{"id":293120,"date":"2025-11-19T11:12:06","date_gmt":"2025-11-19T11:12:06","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/293120\/"},"modified":"2025-11-19T11:12:06","modified_gmt":"2025-11-19T11:12:06","slug":"new-drug-could-be-a-breakthrough-in-treatment-for-killer-tb-trial-suggests-global-health","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/293120\/","title":{"rendered":"New drug could be a breakthrough in treatment for killer TB, trial suggests | Global health"},"content":{"rendered":"<p class=\"dcr-130mj7b\">A new treatment for tuberculosis could boost cure rates and shorten the time needed to treat the disease by months, trial results suggest.<\/p>\n<p class=\"dcr-130mj7b\">Globally, an estimated 10.7 million people fell ill with TB last year and 1.23 million died from it.<\/p>\n<p class=\"dcr-130mj7b\">In its <a href=\"https:\/\/iris.who.int\/server\/api\/core\/bitstreams\/e97dd6f4-b567-4396-8680-717bac6869a9\/content\" data-link-name=\"in body link\" rel=\"nofollow noopener\" target=\"_blank\">annual report on tuberculosis<\/a>, launched last week, the World Health Organization said it remained a \u201cmajor global public-health problem\u201d and the leading infectious cause of death.<\/p>\n<p class=\"dcr-130mj7b\">Progress is being threatened by aid cuts and already falling short of targets towards a UN goal of ending TB as a public-health threat this decade, the WHO said.<\/p>\n<p class=\"dcr-130mj7b\">Sorfequiline, a new antibiotic, showed stronger action against the deadly bacteria than existing treatments, with a comparable safety profile, researchers from the TB Alliance told the Union Conference on Lung <a href=\"https:\/\/www.theguardian.com\/society\/health\" data-link-name=\"in body link\" data-component=\"auto-linked-tag\" rel=\"nofollow noopener\" target=\"_blank\">Health<\/a> in Copenhagen on Wednesday.<\/p>\n<p class=\"dcr-130mj7b\">The trial involved 309 people across 22 sites in <a href=\"https:\/\/www.theguardian.com\/world\/southafrica\" data-link-name=\"in body link\" data-component=\"auto-linked-tag\" rel=\"nofollow noopener\" target=\"_blank\">South Africa<\/a>, the Philippines, Georgia, Tanzania and Uganda, with different dose regimens.<\/p>\n<p class=\"dcr-130mj7b\">All participants had \u201cdrug-sensitive\u201d tuberculosis, meaning a standard cocktail of drugs can safely treat them but researchers believe TB infections that are resistant to standard treatment could also be helped.<\/p>\n<p class=\"dcr-130mj7b\">The trial suggested a sorfequiline-based regimen could be used for anyone testing positive, said Dr Maria Beumont, vice-president of TB Alliance.<\/p>\n<p class=\"dcr-130mj7b\">She said: \u201cI can just put you on a treatment while I\u2019m waiting to understand exactly what your situation is. I don\u2019t need to wait to get information back and classify you as drug sensitive, this or that regimen. There is no need to go through all of that.\u201d<\/p>\n<p class=\"dcr-130mj7b\">Access to swift diagnostic tests for TB is patchy and it can take days or weeks in some places for doctors to get laboratories to identify the TB type a patient has before they can be helped.<\/p>\n<p class=\"dcr-130mj7b\">Dr William Brumskine, clinical research site leader at the Aurum Institute in Rustenburg, South <a href=\"https:\/\/www.theguardian.com\/world\/africa\" data-link-name=\"in body link\" data-component=\"auto-linked-tag\" rel=\"nofollow noopener\" target=\"_blank\">Africa<\/a>, said he hoped overall care would be improved. \u201cThe hope of having a universal regimen that is shorter, that has less side-effects, is you will have less individuals coming in for clinic visits [and so] the health care providers will have more time to give individual care to patients,\u201d he said.<\/p>\n<p>Phase-2 trials of a sorfequiline-based regimen at the University of Cape Town Lung Institute. TB Alliance hopes to launch phase 3 in 2026. Photograph: Jonathan Torgovnik\/TB Alliance<\/p>\n<p class=\"dcr-130mj7b\">A decade ago, patients with drug-resistant tuberculosis faced a gruelling treatment regimen of 18 months or more, involving multiple injections and hospital stays, that only cured about 50% of people. The current gold-standard treatment, introduced in 2019, successfully treats 90% of people within six months. Researchers hope using sorfequiline could improve things further.<\/p>\n<p class=\"dcr-130mj7b\">Beaumont said excitement had built before the full trial results arrived. \u201cIt\u2019s incredible when you start getting these little anecdotes from the sites [such as]: \u2018This patient got cured so fast. I don\u2019t know what arm [of the trial] he was on, but wow, I\u2019ve never seen this before.\u2019\u201d<\/p>\n<p class=\"dcr-130mj7b\">TB Alliance said it hoped to launch a phase-3 clinical trial in 2026.<\/p>\n<p class=\"dcr-130mj7b\">Dr Kavindhran Velen, chief scientific officer at the International Union against <a href=\"https:\/\/www.theguardian.com\/society\/tuberculosis\" data-link-name=\"in body link\" data-component=\"auto-linked-tag\" rel=\"nofollow noopener\" target=\"_blank\">Tuberculosis<\/a> and Lung Disease, which organised the conference, said a swifter, more effective TB treatment could have clear benefits, increasing the proportion of patients completing treatment and reducing the time they are contagious.<\/p>\n<p class=\"dcr-130mj7b\">However, he said he worried that applying it universally to TB patients could have downsides, including disincentivising health systems\u2019 investment in wider innovations such as laboratories and testing.<\/p>\n<p class=\"dcr-130mj7b\">He said doctors would need to be sure any universal TB treatment was not akin to \u201ctaking a hammer to an ant [for patients who could be treated with gentler drugs]. We don\u2019t want to overexpose an individual to treatment that is not necessarily needed.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"A new treatment for tuberculosis could boost cure rates and shorten the time needed to treat the disease&hellip;\n","protected":false},"author":2,"featured_media":293121,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[49,48,84,392],"class_list":{"0":"post-293120","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-healthcare","8":"tag-ca","9":"tag-canada","10":"tag-health","11":"tag-healthcare"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/293120","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=293120"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/293120\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/293121"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=293120"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=293120"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=293120"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}