powerful new tools to study the earliest stages of cancer development<\/a>.<\/p>\nNew Approach Methodologies utilise human-relevant technologies, such as in vitro tests, organoids, organs-on-a-chip, and computational modelling, to replace, reduce, or refine animal testing.<\/p>\n
New approach methodologies open up new clues about cancer<\/p>\n
These lab-grown models replicate the environment inside the human body and could unlock clues about how cancer begins.<\/p>\n
At the helm of a new chip-based system that more accurately mimics the human bone-tumour environment, the team is using advanced bioengineering to create more realistic in-vitro models.<\/p>\n
This represents a significant step forward in the Food and Drug Administration\u2019s shift toward human-cell-based systems, marking a key milestone in its transition away from animal testing.<\/p>\n
Luiz Bertassoni, senior author of the research, explained: \u201cEarly cancer detection is one of the most important survival factors.<\/p>\n
\u201cThese new technologies give us a window into how cancer forms and progresses, which opens the door to understanding early cancer, paving the way for earlier diagnosis and even predicting cancer initiation.\u201d<\/p>\n
Scientists don\u2019t fully know how healthy tissue becomes cancerous<\/p>\n
Despite years of cancer research, scientists know relatively little about what happens in the body during the early stages of cancer.<\/p>\n
A major reason is the lack of access to early-stage tumour samples, especially in organs that are hard to reach. Patients usually come to the clinic after symptoms have already appeared, which is often too late.<\/p>\n
Without samples of early cancer, it\u2019s difficult to understand the changes that occur as healthy tissue becomes cancerous.<\/p>\n
Tissue engineering improves early cancer detection rates<\/p>\n
Tissue engineering is helping close that gap. Recent technologies developed over the past decade, including many designed at the OHSU Knight Cancer Institute, have enabled scientists to replicate the complexity of cancer in the lab.<\/p>\n
These models, which have recently been prioritised as so-called New Approach Methodologies for medical research, enable researchers to recreate and manipulate the early tumour environment precisely, allowing them to test how specific cellular, genetic, or environmental factors influence cancer development.<\/p>\n
This approach also supports the discovery of new biomarkers \u2013 biological red flags that could help clinicians detect cancer earlier and more accurately.<\/p>\n
\u201cThis is a really exciting time in cancer research,\u201d Bertassoni said. \u201cThere is momentum in bringing together cancer biology, engineering and clinical treatment. There are so many avenues that didn\u2019t exist before.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"Researchers have identified how new advances in 3D bioprinting, organoids, and organ-on-a-chip technology can help detect cancer earlier.…\n","protected":false},"author":2,"featured_media":260815,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[49,48,7714,84,36348],"class_list":{"0":"post-260814","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-ca","9":"tag-canada","10":"tag-cancer","11":"tag-health","12":"tag-health-technology"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/260814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=260814"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/260814\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/260815"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=260814"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=260814"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=260814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}