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<\/a><\/p>\nThe Aeion platform<\/a> follows the framework from the Sirio Institute of Aging, with eight concepts in geroprotection (preventive health for a younger demographic) and gerotherapy (helping to manage symptoms). These cover health areas like cellular and mitochondrial energy, joint health and mobility, metabolic health, and intestinal health.<\/p>\n Dr. YouYou Zhao, chief scientific officer, says the institute enabled the team to combine clinical science from professors, material science with Sirio\u2019s partners, and its own expertise in applications and engineering to create the Aeion platform.<\/p>\n Although Sirio observed a growing interest in longevity for many years, she says it has taken the company some time to create concepts that answer key questions on scientific evidence, traceability of materials, and finding the right applications.<\/p>\n \u201cThe second thing is traceability. There are many raw materials and cutting-edge sciences, but how can we trace whether these things remain stable throughout the whole manufacturing process? What is the shelf life? How stable are they all the way through the supply chain?\u201d<\/p>\n The final task to solve was applicability, says Zhao. \u201cWe want to offer something to customers and consumer brands that is not super expensive and inaccessible.\u201d<\/p>\n What is longevity?<\/p>\n Longevity and aging are often misunderstood, professor Richard Siow tells us. He is the director of Ageing Research at King\u2019s College London, UK. He says that aging is often seen as getting to a certain number, while longevity is understood as extending the lifespan.<\/p>\n However, he calls for a life-course approach to healthy aging, which does not only target older people with longevity solutions. \u201cWe need to start thinking about aging from the beginning of life.\u201d<\/p>\n \u201cYou\u2019ve probably heard the term health span. When does longevity start? When do we need to think about aging? From day one \u2014 from conception,\u201d he underscores. \u201cFor example, if you\u2019re born to a mother with diabetes during pregnancy, that already increases your rate of aging and your risk of age-related diseases before birth.\u201d<\/p>\n Moreover, Siow notes that age-related conditions are informed by genetics as well. He also highlights the role of epigenetic programming, where environmental factors like diet and stress alter gene expression, without changing DNA.<\/p>\n \u201cThe body changes through puberty, early years and growth, pregnancy, and menopause. Different regions also have different habits; what may work in China may not work in Southern Europe.\u201d<\/p>\n Measuring effectiveness<\/p>\n To determine whether interventions can help expand the health span, Siow highlights the importance of biomarkers to measure a person\u2019s biological age. Whether a product makes a difference is crucial for consumers to keep taking a product.<\/p>\n \u201cWe\u2019re working on biomarkers that are easy and cheap, for example, so consumers don\u2019t have to go to a clinic to have liters of blood drained.\u201d<\/p>\n He points to saliva and urine as examples of consumer biomarkers that can be measured easily and cheaply, for example, with a lateral flow device like COVID-19 tests or a urine stick.<\/p>\n \u201cWhat can we measure? For example, saliva samples can pick up epigenetics, maybe not as accurately, but it gives you a picture of whether something over a week or a month made a difference.\u201d<\/p>\n Product development process<\/p>\n Janine Barlow, head of R&D at Sirio Europe, details the company\u2019s product development process. This starts with market research to determine where the market is heading and what the company aims to target. Next, Sirio determines effective ingredients for these targets through scientific research.<\/p>\n \u201cThen we determine if we need to consider how to deliver these ingredients effectively into the body,\u201d she adds. \u201cIt\u2019s not a long-term pharmaceutical development process, but it\u2019s with that mindset so our customers can bring market-leading, efficacious products to the market.\u201d<\/p>\n Moreover, she says that while the longevity formulations each cover a specific health area, some include ingredients that provide more than one benefit. \u201cFor example, our metabolic health product contains ADM\u2019s BPL1 postbiotic, with evidence around weight management, cardiovascular protection, and lowering blood glucose levels.\u201d<\/p>\n For example, one of the dosage formats in the Aeion platform is a LifeChew, a pectin-based jelly tablet<\/a>. Barlow says this format has been shown to improve the bioavailability of docosahexaenoic acid compared to some other formats.<\/p>\n Fun formats for daily habits<\/p>\n Alex Dens, sales director, highlights that Sirio approaches longevity in a multi-layered way, designing a \u201csystem of habits\u201d with the eight product concepts in the Aeion platform<\/a> that offers customers a range of options in dosage formats and health benefits.<\/p>\n \u201cMore importantly, we need to provide options so the end consumer can integrate these products into daily habits.\u201d<\/p>\n Dens underscores the importance of building those rituals, because longevity solutions will not work if consumers only take them for a few months or years. \u201cWe\u2019re really talking about a lifelong approach.\u201d<\/p>\nAt Vitafoods Europe 2026, Maria Pavlidou told us how the Aeion longevity platform helps build healthy habits.<\/a>First, the contract development and manufacturing organization aimed to determine what is truly evidence-based. \u201cIt\u2019s not just science or best wishes,\u201d says Zhao. \u201cPeople talk about mitochondria and cellular systems, but how do these link to final endpoint evidence in terms of clinical data?\u201d<\/p>\n
Siow calls for a life-course approach to healthy aging, where consumers start thinking about aging from the beginning of life.He adds that healthy aging is not \u201cone-size-fits-all,\u201d and is more than taking one supplement throughout someone\u2019s whole life. Products and evidence for lifestyle interventions need to be context-specific for different age groups and genders.<\/p>\n
The Aeion platform includes eight product concepts in geroprotection and gerotherapy, such as cellular energy and mobility.\u201cWhen we\u2019re choosing a health benefit area, we need to consider what\u2019s the best format for a consumer to take this,\u201d Barlow details. \u201cIt\u2019s important to consider the dosage format in the early stage of that development process, which would also help drive efficacy for the product as well.\u201d<\/p>\n