{"id":142151,"date":"2025-09-14T00:04:07","date_gmt":"2025-09-14T00:04:07","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/142151\/"},"modified":"2025-09-14T00:04:07","modified_gmt":"2025-09-14T00:04:07","slug":"higher-phq-9-score-levels-and-neutrophil-to-lymphocyte-ratio-are-associated-with-increased-risks-of-stroke-all-cause-mortality-and-mace-in-nhanes-2005-2018-bmc-psychiatry","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/142151\/","title":{"rendered":"Higher PHQ-9 score levels and neutrophil-to-lymphocyte ratio are associated with increased risks of stroke, all-cause mortality, and MACE in NHANES 2005\u20132018 | BMC Psychiatry"},"content":{"rendered":"<p class=\"c-article-references__text\" id=\"ref-CR1\">Diseases GBD, Injuries C. Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet (London, England). 2020;396(10258):1204\u201322.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S0140-6736(20)30925-9\" data-track-item_id=\"10.1016\/S0140-6736(20)30925-9\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS0140-6736%2820%2930925-9\" aria-label=\"Article reference 1\" data-doi=\"10.1016\/S0140-6736(20)30925-9\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 1\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Global%20burden%20of%20369%20diseases%20and%20injuries%20in%20204%20countries%20and%20territories%2C%201990%E2%80%932019%3A%20a%20systematic%20analysis%20for%20the%20Global%20Burden%20of%20Disease%20Study%202019&amp;journal=Lancet%20%28London%2C%20England%29&amp;doi=10.1016%2FS0140-6736%2820%2930925-9&amp;volume=396&amp;issue=10258&amp;pages=1204-1222&amp;publication_year=2020&amp;author=Diseases%2CGBD&amp;author=Injuries%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR2\">Jayaraj RL, Azimullah S, Beiram R, Jalal FY, Rosenberg GA. Neuroinflammation: friend and foe for ischemic stroke. J Neuroinflammation. 2019;16(1):142.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1186\/s12974-019-1516-2\" data-track-item_id=\"10.1186\/s12974-019-1516-2\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1186\/s12974-019-1516-2\" aria-label=\"Article reference 2\" data-doi=\"10.1186\/s12974-019-1516-2\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31291966\" aria-label=\"PubMed reference 2\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6617684\" aria-label=\"PubMed Central reference 2\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 2\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neuroinflammation%3A%20friend%20and%20foe%20for%20ischemic%20stroke&amp;journal=J%20Neuroinflammation&amp;doi=10.1186%2Fs12974-019-1516-2&amp;volume=16&amp;issue=1&amp;publication_year=2019&amp;author=Jayaraj%2CRL&amp;author=Azimullah%2CS&amp;author=Beiram%2CR&amp;author=Jalal%2CFY&amp;author=Rosenberg%2CGA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR3\">Moro-Garcia MA, Mayo JC, Sainz RM, Alonso-Arias R. Influence of inflammation in the process of T lymphocyte differentiation: proliferative, metabolic, and oxidative changes. Front Immunol. 2018;9:339.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3389\/fimmu.2018.00339\" data-track-item_id=\"10.3389\/fimmu.2018.00339\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3389%2Ffimmu.2018.00339\" aria-label=\"Article reference 3\" data-doi=\"10.3389\/fimmu.2018.00339\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=29545794\" aria-label=\"PubMed reference 3\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5839096\" aria-label=\"PubMed Central reference 3\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 3\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Influence%20of%20inflammation%20in%20the%20process%20of%20T%20lymphocyte%20differentiation%3A%20proliferative%2C%20metabolic%2C%20and%20oxidative%20changes&amp;journal=Front%20Immunol&amp;doi=10.3389%2Ffimmu.2018.00339&amp;volume=9&amp;publication_year=2018&amp;author=Moro-Garcia%2CMA&amp;author=Mayo%2CJC&amp;author=Sainz%2CRM&amp;author=Alonso-Arias%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR4\">Castanheira FVS, Kubes P. Neutrophils and NETs in modulating acute and chronic inflammation. Blood. 2019;133(20):2178\u201385.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1182\/blood-2018-11-844530\" data-track-item_id=\"10.1182\/blood-2018-11-844530\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1182%2Fblood-2018-11-844530\" aria-label=\"Article reference 4\" data-doi=\"10.1182\/blood-2018-11-844530\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhtFaht7jO\" aria-label=\"CAS reference 4\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30898862\" aria-label=\"PubMed reference 4\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 4\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neutrophils%20and%20NETs%20in%20modulating%20acute%20and%20chronic%20inflammation&amp;journal=Blood&amp;doi=10.1182%2Fblood-2018-11-844530&amp;volume=133&amp;issue=20&amp;pages=2178-2185&amp;publication_year=2019&amp;author=Castanheira%2CFVS&amp;author=Kubes%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR5\">Cao X, Zhu Q, Xia X, Yao B, Liang S, Chen Z, et al. The correlation between novel peripheral blood cell ratios and 90-day mortality in patients with acute ischemic stroke. PLoS ONE. 2020;15(8): e0238312.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1371\/journal.pone.0238312\" data-track-item_id=\"10.1371\/journal.pone.0238312\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1371%2Fjournal.pone.0238312\" aria-label=\"Article reference 5\" data-doi=\"10.1371\/journal.pone.0238312\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhslCgt7rL\" aria-label=\"CAS reference 5\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32857820\" aria-label=\"PubMed reference 5\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7454963\" aria-label=\"PubMed Central reference 5\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 5\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20correlation%20between%20novel%20peripheral%20blood%20cell%20ratios%20and%2090-day%20mortality%20in%20patients%20with%20acute%20ischemic%20stroke&amp;journal=PLoS%20ONE&amp;doi=10.1371%2Fjournal.pone.0238312&amp;volume=15&amp;issue=8&amp;publication_year=2020&amp;author=Cao%2CX&amp;author=Zhu%2CQ&amp;author=Xia%2CX&amp;author=Yao%2CB&amp;author=Liang%2CS&amp;author=Chen%2CZ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR6\">Ma F, Li L, Xu L, Wu J, Zhang A, Liao J, et al. The relationship between systemic inflammation index, systemic immune-inflammatory index, and inflammatory prognostic index and 90-day outcomes in acute ischemic stroke patients treated with intravenous thrombolysis. J Neuroinflamm. 2023;20(1):220.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1186\/s12974-023-02890-y\" data-track-item_id=\"10.1186\/s12974-023-02890-y\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1186\/s12974-023-02890-y\" aria-label=\"Article reference 6\" data-doi=\"10.1186\/s12974-023-02890-y\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXitVeltLbL\" aria-label=\"CAS reference 6\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 6\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20relationship%20between%20systemic%20inflammation%20index%2C%20systemic%20immune-inflammatory%20index%2C%20and%20inflammatory%20prognostic%20index%20and%2090-day%20outcomes%20in%20acute%20ischemic%20stroke%20patients%20treated%20with%20intravenous%20thrombolysis&amp;journal=J%20Neuroinflamm&amp;doi=10.1186%2Fs12974-023-02890-y&amp;volume=20&amp;issue=1&amp;publication_year=2023&amp;author=Ma%2CF&amp;author=Li%2CL&amp;author=Xu%2CL&amp;author=Wu%2CJ&amp;author=Zhang%2CA&amp;author=Liao%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR7\">Zhang A, Zhu Y, Liao J, Wu D, Yan X, Chen J, et al. The association of systemic inflammatory response index and neutrophil-to-high-density lipoprotein ratio mediated by fasting blood glucose with 90-day prognosis in acute ischemic stroke patients. Neuroepidemiology. 2024;15:1\u201312.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 7\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20association%20of%20systemic%20inflammatory%20response%20index%20and%20neutrophil-to-high-density%20lipoprotein%20ratio%20mediated%20by%20fasting%20blood%20glucose%20with%2090-day%20prognosis%20in%20acute%20ischemic%20stroke%20patients&amp;journal=Neuroepidemiology&amp;volume=15&amp;pages=1-12&amp;publication_year=2024&amp;author=Zhang%2CA&amp;author=Zhu%2CY&amp;author=Liao%2CJ&amp;author=Wu%2CD&amp;author=Yan%2CX&amp;author=Chen%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR8\">Zhang T, Fu S, Cao X, Xia Y, Hu M, Feng Q, et al. Correlation of peripheral blood inflammatory indicators to prognosis after intravenous thrombolysis in acute ischemic stroke: a retrospective study. Int J Gen Med. 2024;17:985\u201396.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.2147\/IJGM.S456144\" data-track-item_id=\"10.2147\/IJGM.S456144\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.2147%2FIJGM.S456144\" aria-label=\"Article reference 8\" data-doi=\"10.2147\/IJGM.S456144\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38505143\" aria-label=\"PubMed reference 8\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10949996\" aria-label=\"PubMed Central reference 8\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 8\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Correlation%20of%20peripheral%20blood%20inflammatory%20indicators%20to%20prognosis%20after%20intravenous%20thrombolysis%20in%20acute%20ischemic%20stroke%3A%20a%20retrospective%20study&amp;journal=Int%20J%20Gen%20Med&amp;doi=10.2147%2FIJGM.S456144&amp;volume=17&amp;pages=985-996&amp;publication_year=2024&amp;author=Zhang%2CT&amp;author=Fu%2CS&amp;author=Cao%2CX&amp;author=Xia%2CY&amp;author=Hu%2CM&amp;author=Feng%2CQ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR9\">Kelly PJ, Lemmens R, Tsivgoulis G. Inflammation and stroke risk: a new target for prevention. Stroke. 2021;52(8):2697\u2013706.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1161\/STROKEAHA.121.034388\" data-track-item_id=\"10.1161\/STROKEAHA.121.034388\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1161%2FSTROKEAHA.121.034388\" aria-label=\"Article reference 9\" data-doi=\"10.1161\/STROKEAHA.121.034388\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34162215\" aria-label=\"PubMed reference 9\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 9\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inflammation%20and%20stroke%20risk%3A%20a%20new%20target%20for%20prevention&amp;journal=Stroke&amp;doi=10.1161%2FSTROKEAHA.121.034388&amp;volume=52&amp;issue=8&amp;pages=2697-2706&amp;publication_year=2021&amp;author=Kelly%2CPJ&amp;author=Lemmens%2CR&amp;author=Tsivgoulis%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR10\">Deftereos SG, Beerkens FJ, Shah B, Giannopoulos G, Vrachatis DA, Giotaki SG, et al. Colchicine in Cardiovascular Disease: In-Depth Review. Circulation. 2022;145(1):61\u201378.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1161\/CIRCULATIONAHA.121.056171\" data-track-item_id=\"10.1161\/CIRCULATIONAHA.121.056171\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1161%2FCIRCULATIONAHA.121.056171\" aria-label=\"Article reference 10\" data-doi=\"10.1161\/CIRCULATIONAHA.121.056171\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXivValtr7O\" aria-label=\"CAS reference 10\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34965168\" aria-label=\"PubMed reference 10\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 10\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Colchicine%20in%20Cardiovascular%20Disease%3A%20In-Depth%20Review&amp;journal=Circulation&amp;doi=10.1161%2FCIRCULATIONAHA.121.056171&amp;volume=145&amp;issue=1&amp;pages=61-78&amp;publication_year=2022&amp;author=Deftereos%2CSG&amp;author=Beerkens%2CFJ&amp;author=Shah%2CB&amp;author=Giannopoulos%2CG&amp;author=Vrachatis%2CDA&amp;author=Giotaki%2CSG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR11\">Celikbilek A, Ismailogullari S, Zararsiz G. Neutrophil to lymphocyte ratio predicts poor prognosis in ischemic cerebrovascular disease. J Clin Lab Anal. 2014;28(1):27\u201331.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/jcla.21639\" data-track-item_id=\"10.1002\/jcla.21639\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2Fjcla.21639\" aria-label=\"Article reference 11\" data-doi=\"10.1002\/jcla.21639\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2cXpsF2ltQ%3D%3D\" aria-label=\"CAS reference 11\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24375839\" aria-label=\"PubMed reference 11\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 11\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neutrophil%20to%20lymphocyte%20ratio%20predicts%20poor%20prognosis%20in%20ischemic%20cerebrovascular%20disease&amp;journal=J%20Clin%20Lab%20Anal&amp;doi=10.1002%2Fjcla.21639&amp;volume=28&amp;issue=1&amp;pages=27-31&amp;publication_year=2014&amp;author=Celikbilek%2CA&amp;author=Ismailogullari%2CS&amp;author=Zararsiz%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR12\">Giede-Jeppe A, Reichl J, Sprugel MI, Lucking H, Hoelter P, Eyupoglu IY, et al. Neutrophil-to-lymphocyte ratio as an independent predictor for unfavorable functional outcome in aneurysmal subarachnoid hemorrhage. J Neurosurg. 2019;132(2):400\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3171\/2018.9.JNS181975\" data-track-item_id=\"10.3171\/2018.9.JNS181975\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3171%2F2018.9.JNS181975\" aria-label=\"Article reference 12\" data-doi=\"10.3171\/2018.9.JNS181975\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30717052\" aria-label=\"PubMed reference 12\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 12\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neutrophil-to-lymphocyte%20ratio%20as%20an%20independent%20predictor%20for%20unfavorable%20functional%20outcome%20in%20aneurysmal%20subarachnoid%20hemorrhage&amp;journal=J%20Neurosurg&amp;doi=10.3171%2F2018.9.JNS181975&amp;volume=132&amp;issue=2&amp;pages=400-407&amp;publication_year=2019&amp;author=Giede-Jeppe%2CA&amp;author=Reichl%2CJ&amp;author=Sprugel%2CMI&amp;author=Lucking%2CH&amp;author=Hoelter%2CP&amp;author=Eyupoglu%2CIY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR13\">Quan K, Wang A, Zhang X, Meng X, Chen P, Li H, et al. Neutrophil to lymphocyte ratio and adverse clinical outcomes in patients with ischemic stroke. Ann Transl Med. 2021;9(13):1047.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.21037\/atm-21-710\" data-track-item_id=\"10.21037\/atm-21-710\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.21037%2Fatm-21-710\" aria-label=\"Article reference 13\" data-doi=\"10.21037\/atm-21-710\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34422959\" aria-label=\"PubMed reference 13\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8339844\" aria-label=\"PubMed Central reference 13\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 13\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neutrophil%20to%20lymphocyte%20ratio%20and%20adverse%20clinical%20outcomes%20in%20patients%20with%20ischemic%20stroke&amp;journal=Ann%20Transl%20Med&amp;doi=10.21037%2Fatm-21-710&amp;volume=9&amp;issue=13&amp;publication_year=2021&amp;author=Quan%2CK&amp;author=Wang%2CA&amp;author=Zhang%2CX&amp;author=Meng%2CX&amp;author=Chen%2CP&amp;author=Li%2CH\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR14\">Jiang L, Cai X, Yao D, Jing J, Mei L, Yang Y, et al. Association of inflammatory markers with cerebral small vessel disease in community-based population. J Neuroinflammation. 2022;19(1):106.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1186\/s12974-022-02468-0\" data-track-item_id=\"10.1186\/s12974-022-02468-0\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1186\/s12974-022-02468-0\" aria-label=\"Article reference 14\" data-doi=\"10.1186\/s12974-022-02468-0\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38Xhtlajsb%2FM\" aria-label=\"CAS reference 14\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35513834\" aria-label=\"PubMed reference 14\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9072153\" aria-label=\"PubMed Central reference 14\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 14\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Association%20of%20inflammatory%20markers%20with%20cerebral%20small%20vessel%20disease%20in%20community-based%20population&amp;journal=J%20Neuroinflammation&amp;doi=10.1186%2Fs12974-022-02468-0&amp;volume=19&amp;issue=1&amp;publication_year=2022&amp;author=Jiang%2CL&amp;author=Cai%2CX&amp;author=Yao%2CD&amp;author=Jing%2CJ&amp;author=Mei%2CL&amp;author=Yang%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR15\">Kim MS, Heo MY, Joo HJ, Shim GY, Chon J, Chung SJ, et al. Neutrophil-to-lymphocyte ratio as a predictor of short-term functional outcomes in acute ischemic stroke patients. Int J Environ Res Public Health. 2023;20(2):898.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/ijerph20020898\" data-track-item_id=\"10.3390\/ijerph20020898\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fijerph20020898\" aria-label=\"Article reference 15\" data-doi=\"10.3390\/ijerph20020898\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3sXitFWrsbw%3D\" aria-label=\"CAS reference 15\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36673655\" aria-label=\"PubMed reference 15\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9859224\" aria-label=\"PubMed Central reference 15\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 15\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neutrophil-to-lymphocyte%20ratio%20as%20a%20predictor%20of%20short-term%20functional%20outcomes%20in%20acute%20ischemic%20stroke%20patients&amp;journal=Int%20J%20Environ%20Res%20Public%20Health&amp;doi=10.3390%2Fijerph20020898&amp;volume=20&amp;issue=2&amp;publication_year=2023&amp;author=Kim%2CMS&amp;author=Heo%2CMY&amp;author=Joo%2CHJ&amp;author=Shim%2CGY&amp;author=Chon%2CJ&amp;author=Chung%2CSJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR16\">Ferrari AJ, Charlson FJ, Norman RE, Patten SB, Freedman G, Murray CJ, et al. Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoS Med. 2013;10(11): e1001547.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1371\/journal.pmed.1001547\" data-track-item_id=\"10.1371\/journal.pmed.1001547\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1371%2Fjournal.pmed.1001547\" aria-label=\"Article reference 16\" data-doi=\"10.1371\/journal.pmed.1001547\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24223526\" aria-label=\"PubMed reference 16\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3818162\" aria-label=\"PubMed Central reference 16\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 16\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Burden%20of%20depressive%20disorders%20by%20country%2C%20sex%2C%20age%2C%20and%20year%3A%20findings%20from%20the%20global%20burden%20of%20disease%20study%202010&amp;journal=PLoS%20Med&amp;doi=10.1371%2Fjournal.pmed.1001547&amp;volume=10&amp;issue=11&amp;publication_year=2013&amp;author=Ferrari%2CAJ&amp;author=Charlson%2CFJ&amp;author=Norman%2CRE&amp;author=Patten%2CSB&amp;author=Freedman%2CG&amp;author=Murray%2CCJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR17\">Schulz R, Drayer RA, Rollman BL. Depression as a risk factor for non-suicide mortality in the elderly. Biol Psychiatry. 2002;52(3):205\u201325.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/S0006-3223(02)01423-3\" data-track-item_id=\"10.1016\/S0006-3223(02)01423-3\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2FS0006-3223%2802%2901423-3\" aria-label=\"Article reference 17\" data-doi=\"10.1016\/S0006-3223(02)01423-3\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=12182927\" aria-label=\"PubMed reference 17\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 17\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Depression%20as%20a%20risk%20factor%20for%20non-suicide%20mortality%20in%20the%20elderly&amp;journal=Biol%20Psychiatry&amp;doi=10.1016%2FS0006-3223%2802%2901423-3&amp;volume=52&amp;issue=3&amp;pages=205-225&amp;publication_year=2002&amp;author=Schulz%2CR&amp;author=Drayer%2CRA&amp;author=Rollman%2CBL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR18\">Li H, Zheng D, Li Z, Wu Z, Feng W, Cao X, et al. Association of depressive symptoms with incident cardiovascular diseases in middle-aged and older Chinese adults. JAMA Netw Open. 2019;2(12): e1916591.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1001\/jamanetworkopen.2019.16591\" data-track-item_id=\"10.1001\/jamanetworkopen.2019.16591\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1001%2Fjamanetworkopen.2019.16591\" aria-label=\"Article reference 18\" data-doi=\"10.1001\/jamanetworkopen.2019.16591\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31800066\" aria-label=\"PubMed reference 18\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6902756\" aria-label=\"PubMed Central reference 18\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 18\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Association%20of%20depressive%20symptoms%20with%20incident%20cardiovascular%20diseases%20in%20middle-aged%20and%20older%20Chinese%20adults&amp;journal=JAMA%20Netw%20Open&amp;doi=10.1001%2Fjamanetworkopen.2019.16591&amp;volume=2&amp;issue=12&amp;publication_year=2019&amp;author=Li%2CH&amp;author=Zheng%2CD&amp;author=Li%2CZ&amp;author=Wu%2CZ&amp;author=Feng%2CW&amp;author=Cao%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR19\">Harshfield EL, Pennells L, Schwartz JE, Willeit P, Kaptoge S, Bell S, et al. Association between depressive symptoms and incident cardiovascular diseases. JAMA. 2020;324(23):2396\u2013405.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1001\/jama.2020.23068\" data-track-item_id=\"10.1001\/jama.2020.23068\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1001%2Fjama.2020.23068\" aria-label=\"Article reference 19\" data-doi=\"10.1001\/jama.2020.23068\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33320224\" aria-label=\"PubMed reference 19\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7739139\" aria-label=\"PubMed Central reference 19\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 19\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Association%20between%20depressive%20symptoms%20and%20incident%20cardiovascular%20diseases&amp;journal=JAMA&amp;doi=10.1001%2Fjama.2020.23068&amp;volume=324&amp;issue=23&amp;pages=2396-2405&amp;publication_year=2020&amp;author=Harshfield%2CEL&amp;author=Pennells%2CL&amp;author=Schwartz%2CJE&amp;author=Willeit%2CP&amp;author=Kaptoge%2CS&amp;author=Bell%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR20\">Xia W, Jiang H, Di H, Feng J, Meng X, Xu M, et al. Association between self-reported depression and risk of all-cause mortality and cause-specific mortality. J Affect Disord. 2022;15(299):353\u20138.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.jad.2021.12.018\" data-track-item_id=\"10.1016\/j.jad.2021.12.018\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.jad.2021.12.018\" aria-label=\"Article reference 20\" data-doi=\"10.1016\/j.jad.2021.12.018\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 20\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Association%20between%20self-reported%20depression%20and%20risk%20of%20all-cause%20mortality%20and%20cause-specific%20mortality&amp;journal=J%20Affect%20Disord&amp;doi=10.1016%2Fj.jad.2021.12.018&amp;volume=15&amp;issue=299&amp;pages=353-358&amp;publication_year=2022&amp;author=Xia%2CW&amp;author=Jiang%2CH&amp;author=Di%2CH&amp;author=Feng%2CJ&amp;author=Meng%2CX&amp;author=Xu%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR21\">Dong JY, Zhang YH, Tong J, Qin LQ. Depression and risk of stroke: a meta-analysis of prospective studies. Stroke. 2012;43(1):32\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1161\/STROKEAHA.111.630871\" data-track-item_id=\"10.1161\/STROKEAHA.111.630871\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1161%2FSTROKEAHA.111.630871\" aria-label=\"Article reference 21\" data-doi=\"10.1161\/STROKEAHA.111.630871\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22020036\" aria-label=\"PubMed reference 21\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 21\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Depression%20and%20risk%20of%20stroke%3A%20a%20meta-analysis%20of%20prospective%20studies&amp;journal=Stroke&amp;doi=10.1161%2FSTROKEAHA.111.630871&amp;volume=43&amp;issue=1&amp;pages=32-37&amp;publication_year=2012&amp;author=Dong%2CJY&amp;author=Zhang%2CYH&amp;author=Tong%2CJ&amp;author=Qin%2CLQ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR22\">Ashraf F, Mustafa MS, Shafique MA, Haseeb A, Mussarat A, Noorani A, et al. Association between depression and stroke risk in adults: a systematic review and meta-analysis. Front Neurol. 2024;15: 1331300.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3389\/fneur.2024.1331300\" data-track-item_id=\"10.3389\/fneur.2024.1331300\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3389%2Ffneur.2024.1331300\" aria-label=\"Article reference 22\" data-doi=\"10.3389\/fneur.2024.1331300\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38725648\" aria-label=\"PubMed reference 22\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11079212\" aria-label=\"PubMed Central reference 22\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 22\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Association%20between%20depression%20and%20stroke%20risk%20in%20adults%3A%20a%20systematic%20review%20and%20meta-analysis&amp;journal=Front%20Neurol&amp;doi=10.3389%2Ffneur.2024.1331300&amp;volume=15&amp;publication_year=2024&amp;author=Ashraf%2CF&amp;author=Mustafa%2CMS&amp;author=Shafique%2CMA&amp;author=Haseeb%2CA&amp;author=Mussarat%2CA&amp;author=Noorani%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR23\">Kiecolt-Glaser JK, Derry HM, Fagundes CP. Inflammation: depression fans the flames and feasts on the heat. Am J Psychiatry. 2015;172(11):1075\u201391.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1176\/appi.ajp.2015.15020152\" data-track-item_id=\"10.1176\/appi.ajp.2015.15020152\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1176%2Fappi.ajp.2015.15020152\" aria-label=\"Article reference 23\" data-doi=\"10.1176\/appi.ajp.2015.15020152\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26357876\" aria-label=\"PubMed reference 23\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6511978\" aria-label=\"PubMed Central reference 23\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 23\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inflammation%3A%20depression%20fans%20the%20flames%20and%20feasts%20on%20the%20heat&amp;journal=Am%20J%20Psychiatry&amp;doi=10.1176%2Fappi.ajp.2015.15020152&amp;volume=172&amp;issue=11&amp;pages=1075-1091&amp;publication_year=2015&amp;author=Kiecolt-Glaser%2CJK&amp;author=Derry%2CHM&amp;author=Fagundes%2CCP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR24\">Beurel E, Toups M, Nemeroff CB. The bidirectional relationship of depression and inflammation: double trouble. Neuron. 2020;107(2):234\u201356.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.neuron.2020.06.002\" data-track-item_id=\"10.1016\/j.neuron.2020.06.002\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.neuron.2020.06.002\" aria-label=\"Article reference 24\" data-doi=\"10.1016\/j.neuron.2020.06.002\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXht1Wmtr%2FI\" aria-label=\"CAS reference 24\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32553197\" aria-label=\"PubMed reference 24\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7381373\" aria-label=\"PubMed Central reference 24\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 24\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20bidirectional%20relationship%20of%20depression%20and%20inflammation%3A%20double%20trouble&amp;journal=Neuron&amp;doi=10.1016%2Fj.neuron.2020.06.002&amp;volume=107&amp;issue=2&amp;pages=234-256&amp;publication_year=2020&amp;author=Beurel%2CE&amp;author=Toups%2CM&amp;author=Nemeroff%2CCB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR25\">Lamers F, Jonkers CC, Bosma H, Penninx BW, Knottnerus JA, van Eijk JT. Summed score of the patient health questionnaire-9 was a reliable and valid method for depression screening in chronically ill elderly patients. J Clin Epidemiol. 2008;61(7):679\u201387.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.jclinepi.2007.07.018\" data-track-item_id=\"10.1016\/j.jclinepi.2007.07.018\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.jclinepi.2007.07.018\" aria-label=\"Article reference 25\" data-doi=\"10.1016\/j.jclinepi.2007.07.018\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=18538262\" aria-label=\"PubMed reference 25\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 25\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Summed%20score%20of%20the%20patient%20health%20questionnaire-9%20was%20a%20reliable%20and%20valid%20method%20for%20depression%20screening%20in%20chronically%20ill%20elderly%20patients&amp;journal=J%20Clin%20Epidemiol&amp;doi=10.1016%2Fj.jclinepi.2007.07.018&amp;volume=61&amp;issue=7&amp;pages=679-687&amp;publication_year=2008&amp;author=Lamers%2CF&amp;author=Jonkers%2CCC&amp;author=Bosma%2CH&amp;author=Penninx%2CBW&amp;author=Knottnerus%2CJA&amp;author=Eijk%2CJT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR26\">Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606\u201313.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1046\/j.1525-1497.2001.016009606.x\" data-track-item_id=\"10.1046\/j.1525-1497.2001.016009606.x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1046%2Fj.1525-1497.2001.016009606.x\" aria-label=\"Article reference 26\" data-doi=\"10.1046\/j.1525-1497.2001.016009606.x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:STN:280:DC%2BD3MrhtVWnsQ%3D%3D\" aria-label=\"CAS reference 26\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=11556941\" aria-label=\"PubMed reference 26\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1495268\" aria-label=\"PubMed Central reference 26\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 26\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20PHQ-9%3A%20validity%20of%20a%20brief%20depression%20severity%20measure&amp;journal=J%20Gen%20Intern%20Med&amp;doi=10.1046%2Fj.1525-1497.2001.016009606.x&amp;volume=16&amp;issue=9&amp;pages=606-613&amp;publication_year=2001&amp;author=Kroenke%2CK&amp;author=Spitzer%2CRL&amp;author=Williams%2CJB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR27\">Anrather J, Iadecola C. Inflammation and stroke: an overview. Neurotherapeutics. 2016;13(4):661\u201370.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1007\/s13311-016-0483-x\" data-track-item_id=\"10.1007\/s13311-016-0483-x\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s13311-016-0483-x\" aria-label=\"Article reference 27\" data-doi=\"10.1007\/s13311-016-0483-x\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28Xhs1OgsLzK\" aria-label=\"CAS reference 27\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27730544\" aria-label=\"PubMed reference 27\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5081118\" aria-label=\"PubMed Central reference 27\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 27\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inflammation%20and%20stroke%3A%20an%20overview&amp;journal=Neurotherapeutics&amp;doi=10.1007%2Fs13311-016-0483-x&amp;volume=13&amp;issue=4&amp;pages=661-670&amp;publication_year=2016&amp;author=Anrather%2CJ&amp;author=Iadecola%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR28\">Nidorf SM, Fiolet ATL, Mosterd A, Eikelboom JW, Schut A, Opstal TSJ, et al. Colchicine in patients with chronic coronary disease. N Engl J Med. 2020;383(19):1838\u201347.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1056\/NEJMoa2021372\" data-track-item_id=\"10.1056\/NEJMoa2021372\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1056%2FNEJMoa2021372\" aria-label=\"Article reference 28\" data-doi=\"10.1056\/NEJMoa2021372\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXit1yltL7N\" aria-label=\"CAS reference 28\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32865380\" aria-label=\"PubMed reference 28\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 28\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Colchicine%20in%20patients%20with%20chronic%20coronary%20disease&amp;journal=N%20Engl%20J%20Med&amp;doi=10.1056%2FNEJMoa2021372&amp;volume=383&amp;issue=19&amp;pages=1838-1847&amp;publication_year=2020&amp;author=Nidorf%2CSM&amp;author=Fiolet%2CATL&amp;author=Mosterd%2CA&amp;author=Eikelboom%2CJW&amp;author=Schut%2CA&amp;author=Opstal%2CTSJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR29\">Stark K, Massberg S. Interplay between inflammation and thrombosis in cardiovascular pathology. Nat Rev Cardiol. 2021;18(9):666\u201382.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41569-021-00552-1\" data-track-item_id=\"10.1038\/s41569-021-00552-1\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41569-021-00552-1\" aria-label=\"Article reference 29\" data-doi=\"10.1038\/s41569-021-00552-1\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33958774\" aria-label=\"PubMed reference 29\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8100938\" aria-label=\"PubMed Central reference 29\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 29\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Interplay%20between%20inflammation%20and%20thrombosis%20in%20cardiovascular%20pathology&amp;journal=Nat%20Rev%20Cardiol&amp;doi=10.1038%2Fs41569-021-00552-1&amp;volume=18&amp;issue=9&amp;pages=666-682&amp;publication_year=2021&amp;author=Stark%2CK&amp;author=Massberg%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR30\">Hermann DM, Kleinschnitz C, Gunzer M. Implications of polymorphonuclear neutrophils for ischemic stroke and intracerebral hemorrhage: predictive value, pathophysiological consequences and utility as therapeutic target. J Neuroimmunol. 2018;15(321):138\u201343.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.jneuroim.2018.04.015\" data-track-item_id=\"10.1016\/j.jneuroim.2018.04.015\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.jneuroim.2018.04.015\" aria-label=\"Article reference 30\" data-doi=\"10.1016\/j.jneuroim.2018.04.015\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 30\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Implications%20of%20polymorphonuclear%20neutrophils%20for%20ischemic%20stroke%20and%20intracerebral%20hemorrhage%3A%20predictive%20value%2C%20pathophysiological%20consequences%20and%20utility%20as%20therapeutic%20target&amp;journal=J%20Neuroimmunol&amp;doi=10.1016%2Fj.jneuroim.2018.04.015&amp;volume=15&amp;issue=321&amp;pages=138-143&amp;publication_year=2018&amp;author=Hermann%2CDM&amp;author=Kleinschnitz%2CC&amp;author=Gunzer%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR31\">Mohamud Yusuf A, Hagemann N, Ludewig P, Gunzer M, Hermann DM. Roles of polymorphonuclear neutrophils in ischemic brain injury and post-ischemic brain remodeling. Front Immunol. 2021;12: 825572.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3389\/fimmu.2021.825572\" data-track-item_id=\"10.3389\/fimmu.2021.825572\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3389%2Ffimmu.2021.825572\" aria-label=\"Article reference 31\" data-doi=\"10.3389\/fimmu.2021.825572\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35087539\" aria-label=\"PubMed reference 31\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 31\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Roles%20of%20polymorphonuclear%20neutrophils%20in%20ischemic%20brain%20injury%20and%20post-ischemic%20brain%20remodeling&amp;journal=Front%20Immunol&amp;doi=10.3389%2Ffimmu.2021.825572&amp;volume=12&amp;publication_year=2021&amp;author=Mohamud%20Yusuf%2CA&amp;author=Hagemann%2CN&amp;author=Ludewig%2CP&amp;author=Gunzer%2CM&amp;author=Hermann%2CDM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR32\">Chu HX, Kim HA, Lee S, Moore JP, Chan CT, Vinh A, et al. Immune cell infiltration in malignant middle cerebral artery infarction: comparison with transient cerebral ischemia. J Cereb Blood Flow Metab. 2014;34(3):450\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/jcbfm.2013.217\" data-track-item_id=\"10.1038\/jcbfm.2013.217\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fjcbfm.2013.217\" aria-label=\"Article reference 32\" data-doi=\"10.1038\/jcbfm.2013.217\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXhvFCru7jM\" aria-label=\"CAS reference 32\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24326388\" aria-label=\"PubMed reference 32\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 32\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Immune%20cell%20infiltration%20in%20malignant%20middle%20cerebral%20artery%20infarction%3A%20comparison%20with%20transient%20cerebral%20ischemia&amp;journal=J%20Cereb%20Blood%20Flow%20Metab&amp;doi=10.1038%2Fjcbfm.2013.217&amp;volume=34&amp;issue=3&amp;pages=450-459&amp;publication_year=2014&amp;author=Chu%2CHX&amp;author=Kim%2CHA&amp;author=Lee%2CS&amp;author=Moore%2CJP&amp;author=Chan%2CCT&amp;author=Vinh%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR33\">Qiu YM, Zhang CL, Chen AQ, Wang HL, Zhou YF, Li YN, et al. Immune cells in the BBB disruption after acute ischemic stroke: targets for immune therapy? Front Immunol. 2021;12: 678744.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3389\/fimmu.2021.678744\" data-track-item_id=\"10.3389\/fimmu.2021.678744\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3389%2Ffimmu.2021.678744\" aria-label=\"Article reference 33\" data-doi=\"10.3389\/fimmu.2021.678744\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXhvFeks7jL\" aria-label=\"CAS reference 33\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34248961\" aria-label=\"PubMed reference 33\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8260997\" aria-label=\"PubMed Central reference 33\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 33\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Immune%20cells%20in%20the%20BBB%20disruption%20after%20acute%20ischemic%20stroke%3A%20targets%20for%20immune%20therapy%3F&amp;journal=Front%20Immunol&amp;doi=10.3389%2Ffimmu.2021.678744&amp;volume=12&amp;publication_year=2021&amp;author=Qiu%2CYM&amp;author=Zhang%2CCL&amp;author=Chen%2CAQ&amp;author=Wang%2CHL&amp;author=Zhou%2CYF&amp;author=Li%2CYN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR34\">Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol. 2011;11(8):519\u201331.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nri3024\" data-track-item_id=\"10.1038\/nri3024\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnri3024\" aria-label=\"Article reference 34\" data-doi=\"10.1038\/nri3024\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXptlaku7g%3D\" aria-label=\"CAS reference 34\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21785456\" aria-label=\"PubMed reference 34\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 34\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neutrophils%20in%20the%20activation%20and%20regulation%20of%20innate%20and%20adaptive%20immunity&amp;journal=Nat%20Rev%20Immunol&amp;doi=10.1038%2Fnri3024&amp;volume=11&amp;issue=8&amp;pages=519-531&amp;publication_year=2011&amp;author=Mantovani%2CA&amp;author=Cassatella%2CMA&amp;author=Costantini%2CC&amp;author=Jaillon%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR35\">Mayer-Barber KD, Barber DL. Innate and Adaptive Cellular Immune Responses to Mycobacterium tuberculosis Infection. Cold Spring Harb Perspect Med. 2015;5(12):a018424.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1101\/cshperspect.a018424\" data-track-item_id=\"10.1101\/cshperspect.a018424\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1101%2Fcshperspect.a018424\" aria-label=\"Article reference 35\" data-doi=\"10.1101\/cshperspect.a018424\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26187873\" aria-label=\"PubMed reference 35\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4665043\" aria-label=\"PubMed Central reference 35\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 35\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Innate%20and%20Adaptive%20Cellular%20Immune%20Responses%20to%20Mycobacterium%20tuberculosis%20Infection&amp;journal=Cold%20Spring%20Harb%20Perspect%20Med&amp;doi=10.1101%2Fcshperspect.a018424&amp;volume=5&amp;issue=12&amp;publication_year=2015&amp;author=Mayer-Barber%2CKD&amp;author=Barber%2CDL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR36\">Buonacera A, Stancanelli B, Colaci M, Malatino L. Neutrophil to lymphocyte ratio: an emerging marker of the relationships between the immune system and diseases. Int J Mol Sci. 2022;23(7):3636.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/ijms23073636\" data-track-item_id=\"10.3390\/ijms23073636\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fijms23073636\" aria-label=\"Article reference 36\" data-doi=\"10.3390\/ijms23073636\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhtVajsL7I\" aria-label=\"CAS reference 36\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35408994\" aria-label=\"PubMed reference 36\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8998851\" aria-label=\"PubMed Central reference 36\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 36\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neutrophil%20to%20lymphocyte%20ratio%3A%20an%20emerging%20marker%20of%20the%20relationships%20between%20the%20immune%20system%20and%20diseases&amp;journal=Int%20J%20Mol%20Sci&amp;doi=10.3390%2Fijms23073636&amp;volume=23&amp;issue=7&amp;publication_year=2022&amp;author=Buonacera%2CA&amp;author=Stancanelli%2CB&amp;author=Colaci%2CM&amp;author=Malatino%2CL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR37\">Giede-Jeppe A, Madzar D, Sembill JA, Sprugel MI, Atay S, Hoelter P, et al. Increased neutrophil-to-Lymphocyte ratio is associated with unfavorable functional outcome in acute ischemic stroke. Neurocrit Care. 2020;33(1):97\u2013104.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1007\/s12028-019-00859-5\" data-track-item_id=\"10.1007\/s12028-019-00859-5\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s12028-019-00859-5\" aria-label=\"Article reference 37\" data-doi=\"10.1007\/s12028-019-00859-5\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXhvFOqsrzP\" aria-label=\"CAS reference 37\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31617117\" aria-label=\"PubMed reference 37\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 37\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Increased%20neutrophil-to-Lymphocyte%20ratio%20is%20associated%20with%20unfavorable%20functional%20outcome%20in%20acute%20ischemic%20stroke&amp;journal=Neurocrit%20Care&amp;doi=10.1007%2Fs12028-019-00859-5&amp;volume=33&amp;issue=1&amp;pages=97-104&amp;publication_year=2020&amp;author=Giede-Jeppe%2CA&amp;author=Madzar%2CD&amp;author=Sembill%2CJA&amp;author=Sprugel%2CMI&amp;author=Atay%2CS&amp;author=Hoelter%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR38\">Xue J, Huang W, Chen X, Li Q, Cai Z, Yu T, et al. Neutrophil-to-lymphocyte ratio is a prognostic marker in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2017;26(3):650\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.jstrokecerebrovasdis.2016.11.010\" data-track-item_id=\"10.1016\/j.jstrokecerebrovasdis.2016.11.010\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.jstrokecerebrovasdis.2016.11.010\" aria-label=\"Article reference 38\" data-doi=\"10.1016\/j.jstrokecerebrovasdis.2016.11.010\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=27955949\" aria-label=\"PubMed reference 38\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 38\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neutrophil-to-lymphocyte%20ratio%20is%20a%20prognostic%20marker%20in%20acute%20ischemic%20stroke&amp;journal=J%20Stroke%20Cerebrovasc%20Dis&amp;doi=10.1016%2Fj.jstrokecerebrovasdis.2016.11.010&amp;volume=26&amp;issue=3&amp;pages=650-657&amp;publication_year=2017&amp;author=Xue%2CJ&amp;author=Huang%2CW&amp;author=Chen%2CX&amp;author=Li%2CQ&amp;author=Cai%2CZ&amp;author=Yu%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR39\">Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther. 2013;11(1):55\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1586\/erc.12.159\" data-track-item_id=\"10.1586\/erc.12.159\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1586%2Ferc.12.159\" aria-label=\"Article reference 39\" data-doi=\"10.1586\/erc.12.159\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38XhvVynsb3M\" aria-label=\"CAS reference 39\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=23259445\" aria-label=\"PubMed reference 39\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 39\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neutrophil%20to%20lymphocyte%20ratio%20and%20cardiovascular%20diseases%3A%20a%20review&amp;journal=Expert%20Rev%20Cardiovasc%20Ther&amp;doi=10.1586%2Ferc.12.159&amp;volume=11&amp;issue=1&amp;pages=55-59&amp;publication_year=2013&amp;author=Bhat%2CT&amp;author=Teli%2CS&amp;author=Rijal%2CJ&amp;author=Bhat%2CH&amp;author=Raza%2CM&amp;author=Khoueiry%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR40\">Afari ME, Bhat T. Neutrophil to lymphocyte ratio (NLR) and cardiovascular diseases: an update. Expert Rev Cardiovasc Ther. 2016;14(5):573\u20137.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1586\/14779072.2016.1154788\" data-track-item_id=\"10.1586\/14779072.2016.1154788\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1586%2F14779072.2016.1154788\" aria-label=\"Article reference 40\" data-doi=\"10.1586\/14779072.2016.1154788\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XjvVyksrw%3D\" aria-label=\"CAS reference 40\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=26878164\" aria-label=\"PubMed reference 40\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 40\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neutrophil%20to%20lymphocyte%20ratio%20%28NLR%29%20and%20cardiovascular%20diseases%3A%20an%20update&amp;journal=Expert%20Rev%20Cardiovasc%20Ther&amp;doi=10.1586%2F14779072.2016.1154788&amp;volume=14&amp;issue=5&amp;pages=573-577&amp;publication_year=2016&amp;author=Afari%2CME&amp;author=Bhat%2CT\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR41\">Adamstein NH, MacFadyen JG, Rose LM, Glynn RJ, Dey AK, Libby P, et al. The neutrophil-lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials. Eur Heart J. 2021;42(9):896\u2013903.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1093\/eurheartj\/ehaa1034\" data-track-item_id=\"10.1093\/eurheartj\/ehaa1034\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1093%2Feurheartj%2Fehaa1034\" aria-label=\"Article reference 41\" data-doi=\"10.1093\/eurheartj\/ehaa1034\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXitValsL3F\" aria-label=\"CAS reference 41\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=33417682\" aria-label=\"PubMed reference 41\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7936519\" aria-label=\"PubMed Central reference 41\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 41\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20neutrophil-lymphocyte%20ratio%20and%20incident%20atherosclerotic%20events%3A%20analyses%20from%20five%20contemporary%20randomized%20trials&amp;journal=Eur%20Heart%20J&amp;doi=10.1093%2Feurheartj%2Fehaa1034&amp;volume=42&amp;issue=9&amp;pages=896-903&amp;publication_year=2021&amp;author=Adamstein%2CNH&amp;author=MacFadyen%2CJG&amp;author=Rose%2CLM&amp;author=Glynn%2CRJ&amp;author=Dey%2CAK&amp;author=Libby%2CP\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR42\">Huguet E, Maccallini G, Pardini P, Hidalgo M, Obregon S, Botto F, et al. Reference values for neutrophil to lymphocyte ratio (NLR), a biomarker of cardiovascular risk, according to age and sex in a Latin American population. Curr Probl Cardiol. 2021;46(3):100422.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.cpcardiol.2019.04.002\" data-track-item_id=\"10.1016\/j.cpcardiol.2019.04.002\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.cpcardiol.2019.04.002\" aria-label=\"Article reference 42\" data-doi=\"10.1016\/j.cpcardiol.2019.04.002\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=31103219\" aria-label=\"PubMed reference 42\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 42\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Reference%20values%20for%20neutrophil%20to%20lymphocyte%20ratio%20%28NLR%29%2C%20a%20biomarker%20of%20cardiovascular%20risk%2C%20according%20to%20age%20and%20sex%20in%20a%20Latin%20American%20population&amp;journal=Curr%20Probl%20Cardiol&amp;doi=10.1016%2Fj.cpcardiol.2019.04.002&amp;volume=46&amp;issue=3&amp;publication_year=2021&amp;author=Huguet%2CE&amp;author=Maccallini%2CG&amp;author=Pardini%2CP&amp;author=Hidalgo%2CM&amp;author=Obregon%2CS&amp;author=Botto%2CF\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR43\">Yu Y, Qian L, Cui J. Value of neutrophil-to-lymphocyte ratio for predicting lung cancer prognosis: a meta-analysis of 7219 patients. Mol Clin Oncol. 2017;7(3):498\u2013506.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3892\/mco.2017.1342\" data-track-item_id=\"10.3892\/mco.2017.1342\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3892%2Fmco.2017.1342\" aria-label=\"Article reference 43\" data-doi=\"10.3892\/mco.2017.1342\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC1MXjvFaqtbw%3D\" aria-label=\"CAS reference 43\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28811903\" aria-label=\"PubMed reference 43\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5547766\" aria-label=\"PubMed Central reference 43\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 43\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Value%20of%20neutrophil-to-lymphocyte%20ratio%20for%20predicting%20lung%20cancer%20prognosis%3A%20a%20meta-analysis%20of%207219%20patients&amp;journal=Mol%20Clin%20Oncol&amp;doi=10.3892%2Fmco.2017.1342&amp;volume=7&amp;issue=3&amp;pages=498-506&amp;publication_year=2017&amp;author=Yu%2CY&amp;author=Qian%2CL&amp;author=Cui%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR44\">Haram A, Boland MR, Kelly ME, Bolger JC, Waldron RM, Kerin MJ. The prognostic value of neutrophil-to-lymphocyte ratio in colorectal cancer: a systematic review. J Surg Oncol. 2017;115(4):470\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1002\/jso.24523\" data-track-item_id=\"10.1002\/jso.24523\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1002%2Fjso.24523\" aria-label=\"Article reference 44\" data-doi=\"10.1002\/jso.24523\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXmsVSluro%3D\" aria-label=\"CAS reference 44\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28105646\" aria-label=\"PubMed reference 44\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 44\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20prognostic%20value%20of%20neutrophil-to-lymphocyte%20ratio%20in%20colorectal%20cancer%3A%20a%20systematic%20review&amp;journal=J%20Surg%20Oncol&amp;doi=10.1002%2Fjso.24523&amp;volume=115&amp;issue=4&amp;pages=470-479&amp;publication_year=2017&amp;author=Haram%2CA&amp;author=Boland%2CMR&amp;author=Kelly%2CME&amp;author=Bolger%2CJC&amp;author=Waldron%2CRM&amp;author=Kerin%2CMJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR45\">Zhu Q, Zhang Q, Chen C, Liu M, He Y, Zhao Y, et al. C-reactive protein, neutrophil-to-lymphocyte ratio, and long-term mortality in Chinese centenarians. JAMA Netw Open. 2023;6(10): e2340307.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1001\/jamanetworkopen.2023.40307\" data-track-item_id=\"10.1001\/jamanetworkopen.2023.40307\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1001%2Fjamanetworkopen.2023.40307\" aria-label=\"Article reference 45\" data-doi=\"10.1001\/jamanetworkopen.2023.40307\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37902758\" aria-label=\"PubMed reference 45\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10616724\" aria-label=\"PubMed Central reference 45\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 45\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=C-reactive%20protein%2C%20neutrophil-to-lymphocyte%20ratio%2C%20and%20long-term%20mortality%20in%20Chinese%20centenarians&amp;journal=JAMA%20Netw%20Open&amp;doi=10.1001%2Fjamanetworkopen.2023.40307&amp;volume=6&amp;issue=10&amp;publication_year=2023&amp;author=Zhu%2CQ&amp;author=Zhang%2CQ&amp;author=Chen%2CC&amp;author=Liu%2CM&amp;author=He%2CY&amp;author=Zhao%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR46\">Bushnell C. Depression and the risk of stroke in women: an identification and treatment paradox. Stroke. 2011;42(10):2718\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1161\/STROKEAHA.111.626895\" data-track-item_id=\"10.1161\/STROKEAHA.111.626895\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1161%2FSTROKEAHA.111.626895\" aria-label=\"Article reference 46\" data-doi=\"10.1161\/STROKEAHA.111.626895\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21921282\" aria-label=\"PubMed reference 46\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 46\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Depression%20and%20the%20risk%20of%20stroke%20in%20women%3A%20an%20identification%20and%20treatment%20paradox&amp;journal=Stroke&amp;doi=10.1161%2FSTROKEAHA.111.626895&amp;volume=42&amp;issue=10&amp;pages=2718-2719&amp;publication_year=2011&amp;author=Bushnell%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR47\">Pan A, Okereke OI, Sun Q, Logroscino G, Manson JE, Willett WC, et al. Depression and incident stroke in women. Stroke. 2011;42(10):2770\u20135.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1161\/STROKEAHA.111.617043\" data-track-item_id=\"10.1161\/STROKEAHA.111.617043\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1161%2FSTROKEAHA.111.617043\" aria-label=\"Article reference 47\" data-doi=\"10.1161\/STROKEAHA.111.617043\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21836097\" aria-label=\"PubMed reference 47\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3183155\" aria-label=\"PubMed Central reference 47\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 47\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Depression%20and%20incident%20stroke%20in%20women&amp;journal=Stroke&amp;doi=10.1161%2FSTROKEAHA.111.617043&amp;volume=42&amp;issue=10&amp;pages=2770-2775&amp;publication_year=2011&amp;author=Pan%2CA&amp;author=Okereke%2COI&amp;author=Sun%2CQ&amp;author=Logroscino%2CG&amp;author=Manson%2CJE&amp;author=Willett%2CWC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR48\">Murphy RP, Reddin C, Rosengren A, Judge C, Hankey GJ, Ferguson J, et al. Depressive symptoms and risk of acute stroke: INTERSTROKE case-control study. Neurology. 2023;100(17):e1787\u201398.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1212\/WNL.0000000000207093\" data-track-item_id=\"10.1212\/WNL.0000000000207093\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1212%2FWNL.0000000000207093\" aria-label=\"Article reference 48\" data-doi=\"10.1212\/WNL.0000000000207093\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=36889922\" aria-label=\"PubMed reference 48\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10136021\" aria-label=\"PubMed Central reference 48\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 48\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Depressive%20symptoms%20and%20risk%20of%20acute%20stroke%3A%20INTERSTROKE%20case-control%20study&amp;journal=Neurology&amp;doi=10.1212%2FWNL.0000000000207093&amp;volume=100&amp;issue=17&amp;pages=e1787-e1798&amp;publication_year=2023&amp;author=Murphy%2CRP&amp;author=Reddin%2CC&amp;author=Rosengren%2CA&amp;author=Judge%2CC&amp;author=Hankey%2CGJ&amp;author=Ferguson%2CJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR49\">Nilsson FM, Kessing LV. Increased risk of developing stroke for patients with major affective disorder\u2013a registry study. Eur Arch Psychiatry Clin Neurosci. 2004;254(6):387\u201391.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1007\/s00406-004-0519-9\" data-track-item_id=\"10.1007\/s00406-004-0519-9\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s00406-004-0519-9\" aria-label=\"Article reference 49\" data-doi=\"10.1007\/s00406-004-0519-9\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15538602\" aria-label=\"PubMed reference 49\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 49\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Increased%20risk%20of%20developing%20stroke%20for%20patients%20with%20major%20affective%20disorder%E2%80%93a%20registry%20study&amp;journal=Eur%20Arch%20Psychiatry%20Clin%20Neurosci&amp;doi=10.1007%2Fs00406-004-0519-9&amp;volume=254&amp;issue=6&amp;pages=387-391&amp;publication_year=2004&amp;author=Nilsson%2CFM&amp;author=Kessing%2CLV\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR50\">Malach M, Imperato PJ. Depression and acute myocardial infarction. Prev Cardiol. 2004;7(2):83\u201390.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=15133376\" aria-label=\"PubMed reference 50\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 50\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Depression%20and%20acute%20myocardial%20infarction&amp;journal=Prev%20Cardiol&amp;volume=7&amp;issue=2&amp;pages=83-90&amp;publication_year=2004&amp;author=Malach%2CM&amp;author=Imperato%2CPJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR51\">Meng R, Yu C, Liu N, He M, Lv J, Guo Y, et al. Association of depression with all-cause and cardiovascular disease mortality among adults in China. JAMA Netw Open. 2020;3(2): e1921043.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1001\/jamanetworkopen.2019.21043\" data-track-item_id=\"10.1001\/jamanetworkopen.2019.21043\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1001%2Fjamanetworkopen.2019.21043\" aria-label=\"Article reference 51\" data-doi=\"10.1001\/jamanetworkopen.2019.21043\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32049295\" aria-label=\"PubMed reference 51\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7212017\" aria-label=\"PubMed Central reference 51\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 51\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Association%20of%20depression%20with%20all-cause%20and%20cardiovascular%20disease%20mortality%20among%20adults%20in%20China&amp;journal=JAMA%20Netw%20Open&amp;doi=10.1001%2Fjamanetworkopen.2019.21043&amp;volume=3&amp;issue=2&amp;publication_year=2020&amp;author=Meng%2CR&amp;author=Yu%2CC&amp;author=Liu%2CN&amp;author=He%2CM&amp;author=Lv%2CJ&amp;author=Guo%2CY\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR52\">Pan A, Sun Q, Okereke OI, Rexrode KM, Hu FB. Depression and risk of stroke morbidity and mortality: a meta-analysis and systematic review. JAMA. 2011;306(11):1241\u20139.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1001\/jama.2011.1282\" data-track-item_id=\"10.1001\/jama.2011.1282\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1001%2Fjama.2011.1282\" aria-label=\"Article reference 52\" data-doi=\"10.1001\/jama.2011.1282\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3MXht1ahtLvE\" aria-label=\"CAS reference 52\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=21934057\" aria-label=\"PubMed reference 52\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3242806\" aria-label=\"PubMed Central reference 52\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 52\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Depression%20and%20risk%20of%20stroke%20morbidity%20and%20mortality%3A%20a%20meta-analysis%20and%20systematic%20review&amp;journal=JAMA&amp;doi=10.1001%2Fjama.2011.1282&amp;volume=306&amp;issue=11&amp;pages=1241-1249&amp;publication_year=2011&amp;author=Pan%2CA&amp;author=Sun%2CQ&amp;author=Okereke%2COI&amp;author=Rexrode%2CKM&amp;author=Hu%2CFB\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR53\">Lawes S, Demakakos P, Steptoe A, Lewis G, Carvalho LA. Combined influence of depressive symptoms and systemic inflammation on all-cause and cardiovascular mortality: evidence for differential effects by gender in the English longitudinal study of ageing. Psychol Med. 2019;49(9):1521\u201331.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1017\/S003329171800209X\" data-track-item_id=\"10.1017\/S003329171800209X\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1017%2FS003329171800209X\" aria-label=\"Article reference 53\" data-doi=\"10.1017\/S003329171800209X\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=30220259\" aria-label=\"PubMed reference 53\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 53\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Combined%20influence%20of%20depressive%20symptoms%20and%20systemic%20inflammation%20on%20all-cause%20and%20cardiovascular%20mortality%3A%20evidence%20for%20differential%20effects%20by%20gender%20in%20the%20English%20longitudinal%20study%20of%20ageing&amp;journal=Psychol%20Med&amp;doi=10.1017%2FS003329171800209X&amp;volume=49&amp;issue=9&amp;pages=1521-1531&amp;publication_year=2019&amp;author=Lawes%2CS&amp;author=Demakakos%2CP&amp;author=Steptoe%2CA&amp;author=Lewis%2CG&amp;author=Carvalho%2CLA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR54\">Knezevic E, Nenic K, Milanovic V, Knezevic NN. The role of cortisol in chronic stress, neurodegenerative diseases, and psychological disorders. Cells. 2023. <a href=\"https:\/\/doi.org\/10.3390\/cells12232726\" data-track=\"click_references\" data-track-action=\"external reference\" data-track-value=\"external reference\" data-track-label=\"10.3390\/cells12232726\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/doi.org\/10.3390\/cells12232726<\/a>.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/cells12232726\" data-track-item_id=\"10.3390\/cells12232726\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fcells12232726\" aria-label=\"Article reference 54\" data-doi=\"10.3390\/cells12232726\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38067154\" aria-label=\"PubMed reference 54\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10706127\" aria-label=\"PubMed Central reference 54\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 54\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=The%20role%20of%20cortisol%20in%20chronic%20stress%2C%20neurodegenerative%20diseases%2C%20and%20psychological%20disorders&amp;journal=Cells&amp;doi=10.3390%2Fcells12232726&amp;publication_year=2023&amp;author=Knezevic%2CE&amp;author=Nenic%2CK&amp;author=Milanovic%2CV&amp;author=Knezevic%2CNN\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR55\">Peverelli E, Catalano R, Giardino E, Treppiedi D, Morelli V, Ronchi CL, et al. Cofilin is a cAMP effector in mediating actin cytoskeleton reorganization and steroidogenesis in mouse and human adrenocortical tumor cells. Cancer Lett. 2017;10(406):54\u201363.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.canlet.2017.07.025\" data-track-item_id=\"10.1016\/j.canlet.2017.07.025\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.canlet.2017.07.025\" aria-label=\"Article reference 55\" data-doi=\"10.1016\/j.canlet.2017.07.025\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 55\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Cofilin%20is%20a%20cAMP%20effector%20in%20mediating%20actin%20cytoskeleton%20reorganization%20and%20steroidogenesis%20in%20mouse%20and%20human%20adrenocortical%20tumor%20cells&amp;journal=Cancer%20Lett&amp;doi=10.1016%2Fj.canlet.2017.07.025&amp;volume=10&amp;issue=406&amp;pages=54-63&amp;publication_year=2017&amp;author=Peverelli%2CE&amp;author=Catalano%2CR&amp;author=Giardino%2CE&amp;author=Treppiedi%2CD&amp;author=Morelli%2CV&amp;author=Ronchi%2CCL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR56\">Hassamal S. Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories. Front Psychiatry. 2023;14:1130989.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3389\/fpsyt.2023.1130989\" data-track-item_id=\"10.3389\/fpsyt.2023.1130989\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3389%2Ffpsyt.2023.1130989\" aria-label=\"Article reference 56\" data-doi=\"10.3389\/fpsyt.2023.1130989\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=37252156\" aria-label=\"PubMed reference 56\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10213648\" aria-label=\"PubMed Central reference 56\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 56\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Chronic%20stress%2C%20neuroinflammation%2C%20and%20depression%3A%20an%20overview%20of%20pathophysiological%20mechanisms%20and%20emerging%20anti-inflammatories&amp;journal=Front%20Psychiatry&amp;doi=10.3389%2Ffpsyt.2023.1130989&amp;volume=14&amp;publication_year=2023&amp;author=Hassamal%2CS\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR57\">Zhong S, Li L, Shen X, Li Q, Xu W, Wang X, et al. An update on lipid oxidation and inflammation in cardiovascular diseases. Free Radic Biol Med. 2019;20(144):266\u201378.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.freeradbiomed.2019.03.036\" data-track-item_id=\"10.1016\/j.freeradbiomed.2019.03.036\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.freeradbiomed.2019.03.036\" aria-label=\"Article reference 57\" data-doi=\"10.1016\/j.freeradbiomed.2019.03.036\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 57\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=An%20update%20on%20lipid%20oxidation%20and%20inflammation%20in%20cardiovascular%20diseases&amp;journal=Free%20Radic%20Biol%20Med&amp;doi=10.1016%2Fj.freeradbiomed.2019.03.036&amp;volume=20&amp;issue=144&amp;pages=266-278&amp;publication_year=2019&amp;author=Zhong%2CS&amp;author=Li%2CL&amp;author=Shen%2CX&amp;author=Li%2CQ&amp;author=Xu%2CW&amp;author=Wang%2CX\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR58\">Braidy N, Grant R. Kynurenine pathway metabolism and neuroinflammatory disease. Neural Regen Res. 2017;12(1):39\u201342.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.4103\/1673-5374.198971\" data-track-item_id=\"10.4103\/1673-5374.198971\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.4103%2F1673-5374.198971\" aria-label=\"Article reference 58\" data-doi=\"10.4103\/1673-5374.198971\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3MXit1GitLc%3D\" aria-label=\"CAS reference 58\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=28250737\" aria-label=\"PubMed reference 58\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5319230\" aria-label=\"PubMed Central reference 58\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 58\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Kynurenine%20pathway%20metabolism%20and%20neuroinflammatory%20disease&amp;journal=Neural%20Regen%20Res&amp;doi=10.4103%2F1673-5374.198971&amp;volume=12&amp;issue=1&amp;pages=39-42&amp;publication_year=2017&amp;author=Braidy%2CN&amp;author=Grant%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR59\">Kondo T, Okada Y, Shizuya S, Yamaguchi N, Hatakeyama S, Maruyama K. Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders. Eur J Cell Biol. 2024;103(2): 151418.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.ejcb.2024.151418\" data-track-item_id=\"10.1016\/j.ejcb.2024.151418\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.ejcb.2024.151418\" aria-label=\"Article reference 59\" data-doi=\"10.1016\/j.ejcb.2024.151418\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXhtVGntbnJ\" aria-label=\"CAS reference 59\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=38729083\" aria-label=\"PubMed reference 59\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 59\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Neuroimmune%20modulation%20by%20tryptophan%20derivatives%20in%20neurological%20and%20inflammatory%20disorders&amp;journal=Eur%20J%20Cell%20Biol&amp;doi=10.1016%2Fj.ejcb.2024.151418&amp;volume=103&amp;issue=2&amp;publication_year=2024&amp;author=Kondo%2CT&amp;author=Okada%2CY&amp;author=Shizuya%2CS&amp;author=Yamaguchi%2CN&amp;author=Hatakeyama%2CS&amp;author=Maruyama%2CK\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR60\">Cheiran Pereira G, Piton E, Moreira Dos Santos B, Ramanzini LG, Muniz Camargo LF, Menezes da Silva R, et al. Microglia and HPA axis in depression: an overview of participation and relationship. World J Biol Psychiatry. 2022;23(3):165\u201382.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1080\/15622975.2021.1939154\" data-track-item_id=\"10.1080\/15622975.2021.1939154\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1080%2F15622975.2021.1939154\" aria-label=\"Article reference 60\" data-doi=\"10.1080\/15622975.2021.1939154\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XislyjsbnI\" aria-label=\"CAS reference 60\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=34100334\" aria-label=\"PubMed reference 60\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 60\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Microglia%20and%20HPA%20axis%20in%20depression%3A%20an%20overview%20of%20participation%20and%20relationship&amp;journal=World%20J%20Biol%20Psychiatry&amp;doi=10.1080%2F15622975.2021.1939154&amp;volume=23&amp;issue=3&amp;pages=165-182&amp;publication_year=2022&amp;author=Cheiran%20Pereira%2CG&amp;author=Piton%2CE&amp;author=Moreira%20Dos%20Santos%2CB&amp;author=Ramanzini%2CLG&amp;author=Muniz%20Camargo%2CLF&amp;author=Menezes%20da%20Silva%2CR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR61\">Choudhary A, Kumar A, Jindal M, Rhuthuparna M, Munshi A. Microrna signatures in neuroplasticity, neuroinflammation and neurotransmission in association with depression. J Physiol Biochem. 2025;81(1):85\u201397.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"noopener nofollow\" data-track-label=\"10.1007\/s13105-024-01065-4\" data-track-item_id=\"10.1007\/s13105-024-01065-4\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/link.springer.com\/doi\/10.1007\/s13105-024-01065-4\" aria-label=\"Article reference 61\" data-doi=\"10.1007\/s13105-024-01065-4\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB2cXivVKgt73O\" aria-label=\"CAS reference 61\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=39695016\" aria-label=\"PubMed reference 61\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 61\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Microrna%20signatures%20in%20neuroplasticity%2C%20neuroinflammation%20and%20neurotransmission%20in%20association%20with%20depression&amp;journal=J%20Physiol%20Biochem&amp;doi=10.1007%2Fs13105-024-01065-4&amp;volume=81&amp;issue=1&amp;pages=85-97&amp;publication_year=2025&amp;author=Choudhary%2CA&amp;author=Kumar%2CA&amp;author=Jindal%2CM&amp;author=Rhuthuparna%2CM&amp;author=Munshi%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR62\">Kong P, Cui ZY, Huang XF, Zhang DD, Guo RJ, Han M. Inflammation and atherosclerosis: signaling pathways and therapeutic intervention. Signal Transduct Target Ther. 2022;7(1):131.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41392-022-00955-7\" data-track-item_id=\"10.1038\/s41392-022-00955-7\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41392-022-00955-7\" aria-label=\"Article reference 62\" data-doi=\"10.1038\/s41392-022-00955-7\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhsVOls7rF\" aria-label=\"CAS reference 62\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35459215\" aria-label=\"PubMed reference 62\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9033871\" aria-label=\"PubMed Central reference 62\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 62\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inflammation%20and%20atherosclerosis%3A%20signaling%20pathways%20and%20therapeutic%20intervention&amp;journal=Signal%20Transduct%20Target%20Ther&amp;doi=10.1038%2Fs41392-022-00955-7&amp;volume=7&amp;issue=1&amp;publication_year=2022&amp;author=Kong%2CP&amp;author=Cui%2CZY&amp;author=Huang%2CXF&amp;author=Zhang%2CDD&amp;author=Guo%2CRJ&amp;author=Han%2CM\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR63\">Drakopoulou M, Toutouzas K, Michelongona A, Tousoulis D, Stefanadis C. Vulnerable plaque and inflammation: potential clinical strategies. Curr Pharm Des. 2011;17(37):4190\u2013209.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.2174\/138161211798764816\" data-track-item_id=\"10.2174\/138161211798764816\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.2174%2F138161211798764816\" aria-label=\"Article reference 63\" data-doi=\"10.2174\/138161211798764816\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC38XovFWqug%3D%3D\" aria-label=\"CAS reference 63\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=22204378\" aria-label=\"PubMed reference 63\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 63\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Vulnerable%20plaque%20and%20inflammation%3A%20potential%20clinical%20strategies&amp;journal=Curr%20Pharm%20Des&amp;doi=10.2174%2F138161211798764816&amp;volume=17&amp;issue=37&amp;pages=4190-4209&amp;publication_year=2011&amp;author=Drakopoulou%2CM&amp;author=Toutouzas%2CK&amp;author=Michelongona%2CA&amp;author=Tousoulis%2CD&amp;author=Stefanadis%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR64\">Tuttolomondo A, Daidone M, Pinto A. Endothelial dysfunction and inflammation in ischemic stroke pathogenesis. Curr Pharm Des. 2020;26(34):4209\u201319.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.2174\/1381612826666200417154126\" data-track-item_id=\"10.2174\/1381612826666200417154126\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.2174%2F1381612826666200417154126\" aria-label=\"Article reference 64\" data-doi=\"10.2174\/1381612826666200417154126\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXisFGlsLnL\" aria-label=\"CAS reference 64\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32303167\" aria-label=\"PubMed reference 64\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 64\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Endothelial%20dysfunction%20and%20inflammation%20in%20ischemic%20stroke%20pathogenesis&amp;journal=Curr%20Pharm%20Des&amp;doi=10.2174%2F1381612826666200417154126&amp;volume=26&amp;issue=34&amp;pages=4209-4219&amp;publication_year=2020&amp;author=Tuttolomondo%2CA&amp;author=Daidone%2CM&amp;author=Pinto%2CA\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR65\">Slavich GM, Irwin MR. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull. 2014;140(3):774\u2013815.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1037\/a0035302\" data-track-item_id=\"10.1037\/a0035302\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1037%2Fa0035302\" aria-label=\"Article reference 65\" data-doi=\"10.1037\/a0035302\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=24417575\" aria-label=\"PubMed reference 65\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4006295\" aria-label=\"PubMed Central reference 65\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 65\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=From%20stress%20to%20inflammation%20and%20major%20depressive%20disorder%3A%20a%20social%20signal%20transduction%20theory%20of%20depression&amp;journal=Psychol%20Bull&amp;doi=10.1037%2Fa0035302&amp;volume=140&amp;issue=3&amp;pages=774-815&amp;publication_year=2014&amp;author=Slavich%2CGM&amp;author=Irwin%2CMR\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR66\">Walther A, Mackens-Kiani A, Eder J, Herbig M, Herold C, Kirschbaum C, et al. Depressive disorders are associated with increased peripheral blood cell deformability: a cross-sectional case-control study (Mood-Morph). Transl Psychiatry. 2022;12(1):150.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41398-022-01911-3\" data-track-item_id=\"10.1038\/s41398-022-01911-3\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41398-022-01911-3\" aria-label=\"Article reference 66\" data-doi=\"10.1038\/s41398-022-01911-3\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB38XhsFykt7vP\" aria-label=\"CAS reference 66\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=35396373\" aria-label=\"PubMed reference 66\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8990596\" aria-label=\"PubMed Central reference 66\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 66\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Depressive%20disorders%20are%20associated%20with%20increased%20peripheral%20blood%20cell%20deformability%3A%20a%20cross-sectional%20case-control%20study%20%28Mood-Morph%29&amp;journal=Transl%20Psychiatry&amp;doi=10.1038%2Fs41398-022-01911-3&amp;volume=12&amp;issue=1&amp;publication_year=2022&amp;author=Walther%2CA&amp;author=Mackens-Kiani%2CA&amp;author=Eder%2CJ&amp;author=Herbig%2CM&amp;author=Herold%2CC&amp;author=Kirschbaum%2CC\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR67\">Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 2009;65(9):732\u201341.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.biopsych.2008.11.029\" data-track-item_id=\"10.1016\/j.biopsych.2008.11.029\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.biopsych.2008.11.029\" aria-label=\"Article reference 67\" data-doi=\"10.1016\/j.biopsych.2008.11.029\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BD1MXktV2qsb0%3D\" aria-label=\"CAS reference 67\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=19150053\" aria-label=\"PubMed reference 67\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2680424\" aria-label=\"PubMed Central reference 67\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 67\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Inflammation%20and%20its%20discontents%3A%20the%20role%20of%20cytokines%20in%20the%20pathophysiology%20of%20major%20depression&amp;journal=Biol%20Psychiatry&amp;doi=10.1016%2Fj.biopsych.2008.11.029&amp;volume=65&amp;issue=9&amp;pages=732-741&amp;publication_year=2009&amp;author=Miller%2CAH&amp;author=Maletic%2CV&amp;author=Raison%2CCL\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR68\">Conti P, Lauritano D, Caraffa A, Gallenga CE, Kritas SK, Ronconi G, et al. Microglia and mast cells generate proinflammatory cytokines in the brain and worsen inflammatory state: suppressor effect of IL-37. Eur J Pharmacol. 2020;15(875): 173035.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.ejphar.2020.173035\" data-track-item_id=\"10.1016\/j.ejphar.2020.173035\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.ejphar.2020.173035\" aria-label=\"Article reference 68\" data-doi=\"10.1016\/j.ejphar.2020.173035\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 68\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Microglia%20and%20mast%20cells%20generate%20proinflammatory%20cytokines%20in%20the%20brain%20and%20worsen%20inflammatory%20state%3A%20suppressor%20effect%20of%20IL-37&amp;journal=Eur%20J%20Pharmacol&amp;doi=10.1016%2Fj.ejphar.2020.173035&amp;volume=15&amp;issue=875&amp;publication_year=2020&amp;author=Conti%2CP&amp;author=Lauritano%2CD&amp;author=Caraffa%2CA&amp;author=Gallenga%2CCE&amp;author=Kritas%2CSK&amp;author=Ronconi%2CG\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<p class=\"c-article-references__text\" id=\"ref-CR69\">Ting EY, Yang AC, Tsai SJ. Role of interleukin-6 in depressive disorder. Int J Mol Sci. 2020;21(6):2194.<\/p>\n<p class=\"c-article-references__links u-hide-print\"><a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"10.3390\/ijms21062194\" data-track-item_id=\"10.3390\/ijms21062194\" data-track-value=\"article reference\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.3390%2Fijms21062194\" aria-label=\"Article reference 69\" data-doi=\"10.3390\/ijms21062194\" target=\"_blank\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"cas reference\" data-track-action=\"cas reference\" href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/cas-redirect\/1:CAS:528:DC%2BB3cXhvVejsb7O\" aria-label=\"CAS reference 69\" target=\"_blank\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed reference\" data-track-action=\"pubmed reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Abstract&amp;list_uids=32235786\" aria-label=\"PubMed reference 69\" target=\"_blank\">PubMed<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-item_id=\"link\" data-track-value=\"pubmed central reference\" data-track-action=\"pubmed central reference\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7139933\" aria-label=\"PubMed Central reference 69\" target=\"_blank\">PubMed Central<\/a>\u00a0<br \/>\n    <a data-track=\"click_references\" data-track-action=\"google scholar reference\" data-track-value=\"google scholar reference\" data-track-label=\"link\" data-track-item_id=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 69\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&amp;title=Role%20of%20interleukin-6%20in%20depressive%20disorder&amp;journal=Int%20J%20Mol%20Sci&amp;doi=10.3390%2Fijms21062194&amp;volume=21&amp;issue=6&amp;publication_year=2020&amp;author=Ting%2CEY&amp;author=Yang%2CAC&amp;author=Tsai%2CSJ\" target=\"_blank\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n","protected":false},"excerpt":{"rendered":"Diseases GBD, Injuries C. Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a&hellip;\n","protected":false},"author":2,"featured_media":142152,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[49,48,64196,84,76287,10506,76286,2986,26445,12078],"class_list":{"0":"post-142151","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-ca","9":"tag-canada","10":"tag-depressive-symptoms","11":"tag-health","12":"tag-major-adverse-cardiovascular-events","13":"tag-mortality","14":"tag-neutrophil-to-lymphocyte-ratio","15":"tag-psychiatry","16":"tag-psychotherapy","17":"tag-stroke"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/142151","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=142151"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/142151\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/142152"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=142151"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=142151"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=142151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}