{"id":624952,"date":"2026-04-24T06:07:17","date_gmt":"2026-04-24T06:07:17","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/624952\/"},"modified":"2026-04-24T06:07:17","modified_gmt":"2026-04-24T06:07:17","slug":"new-targeted-therapy-shows-promise-against-aggressive-childhood-and-adult-cancers","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/624952\/","title":{"rendered":"New targeted therapy shows promise against aggressive childhood and adult cancers"},"content":{"rendered":"

UBC-led study finds new therapy can eliminate tumours and stop cancer spread in preclinical models<\/p>\n

\"Child<\/p>\n

Researchers at the UBC Faculty of Medicine have developed a new targeted cancer therapy that can precisely seek out and destroy tumour cells \u2014 showing strong results in preclinical studies that bring the breakthrough closer to human clinical trials.<\/p>\n

The therapy targets a protein called IL1RAP, which is found on the surface of certain cancer cells, but is largely absent from normal tissues. By linking a cancer-killing drug to an antibody that recognizes this protein, the team created an antibody-drug conjugate that delivers treatment directly to cancer cells while sparing healthy tissues.<\/p>\n

\"Dr.Dr. Poul Sorensen<\/p>\n

In multiple models of Ewing sarcoma \u2014 a rare and aggressive cancer affecting children and young adults \u2014 the treatment eliminated established tumours and dramatically reduced the spread of cancer. Similar effects were seen in other cancers, including lymphoma and tumours driven by specific genetic alterations (NTRK fusions).<\/p>\n

The findings were recently published in Cancer Discovery<\/a>.<\/p>\n

\u201cThis is exactly the kind of target we look for, something that\u2019s present on cancer cells but largely absent from normal tissues,\u201d said senior author Dr. Poul Sorensen<\/a>, professor of pathology and laboratory medicine at UBC\u2019s Faculty of Medicine and a distinguished scientist at BC Cancer. \u201cIt allows us to deliver treatment with a high degree of precision.\u201d<\/p>\n

The study was an international collaboration that included researchers at UBC and BC Cancer, as well as academic and industry partners in the United States, Europe and Asia.<\/p>\n

Crucially, the therapy demonstrated a strong safety profile in preclinical testing, supporting its readiness for clinical development \u2014 an important step toward human trials.<\/p>\n

\"\"The antibody drug (green) precisely targets tumour cells (blue). Source: Sorensen Lab<\/p>\n

\u201cThis isn\u2019t a distant possibility,\u201d said Dr. Sorensen, who also holds the Johal Endowed Chair in Childhood Cancer Research. \u201cThe data position this for clinical trials in the very near future, pending the next steps in development and regulatory approval.\u201d<\/p>\n

\"Dr.Dr. Haifeng Zhang<\/p>\n

The approach builds on earlier work<\/a> by Dr. Sorensen and his team, including first author Dr. Haifeng Zhang from the Sorensen laboratory, which identified IL1RAP as a key protein that helps cancer cells survive in the bloodstream and spread to other parts of the body. When cancer cells break away from a primary tumour, they must endure a hostile environment in the circulatory system before establishing new tumours elsewhere. IL1RAP appears to help them adapt and survive during this process.<\/p>\n

Metastatic disease, which occurs when cancer spreads throughout the body, is the single most powerful predictor of poor outcome for cancer patients of all ages and has been a difficult process for researchers to study or for clinicians to target.<\/p>\n

\u201cWe think of this protein almost like a protective shield,\u201d said Dr. Zhang, a scientist in the Sorensen Lab. \u201cIt helps cancer cells withstand the stresses of travelling through the body and forming metastases. What we\u2019ve done here is turn that shield into a target, using it to deliver a drug directly into those cells.\u201d<\/p>\n

The findings highlight a promising new strategy for targeting cancers driven by specific genetic alterations that expresses the IL1RAP protein, potentially opening the door to more precise, effective treatments for both pediatric and adult patients.<\/p>\n","protected":false},"excerpt":{"rendered":"UBC-led study finds new therapy can eliminate tumours and stop cancer spread in preclinical models Researchers at the…\n","protected":false},"author":2,"featured_media":624953,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[2667,49,48,7714,84,2668,44,994,6760],"class_list":{"0":"post-624952","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health","8":"tag-byline-date-only","9":"tag-ca","10":"tag-canada","11":"tag-cancer","12":"tag-health","13":"tag-homepage","14":"tag-news","15":"tag-research","16":"tag-updates"},"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/624952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=624952"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/624952\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/624953"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=624952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=624952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=624952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}