{"id":710093,"date":"2026-06-02T13:39:08","date_gmt":"2026-06-02T13:39:08","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/710093\/"},"modified":"2026-06-02T13:39:08","modified_gmt":"2026-06-02T13:39:08","slug":"how-embryos-shape-their-limbs-a-key-discovery-of-genetic-brakes","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/710093\/","title":{"rendered":"How embryos shape their limbs: a key discovery of \u201cgenetic brakes\u201d\u202f"},"content":{"rendered":"<p>\u201cThis discovery illustrates how development relies on finely tuned and precise orchestration of gene expression,&#8221; said IRCM president and scientific director Jean-Fran\u00e7ois C\u00f4t\u00e9.\u00a0<\/p>\n<p>&#8220;Understanding these mechanisms is essential to better grasp the origin of certain malformations.&#8221;\u00a0<\/p>\n<p>Beyond limb formation, these findings reveal a fundamental principle of development: cells must not only activate the right\u202fgenes, but\u202falso remember which ones must remain switched off. This regulatory system helps prevent errors that could lead to congenital abnormalities.\u202f\u00a0<\/p>\n<p>The next step in Kmita&#8217;s research will be to\u202fidentify\u202fthe signals that guide the recruitment of these\u202fPolycomb\u202fcomplexes to the right genes at the right time\u2014a key question for deepening scientists&#8217; understanding of embryonic development and its dysregulation.<\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"\u201cThis discovery illustrates how development relies on finely tuned and precise orchestration of gene expression,&#8221; said IRCM president&hellip;\n","protected":false},"author":2,"featured_media":710094,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[13927,49,48,59812,97286,316,257832,257833,257831,994,66],"class_list":["post-710093","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science","tag-biology","tag-ca","tag-canada","tag-department-of-medicine","tag-faculty-of-medicine","tag-genetics","tag-institut-de-recherches-cliniques-de-montreal","tag-ircm","tag-marie-kmita","tag-research","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/710093","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=710093"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/710093\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/710094"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=710093"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=710093"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=710093"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}