{"id":188667,"date":"2025-10-04T03:05:23","date_gmt":"2025-10-04T03:05:23","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/188667\/"},"modified":"2025-10-04T03:05:23","modified_gmt":"2025-10-04T03:05:23","slug":"one-size-fits-nearly-all-fix-for-v2r-mutations","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/188667\/","title":{"rendered":"One-size-fits-(nearly)-all fix for V2R mutations"},"content":{"rendered":"<p>Genetic\/congenital<\/p>\n<p>Genetic mutations are the primary cause of most rare diseases. Although each condition affects a small fraction of the population, the global impact is significant, with an estimated 300 million individuals affected worldwide. A large proportion of pathogenic missense variants \u2013 estimated at 40%-60% \u2013 cause rare diseases by impairing protein stability. This underscores protein restoration as a promising therapeutic strategy. <\/p>\n<p><a class=\"topic\" href=\"https:\/\/www.bioworld.com\/topics\/520-bioworld-science\" rel=\"nofollow noopener\" target=\"_blank\">BioWorld Science<\/a> <a class=\"topic\" href=\"https:\/\/www.bioworld.com\/topics\/548-genetic-congenital\" rel=\"nofollow noopener\" target=\"_blank\">Genetic\/congenital<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"Genetic\/congenital Genetic mutations are the primary cause of most rare diseases. Although each condition affects a small fraction&hellip;\n","protected":false},"author":2,"featured_media":188668,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[56166,49,48,94472,56167,316,94475,2992,66,94474,94473],"class_list":{"0":"post-188667","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetics","8":"tag-bioworld-science","9":"tag-ca","10":"tag-canada","11":"tag-centre-for-genomic-regulation","12":"tag-genetic-congenital","13":"tag-genetics","14":"tag-nephrogenic-diabetes-insipidus","15":"tag-rare-disease","16":"tag-science","17":"tag-tolvaptan","18":"tag-vasopressin-v2-receptor"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/188667","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=188667"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/188667\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/188668"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=188667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=188667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=188667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}