{"id":153383,"date":"2025-09-18T20:46:18","date_gmt":"2025-09-18T20:46:18","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/153383\/"},"modified":"2025-09-18T20:46:18","modified_gmt":"2025-09-18T20:46:18","slug":"three-deadliest-risk-factors-of-a-common-liver-disease-identified-in-new-study","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/153383\/","title":{"rendered":"Three deadliest risk factors of a common liver disease identified in new study"},"content":{"rendered":"

LOS ANGELES \u2014 More than a third of the world\u2019s population is affected by metabolic dysfunction-associated steatotic liver disease, or MASLD, the most common chronic liver disease in the world.\u00a0\u00a0<\/p>\n

MASLD occurs when fat builds up in the liver and is associated with one or more of five conditions: obesity, Type 2 diabetes, high blood pressure, high blood sugar and low HDL cholesterol, known as \u201cgood\u201d cholesterol. These conditions are characterized as cardiometabolic risk factors because they affect the heart or metabolism.\u00a0\u00a0<\/p>\n

MASLD can lead to serious illness, such as advanced liver, heart and kidney disease, but little research has been done to examine if certain cardiometabolic risk factors for those with MASLD are more associated with death than others.\u00a0\u00a0<\/p>\n

The deadliest cardiometabolic risk factors\u00a0\u00a0<\/p>\n

Now, a new study<\/a> from Keck Medicine of USC<\/a> published in Clinical Gastroenterology and Hepatology reveals that three of the cardiometabolic risk factors carry the greatest risk of death for those with MASLD: high blood pressure, pre-diabetes or Type 2 diabetes, and low HDL, which raise the risk of death by 40%, 25% and 15%, respectively.\u00a0\u00a0<\/p>\n

These results were independent of how many or which combination of cardiometabolic risk factors patients had, and held steady despite individuals\u2019 gender, sex, race or ethnicity.\u00a0\u00a0<\/p>\n

\u201cMASLD is a complicated disease, and this study sheds new light on where doctors may want to focus their efforts when treating patients,\u201d said Norah A. Terrault, MD<\/a>, a hepatologist with Keck Medicine and a senior author of the study. \u201cKnowing which aspects of MASLD might lead to poorer outcomes can help us offer patients the best possible care.\u201d\u00a0\u00a0<\/p>\n

Researchers were especially surprised to discover that high blood pressure was associated with a higher chance of death than diabetes, said Matthew Dukewich, MD, PharmD, MS, a USC transplant hepatology fellow and lead author of the study. \u201cUntil now, it was commonly thought that diabetes was the most pressing health problem for MASLD patients, which is a key insight.\u201d\u00a0<\/p>\n

The study also found that obesity, the most common cardiometabolic risk factor of MASLD,\u00a0 can substantially raise the risk of mortality depending on a patient\u2019s body mass index (BMI), which is a formula used to estimate body fat percentage based on an individual\u2019s height and weight. The higher a patient\u2019s BMI, the higher the association with death.\u00a0<\/p>\n

Additionally, the study adds to the growing body of research that patients with more cardiometabolic risk factors have poorer outcomes. The study found that the risk of death in MASLD patients increased by 15% for each additional cardiometabolic risk factor present.\u00a0<\/p>\n

How the study was conducted\u00a0\u00a0<\/p>\n

Researchers used data from the National Health and Nutrition Examination Survey (NHANES), which collected health information about children and adults in the United States from 1988-2018, the most current year for which data was available for their study. Out of 134,515 participants 20 years or older, some 21,000 patients qualified as having MASLD.\u00a0\u00a0<\/p>\n

The study authors tracked all-cause mortality rates by individual cardiometabolic risk factors to reach their conclusions.\u00a0\u00a0<\/p>\n

Looking ahead, the study authors hope to conduct further studies examining patients\u2019 genetic background, dietary habits and alcohol use in relation to MASLD outcomes to provide more comprehensive risk profiles. \u201cThe more we can understand about the drivers of the disease, the more we can identify those most in need of interventions and prioritize our resources for enhanced outcomes,\u201d said Terrault.\u00a0\u00a0<\/p>\n

Liyun Yuan, MD<\/a>, a transplant hepatologist with Keck Medicine, is also a study author.\u00a0<\/p>\n

‘;<\/p>\n","protected":false},"excerpt":{"rendered":"LOS ANGELES \u2014 More than a third of the world\u2019s population is affected by metabolic dysfunction-associated steatotic liver…\n","protected":false},"author":2,"featured_media":153384,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[49,48,84,80976,6926,24693,994],"class_list":["post-153383","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-ca","tag-canada","tag-health","tag-keck-medicine-of-usc","tag-liver-disease","tag-releases","tag-research"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/153383","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=153383"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/153383\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/153384"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=153383"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=153383"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=153383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}