{"id":125780,"date":"2025-09-07T04:29:06","date_gmt":"2025-09-07T04:29:06","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/125780\/"},"modified":"2025-09-07T04:29:06","modified_gmt":"2025-09-07T04:29:06","slug":"picks-and-predictions-for-week-1-vs-the-san-francisco-49ers","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/125780\/","title":{"rendered":"Picks And Predictions For Week 1 vs. the San Francisco 49ers"},"content":{"rendered":"<p>The Seattle Seahawks (0-0) take on the San Francisco 49ers (0-0) for Week 1 at Lumen Field. Take a look at what local and national media are predicting for Sunday&#8217;s game. <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.seahawks.com\/news\/2025-week-1-seahawks-vs-49ers-how-to-watch-september-7\" target=\"_blank\" rel=\"nofollow noopener\">Click here to learn how to watch, listen, and stream the action.<\/a><\/p>\n<p>Mike Vorel, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.seattletimes.com\/sports\/seahawks\/seattle-times-staff-picks-for-seahawks-vs-49ers-in-week-1\/\" target=\"_blank\" rel=\"nofollow noopener\">Seattle Times:<\/a> Seahawks 24, 49ers 20<\/p>\n<p>&#8220;NFL teams are never as good as their offseason narrative. But in this case, I believe the Seahawks&#8217; offensive reinvention will pay dividends in the season opener against San Francisco. The running game will be effective enough, quarterback Sam Darnold will avoid fatal mistakes and the Seahawks&#8217; defense will maintain its momentum from late last season. Seattle&#8217;s 2025 season will start with a big NFC West win.&#8221;<\/p>\n<p>Bob Condotta, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.seattletimes.com\/sports\/seahawks\/seattle-times-staff-picks-for-seahawks-vs-49ers-in-week-1\/\" target=\"_blank\" rel=\"nofollow noopener\">Seattle Times:<\/a> Seahawks 23, 49ers 17<\/p>\n<p>&#8220;It feels like there&#8217;s a lot on the line as the Seahawks begin the second year of the Mike Macdonald era. It also feels like there&#8217;s lots of room for optimism \u2014 a revived offensive line powering an improved running game, a defense that may be better than people expect. The Seahawks also got the 49ers monkey off their back with the win last November. A fevered home crowd helps lift Seattle to a critical win.&#8221;<\/p>\n<p>Matt Calkins, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.seattletimes.com\/sports\/seahawks\/seattle-times-staff-picks-for-seahawks-vs-49ers-in-week-1\/\" target=\"_blank\" rel=\"nofollow noopener\">Seattle Times:<\/a> 49ers 20, Seahawks 17<\/p>\n<p>Seattle&#8217;s defense will slow down a Niners squad trying to bounce back from its Super Bowl hangover year, but the new-look offense will struggle in the season-opener and won&#8217;t do enough to get the W.<\/p>\n<p>Tim Booth, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.seattletimes.com\/sports\/seahawks\/seattle-times-staff-picks-for-seahawks-vs-49ers-in-week-1\/\" target=\"_blank\" rel=\"nofollow noopener\">Seattle Times:<\/a> Seahawks 23, 49ers 17<\/p>\n<p>&#8220;The streak must end at some point, right, as the 49ers have won their last three visits to Lumen Field. But there are seemingly more questions about the Niners than there are about the Seahawks entering this opener, even if San Francisco has as much talent as any other team in the NFC West. A late Sam Darnold-to-Cooper Kupp TD pass proves to be the difference.&#8221;<\/p>\n<p>Bill Bender, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.sportingnews.com\/us\/nfl\/news\/nfl-picks-predictions-week-1\/f9551471d0936c2bbf580cb8\" target=\"_blank\" rel=\"nofollow noopener\">Sporting News:<\/a> 49ers 28, Seahawks 21<\/p>\n<p>&#8220;The Seahawks begin the Sam Darnold era, and the 49ers look to bounce back after an injury-riddled season a year ago. Brock Purdy now has the benefit of a backfield that features Christian McCaffrey and Brian Robinson Jr., and the 49ers have won the last three matchups at Seattle. Look for that streak to continue.&#8221;<\/p>\n<p>Pete Prisco, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.cbssports.com\/nfl\/news\/priscos-week-1-nfl-picks-bills-outlast-ravens-jets-beat-aaron-rodgers-and-bears-ruin-j-j-mccarthys-debut\/\" target=\"_blank\" rel=\"nofollow noopener\">CBS Sports:<\/a> 49ers 23, Seahawks 17<\/p>\n<p>&#8220;The 49ers have won seven of the last eight in this series, but Seattle won the last one last November. These teams are a lot different now. The 49ers were banged up last year, but Christian McCaffrey and left tackle Trent Williams are two of their stars who are back. That will matter. The Seahawks will have Sam Darnold making his first start at quarterback. It&#8217;s always tough to play at Seattle, but the 49ers know how to win there. They will again.&#8221;<\/p>\n<p>More Picks From Around The Web<\/p>\n<p>Seth Walder, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.espn.com\/nfl\/story\/_\/id\/46139433\/nfl-week-1-picks-predictions-schedule-fantasy-football-odds-injuries-stats-2025\" target=\"_blank\" rel=\"nofollow noopener\">ESPN:<\/a> Seahawks 24, 49ers 23<\/p>\n<p>Eric Moody, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.espn.com\/nfl\/picks\" target=\"_blank\" rel=\"nofollow noopener\">ESPN:<\/a> 49ers 27, Seahawks 23<\/p>\n<p>Pamela Maldonado, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.espn.com\/nfl\/picks\" target=\"_blank\" rel=\"nofollow noopener\">ESPN:<\/a> 49ers 27, Seahawks 17<\/p>\n<p>Mike Florio, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.nbcsports.com\/nfl\/profootballtalk\/rumor-mill\/news\/pfts-week-1-2025-nfl-picks-florio-vs-simms\" target=\"_blank\" rel=\"nofollow noopener\">NBC Sports:<\/a> 49ers 27, Seahawks 20<\/p>\n<p>Chris Simms, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" href=\"https:\/\/www.nbcsports.com\/nfl\/profootballtalk\/rumor-mill\/news\/pfts-week-14-2024-nfl-picks-florio-vs-simms\" rel=\"nofollow noopener\" target=\"_blank\"> <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.nbcsports.com\/nfl\/profootballtalk\/rumor-mill\/news\/pfts-week-1-2025-nfl-picks-florio-vs-simms\" target=\"_blank\" rel=\"nofollow noopener\">NBC Sports:<\/a> Seahawks 23, 49ers 20<\/p>\n<p>Ali Bhanpuri, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.nfl.com\/news\/nfl-picks-week-1-2025-nfl-season\" target=\"_blank\" rel=\"nofollow noopener\">NFL.com:<\/a> 49ers 23, Seahawks 20<\/p>\n<p>Brooke Cersosimo <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.nfl.com\/news\/nfl-picks-week-1-2025-nfl-season\" target=\"_blank\" rel=\"nofollow noopener\">NFL.com:<\/a> 49ers 26, Seahawks 21<\/p>\n<p>Dan Parr, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.nfl.com\/news\/nfl-picks-week-1-2025-nfl-season\" target=\"_blank\" rel=\"nofollow noopener\">NFL.com:<\/a> 49ers 21, Seahawks 20<\/p>\n<p>Gennaro Filice, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.nfl.com\/news\/nfl-picks-week-1-2025-nfl-season\" target=\"_blank\" rel=\"nofollow noopener\">NFL.com:<\/a> Seahawks 22, 49ers 20<\/p>\n<p>Tom Blair, <a class=\"nfl-o-cta--link nfl-o-cta--underline\" style=\"word-break: break-word\" href=\"https:\/\/www.nfl.com\/news\/nfl-picks-week-1-2025-nfl-season\" target=\"_blank\" rel=\"nofollow noopener\">NFL.com:<\/a> 49ers 23, Seahawks 20<\/p>\n","protected":false},"excerpt":{"rendered":"The Seattle Seahawks (0-0) take on the San Francisco 49ers (0-0) for Week 1 at Lumen Field. Take&hellip;\n","protected":false},"author":2,"featured_media":125781,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[49,48,61732,61731,69273,61730,69274,82],"class_list":["post-125780","post","type-post","status-publish","format-standard","has-post-thumbnail","category-sports","tag-ca","tag-canada","tag-homepage-hero","tag-news-national-feature","tag-news-picks-and-predictions","tag-news-stories","tag-san-francisco-49ers-at-seattle-seahawks-2025-reg-1","tag-sports"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/125780","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=125780"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/125780\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/125781"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=125780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=125780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=125780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}