

Pathology

32 posts
HHealth
Study: Oligodendrocyte dysfunction in human age-related cognitive decline. Image Credit: Lightspring / Shutterstock
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Faulty myelin-making brain cells may help drive cognitive decline with age

  • August 27, 2026
A rare combination of lifelong cognitive tracking, postmortem brain analysis, and targeted mouse experiments reveals unexpected changes in…
HHealth
Immune cells communicate across a continuous, bidirectional circuit between the CNS and periphery. Immune cells from across the body engage CNS tissues and, in turn, are shaped by signals returning from the brain. (Left) Under peripheral equilibrium, immune effectors mobilized from visceral organs, secondary lymphoid organs, hematopoietic tissues, and the peripheral nervous system (PNS) - including CD4+ and CD8+ T cells, B cells, monocytes (top 3 cell types), NK cells, dendritic cells, mast cells, neutrophils, and innate lymphoid cells (bottom cluster of cells) - engage the CNS in a homeostatic dialogue that supports neural cell health, plasticity, and repair, sustaining a protective environment. (Right) Age-associated dysfunction across the same peripheral compartments reshapes this circuit: altered immune effectors enter the CNS and contribute to shifting the local environment toward a degenerative state in which microglia adopt disease-associated programs, astrocytes become reactive, and neurons accumulate pathology. This model underscores how the same circuitry can yield protective or pathogenic outcomes and that neurodegeneration is downstream of dysfunctional brain-immune crosstalk. Study: Neurodegeneration as a dysregulation of neuroimmune crosstalk
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Disrupted brain-immune signaling may help drive neurodegeneration

  • August 24, 2026
From gut-primed T cells to microglial signaling and persistent gene-regulatory states, researchers map an intricate immune network that…
HHealth
AI model detects genetic changes in colorectal cancer from tissue images
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New genetic mutations linked to malaria drug resistance discovered

  • August 17, 2026
Researchers searching for genetic clues to the growing problem of malaria drug resistance identified new mutations associated with…
HHealth
AI and human feedback together improve neurosurgical training
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AI-based “tissue clocks” measure the biological age of human organs

  • August 14, 2026
AI-based “tissue clocks” can estimate the biological age of human organs from histological images, researchers at the CeMM…
HHealth
Using DNA sequencing for accurate identification of microbial infections in cystic fibrosis patients
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Using DNA sequencing for accurate identification of microbial infections in cystic fibrosis patients

  • August 3, 2026
Lung infections are a constant risk for people living with cystic fibrosis (CF), a life-threatening genetic disorder which…
MMedication
COVID vaccination during pregnancy not associated with neurodevelopmental problems in children
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Prenatal use of certain medications can harm developing fetal brain

  • July 21, 2026
A review article by a University of Nebraska Medical Center/Child Health Research Institute research team underscores and describes…
CCanada
Sudbury physician Dr. Kona Williams appointed to Order of Canada
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Sudbury physician Dr. Kona Williams appointed to Order of Canada

  • July 21, 2026
When Dr. Kona Williams got an email about being appointed to the Order of Canada, her first thought…
HHealth
Uncovering the secrets of ‘SuperAgers’ and cognitive longevity
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Alzheimer’s disease biomarkers predict rapid cognitive decline in very old adults

  • July 1, 2026
Cognitive decline in very old adults has been considered for decades to be an almost inevitable consequence of…
HHealth
Study finds association between groundwater age and Parkinson’s risk
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Women with Parkinson’s may be more vulnerable to Alzheimer’s pathology

  • June 29, 2026
Women with Parkinson’s disease may be more vulnerable to Alzheimer’s-related changes in the brain than men, according to…
HHealth
'Exciting' Clinical Trial Results For New Endometriosis Scan
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‘Exciting’ Clinical Trial Results For New Endometriosis Scan

  • June 27, 2026
Doctors working on the first non-invasive diagnostic test for endometriosis have published the results of the DETECT phase 2…
HHealth
Study: Associations of stable psychological traits with multi-omic subtypes of Alzheimer’s dementia. Image Credit: Inna Kot / Shutterstock
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Psychological traits may uncover why Alzheimer’s biology differs between patients

  • June 23, 2026
A postmortem multi-omics study suggests that long-standing traits such as neuroticism, loneliness, and purpose in life may track…
HHealth
Uncovering the secrets of ‘SuperAgers’ and cognitive longevity
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Retinal photographs may reveal early Alzheimer’s disease risk

  • June 17, 2026
Often called “the window to the soul,” the eyes may also offer clues about something less poetic but…
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