The San Francisco 49ers continue to battle key injuries, but they just keep winning as they enter Week 8 with a 5-2 record. Brock Purdy’s toe injury has kept him out of all but two games this year, and Mac Jones is 4-1 as a starter and will be under center again on Sunday. The Houston Texans are just 2-4 on the year and have struggled offensively. That unit will be tested even more on Sunday as star receiver Nico Collins is dealing with a concussion, taking away quarterback C.J. Stroud’s top option in the passing game.<\/p>\n
Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 1.5-point favorites, according to the latest 49ers vs. Texans odds. The over\/under for total points scored is 42. Before you make any Texans vs. 49ers picks, make sure to check out what the SportsLine Projection Model has to say.\u00a0<\/p>\n
Click here<\/a> to bet 49ers vs. Texans at DraftKings Sportsbook, where new users\u00a0get $300 in bonus bets if your first bet wins and three free months of NBA League Pass<\/a>:<\/p>\n Where to bet on 49ers vs. TexansWhere to watch 49ers vs. Texans on Sunday<\/p>\n When:\u00a0Sunday, Oct. 26 49ers vs. Texans betting preview<\/p>\n Odds:\u00a0Texans -1.5, over\/under 42<\/p>\n The Texans can’t afford to lose too many more games if they want to repeat as AFC South champs, especially with the Indianapolis Colts off to a stellar 6-1 start. The 49ers, meanwhile, are one of three 5-2 teams in the NFC West.\u00a0<\/p>\n The 49ers are 4-3 against the spread this year, and their games have gone Over the total in four of seven contests. The Texans, meanwhile, are 2-4 against the spread and only two of their six games have gone Over, both because their defense has been very good and their offense has struggled early in 2025.<\/p>\n Click here<\/a>\u00a0to bet 49ers vs. Texans at FanDuel Sportsbook, where new users get $300 in bonus bets if their first bet of at least $5 wins<\/a>:<\/p>\n Model’s 49ers vs. Texans score prediction, picks<\/p>\n Even with Jones set to start again in place of Purdy, the 49ers have to be feeling good about this matchup against a Texans team that has only beat the lowly Tennessee Titans and a Lamar Jackson-less Baltimore Ravens team. San Francisco has been able to cover in the majority of its games this year, and the SportsLine Projection Model has the 49ers covering +1.5 in the majority of simulations, good for a ‘B’ grade.<\/p>\n 49ers vs. Texans score prediction: Texans 21, 49ers 20<\/p>\n Want more Week 8 NFL picks?<\/p>\n
Time:\u00a01 p.m. ET
TV:\u00a0FOX
Stream:\u00a0Fubo<\/a>
Follow along:\u00a0CBS Sports App<\/a><\/p>\n