{"id":526742,"date":"2026-03-10T12:10:07","date_gmt":"2026-03-10T12:10:07","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/526742\/"},"modified":"2026-03-10T12:10:07","modified_gmt":"2026-03-10T12:10:07","slug":"doctors-have-long-said-cartilage-cant-regenerate-theyre-now-rethinking-that","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/526742\/","title":{"rendered":"Doctors have long said cartilage can\u2019t regenerate. They&#8217;re now rethinking that."},"content":{"rendered":"<p class=\"EkqkG IGXmU nlgHS yuUao lqtkC TjIXL aGjvy \">Human tissue echoed those findings. Cartilage samples taken from knee replacement surgeries responded to the inhibitor in the lab by producing new, functional hyaline cartilage, the smooth, resilient tissue that allows joints to glide.<\/p>\n<p class=\"EkqkG IGXmU nlgHS yuUao lqtkC TjIXL aGjvy \">\u201cPeople with joint pain are desperate to find relief, and they have very limited options,\u201d\u00a0says Blau.\u00a0Bhutani adds, \u201cThis new inhibitor can address the root cause of pain by repairing the\u00a0damage to the cartilage.\u201d<\/p>\n<p>Stopping the inflammation that destroys joints<\/p>\n<p class=\"EkqkG IGXmU nlgHS yuUao lqtkC TjIXL aGjvy \">Aging can slowly erode cartilage, but inflammation can destroy it quickly. At the Mayo Clinic, <a class=\"zZygg UbGlr iFzkS qdXbA WCDhQ DbOXS tqUtK GpWVU iJYzE \" data-testid=\"prism-linkbase\" href=\"https:\/\/www.mayo.edu\/research\/faculty\/evans-christopher-h-ph-d\/bio-20086893\" target=\"_blank\" dir=\"ltr\" rel=\"nofollow noopener\">Christopher Evans<\/a>, a professor of orthopedic surgery and molecular medicine, is focused less on regrowing cartilage, but on tackling the inflammatory signals that drive the disease itself.<\/p>\n<p class=\"EkqkG IGXmU nlgHS yuUao lqtkC TjIXL aGjvy \">\u201cIf we can stop the cycle of inflammation, we can preserve the joint before it fails,\u201d says Evans.<\/p>\n<p class=\"EkqkG IGXmU nlgHS yuUao lqtkC TjIXL aGjvy \">Evans has spent decades studying interleukin\u20111, a protein that helps the body respond to injury. In healthy tissue, its role is brief. In osteoarthritis, it lingers, fueling inflammation and accelerating cartilage breakdown. Blocking it with injected drugs has proven difficult because proteins introduced into a joint are quickly washed away through blood vessels and the lymphatic system.<\/p>\n","protected":false},"excerpt":{"rendered":"Human tissue echoed those findings. Cartilage samples taken from knee replacement surgeries responded to the inhibitor in the&hellip;\n","protected":false},"author":2,"featured_media":526743,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[49,207157,48,207156,207158,207160,207161,207159,66],"class_list":{"0":"post-526742","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-science","8":"tag-ca","9":"tag-can-cartilage-regrow","10":"tag-canada","11":"tag-cartilage-regeneration","12":"tag-cartilage-scaffold","13":"tag-joint-cartilage-repair","14":"tag-knee-cartilage-damage","15":"tag-osteoarthritis-research","16":"tag-science"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/526742","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=526742"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/526742\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/526743"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=526742"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=526742"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=526742"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}