{"id":229945,"date":"2025-10-21T18:35:07","date_gmt":"2025-10-21T18:35:07","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/229945\/"},"modified":"2025-10-21T18:35:07","modified_gmt":"2025-10-21T18:35:07","slug":"hcs-3dx-platform-enables-large-scale-high-precision-screening-of-cellular-models","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/229945\/","title":{"rendered":"HCS-3DX platform enables large-scale, high-precision screening of cellular models"},"content":{"rendered":"<p>The HCS-3DX platform performs automated analysis of three-dimensional cell cultures, known as spheroids. Using AI-based image processing and sample selection, the system enables large-scale, high-precision screening of cellular models within a fraction of the usual time.<\/p>\n<p>&#8220;Our goal was to create a unified platform that integrates the strengths of existing technologies and can be easily implemented in research and industry&#8221; said \u00c1kos Di\u00f3sdi, first author of the study.<\/p>\n<p>According to Dr. P\u00e9ter Horv\u00e1th, director of the Institute of Biochemistry at the HUN-REN Biological Research Centre, Szeged and senior author of the paper:<\/p>\n<p>&#8220;One of the main bottlenecks in personalized medicine has been the limited throughput of cell-based assays. The HCS-3DX system removes this limitation, allowing for fast, large-scale, and highly accurate analysis.&#8221;<\/p>\n<p>The technology is already being tested on clinical samples through a collaboration with the Heidelberg Children&#8217;s Hospital, where miniature tumor models derived from pediatric brain cancer patients are used to identify the most effective therapeutic options.<\/p>\n<p>Source:<\/p>\n<p><a href=\"https:\/\/www.brc.hu\/en\" rel=\"noopener nofollow\" target=\"_blank\">HUN-REN Szegedi Biol\u00f3giai Kutat\u00f3k\u00f6zpont<\/a><\/p>\n<p>Journal reference:<\/p>\n<p>Diosdi, A., et al. (2025). HCS-3DX, a next-generation AI-driven automated 3D-oid high-content screening system.\u00a0Nature Communications. <a href=\"https:\/\/doi.org\/10.1038\/s41467-025-63955-5\" rel=\"noopener nofollow\" target=\"_blank\">doi.org\/10.1038\/s41467-025-63955-5<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"The HCS-3DX platform performs automated analysis of three-dimensional cell cultures, known as spheroids. Using AI-based image processing and&hellip;\n","protected":false},"author":2,"featured_media":69745,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[49,48,11242,84,11246,109580,1058,73393,994],"class_list":{"0":"post-229945","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-ca","9":"tag-canada","10":"tag-cell","11":"tag-health","12":"tag-imaging","13":"tag-mechanobiology","14":"tag-medicine","15":"tag-organoids","16":"tag-research"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/229945","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=229945"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/229945\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/69745"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=229945"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=229945"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=229945"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}