{"id":700833,"date":"2026-05-29T04:53:29","date_gmt":"2026-05-29T04:53:29","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/700833\/"},"modified":"2026-05-29T04:53:29","modified_gmt":"2026-05-29T04:53:29","slug":"pleiotropic-effects-of-cis-regulatory-mutations","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/700833\/","title":{"rendered":"Pleiotropic effects of cis-regulatory mutations"},"content":{"rendered":"

Wray, G. A. The evolutionary significance of cis-regulatory mutations. Nat. Rev. Genet. 8, 206\u2013216 (2007).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wagner, G. P. & Lynch, V. J. The gene regulatory logic of transcription factor evolution. Trends Ecol. Evol. 23, 377\u2013385 (2008).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Vande Zande, P., Hill, M. S. & Wittkopp, P. J. Pleiotropic effects of trans-regulatory mutations on fitness and gene expression. Science 377, 105\u2013109 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sabar\u00eds, G., Laiker, I., Preger-Ben Noon, E. & Frankel, N. Actors with multiple roles: pleiotropic enhancers and the paradigm of enhancer modularity. Trends Genet. 35, 423\u2013433 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Laiker, I. & Frankel, N. Pleiotropic enhancers are ubiquitous regulatory elements in the human genome. Genome Biol. Evol. 14, evac071 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Singh, D. & Yi, S. V. Enhancer pleiotropy, gene expression, and the architecture of human enhancer-gene interactions. Mol. Biol. Evol. 38, 3898\u20133909 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gasperini, M. et al. A genome-wide framework for mapping gene regulation via cellular genetic screens. Cell 176, 377\u2013390.e19 (2019).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Huang, Y. et al. Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain. Genes Dev. 39, 348\u2013363 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wan, J. et al. Comprehensive mapping of genetic variation at Epromoters reveals pleiotropic association with multiple disease traits. Nucleic Acids Res. 53, gkae1270 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rajderkar, S. et al. Topologically associating domain boundaries are required for normal genome function. Commun. Biol. 6, 435 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Halfon, M. S. Studying transcriptional enhancers: the founder fallacy, validation creep, and other biases. Trends Genet. 35, 93\u2013103 (2019).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n","protected":false},"excerpt":{"rendered":"Wray, G. A. The evolutionary significance of cis-regulatory mutations. Nat. Rev. Genet. 8, 206\u2013216 (2007). Article\u00a0 CAS\u00a0 PubMed\u00a0…\n","protected":false},"author":2,"featured_media":700834,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[3878,3880,3875,49,48,3877,9867,1925,7821,3879,3673,3876,2780,66],"class_list":["post-700833","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science","tag-agriculture","tag-animal-genetics-and-genomics","tag-biomedicine","tag-ca","tag-canada","tag-cancer-research","tag-evolutionary-developmental-biology","tag-evolutionary-genetics","tag-gene-expression","tag-gene-function","tag-general","tag-human-genetics","tag-mutation","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/700833","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=700833"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/700833\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/700834"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=700833"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=700833"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=700833"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}