Donovan Mitchell and the Cleveland Cavaliers willed their way to tie their series after an impressive Game 4 win in Ohio. Now the series heads north, where Cade Cunningham and the Detroit Pistons, the No. 1 seed in the Eastern Conference Playoffs, get an opportunity to keep the homecourt advantage. The Cavs are unbeaten at home in the 2026 NBA playoffs, but winless on the road.\u00a0<\/p>\n
Tipoff from Little Caesars Arena is Wednesday at 8 p.m. ET. Detroit is a 4.5-point favorite in the latest Cavaliers vs. Pistons odds from FanDuel Sportsbook, while the over\/under for total points scored is 212.5. Before making any Pistons vs. picks,\u00a0check out the Cavaliers vs. Pistons predictions from the SportsLine Projection Model<\/a>.<\/p>\n The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in\u00a0betting<\/a>\u00a0profit for $100 players on its top-rated\u00a0NBA picks<\/a>\u00a0over the past eight-plus seasons. The model entered the second week of the second round of the 2026 NBA playoffs on a sizzling 26-9 roll (74%) on top-rated NBA spread picks this season. Anyone following its\u00a0NBA betting<\/a>\u00a0advice at\u00a0sportsbooks<\/a>\u00a0and on\u00a0betting apps<\/a>\u00a0could have seen huge returns.<\/p>\n Now, the model has simulated Cavaliers vs. Pistons<\/a> 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model’s picks<\/a>. Here are several NBA odds<\/a> and NBA betting lines for Pistons vs. Cavaliers:<\/p>\n Cavaliers vs. Pistons spread:\u00a0 \u00a0\u00a0<\/p>\n Pistons -4.5 at FanDuel<\/a>\u00a0 \u00a0\u00a0<\/p>\n Cavaliers vs. Pistons over\/under:\u00a0 \u00a0\u00a0<\/p>\n 212.5 points<\/p>\n Cavaliers vs. Pistons money line:<\/p>\n Pistons -172, Cavaliers +144<\/p>\n Cavaliers vs. Pistons picks:\u00a0 \u00a0\u00a0<\/p>\n See picks at SportsLine<\/a><\/p>\n Cavaliers vs. Pistons streaming:<\/p>\n Fubo<\/a>\u00a0(Try for free) \u00a0<\/p>\n Top Cavaliers vs. Pistons predictions<\/p>\n After 10,000 simulations of Cavaliers vs. Pistons, SportsLine’s model is\u00a0going Under on the total (212.5).\u00a0The Under hit in three out of four meetings between these teams in the regular season and it hit in Games 1 and 2 in Detroit. The Pistons trended to the Under all season with 54% of its games hitting that side.\u00a0<\/p>\n The teams are projected to combine for 212 total points as the Under hits in 53% of simulations, making it a great selection for anybody targeting NBA parlay betting<\/a>. See the Cavaliers vs. Pistons spread pick at SportsLine<\/a>, and you can bet the Under in Pistons vs. Cavaliers at FanDuel here:<\/p>\n How to make Cavaliers vs. Pistons picks<\/p>\n After simulating each possession of Cavaliers vs. Pistons 10,000 times, the model also says one side of the spread hits nearly 70% of the time.\u00a0You can head to SportsLine to see the model’s NBA picks<\/a>.\u00a0<\/p>\n