{"id":520345,"date":"2026-03-07T12:12:11","date_gmt":"2026-03-07T12:12:11","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/520345\/"},"modified":"2026-03-07T12:12:11","modified_gmt":"2026-03-07T12:12:11","slug":"peanut-allergy-severity-shaped-by-microbiota","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/520345\/","title":{"rendered":"Peanut Allergy Severity Shaped by Microbiota"},"content":{"rendered":"

NEW research on immunoglobulin E (IgE)-mediated anaphylaxis suggests that food allergy severity may depend not only on the immune system, but also on how\u00a0bacteria<\/a>\u00a0in saliva and the small intestine metabolise allergens.\u00a0<\/p>\n

In a series of mechanistic and clinical experiments, researchers found that specific oral and small intestinal microbes\u00a0were capable of degrading\u00a0peanut allergens before they triggered severe allergic reactions. The findings suggested that microbial metabolism directly influenced the intensity of IgE-mediated anaphylaxis, offering a potential new avenue for reducing risk in patients with peanut allergy.\u00a0<\/p>\n

Food-induced anaphylaxis is an acute, potentially life-threatening systemic reaction driven\u00a0largely by\u00a0IgE antibodies, which bind allergens and activate mast cells. Peanut allergy\u00a0remains\u00a0one of the most common and severe causes, with reactions ranging from urticaria to cardiovascular collapse. While the\u00a0human\u00a0microbiota has previously been linked to oral tolerance, its direct role in shaping IgE-mediated responses has been unclear.\u00a0<\/p>\n

Human\u00a0Microbiota Degrade Peanut Allergens\u00a0<\/p>\n

The investigators\u00a0demonstrated\u00a0that human saliva and jejunal samples harboured peanut-degrading bacteria capable of metabolising the immunodominant allergens Ara h 1 and Ara h 2. In vitro experiments showed that isolated\u00a0Rothia\u00a0and\u00a0Staphylococcus\u00a0species broke down these allergens into fragments with reduced IgE binding capacity and diminished mast cell activation.\u00a0<\/p>\n

In mouse models colonised with\u00a0Rothia, levels of intact Ara h 1 and Ara h 2 in both local intestinal tissue and systemic circulation were significantly lower following peanut challenge. These mice experienced attenuated anaphylaxis compared with controls,\u00a0indicating\u00a0that microbial allergen metabolism limited both allergen absorption and downstream immune activation.\u00a0<\/p>\n

Clinical Links Between Microbes and Anaphylaxis Risk\u00a0<\/p>\n

Importantly, the translational arm of the study analysed samples from patients with peanut allergy. Individuals with higher abundance of common peanut-degrading bacteria, including\u00a0Rothia,\u00a0exhibited\u00a0a higher threshold for allergic reactions during controlled exposure. This suggested that microbial composition may help explain variability in anaphylaxis severity among patients with similar IgE profiles.\u00a0<\/p>\n

The data collectively supports a model in which gut microbiota actively modulate IgE-mediated anaphylaxis by enzymatically transforming food allergens before systemic absorption.\u00a0<\/p>\n

These findings raised the possibility that microbiota-targeted therapies, such as probiotics or microbial enzyme supplementation, could complement existing strategies for peanut allergy management. Further clinical trials will be\u00a0required\u00a0to\u00a0determine\u00a0whether\u00a0modifying\u00a0allergen-degrading bacterial populations can meaningfully reduce the risk or severity of IgE-mediated anaphylaxis in clinical practice.\u00a0<\/p>\n

Reference\u00a0<\/p>\n

S\u00e1nchez-Mart\u00ednez E et al. Microbial metabolism of food allergens\u00a0determines\u00a0the severity of IgE-mediated anaphylaxis.\u00a0Cell Host Microbe.\u00a02026;\u00a0DOI:10.1016\/j.chom.2026.02.013.\u00a0<\/p>\n

Featured image:\u00a0Q STOCK\u00a0on Adobe Stock\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"NEW research on immunoglobulin E (IgE)-mediated anaphylaxis suggests that food allergy severity may depend not only on the…\n","protected":false},"author":2,"featured_media":520346,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[49,48,84],"class_list":{"0":"post-520345","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-ca","9":"tag-canada","10":"tag-health"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/520345","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=520345"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/520345\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/520346"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=520345"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=520345"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=520345"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}