{"id":816861,"date":"2026-07-21T18:17:36","date_gmt":"2026-07-21T18:17:36","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/816861\/"},"modified":"2026-07-21T18:17:36","modified_gmt":"2026-07-21T18:17:36","slug":"ai-powered-closed-loop-wearable-bioelectronics-for-personalized-and-autonomous-healthcare","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/816861\/","title":{"rendered":"AI-powered closed-loop wearable bioelectronics for personalized and autonomous healthcare"},"content":{"rendered":"

Chen, C., Ding, S. & Wang, J. Digital health for aging populations. Nat. Med. 29, 1623\u20131630 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Paci, M. M. et al. Smart closed-loop drug delivery systems. Nat. Rev. Bioeng. 3, 816\u2013834 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Choi, Y. S. et al. A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy. Science 376, 1006\u20131012 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jiang, Y. et al. Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing. Nat. Biotechnol. 41, 652\u2013662 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhang, Q. et al. A prototype closed-loop brain-machine interface for the study and treatment of pain. Nat. Biomed. Eng. 7, 533\u2013545 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wei, Y. et al. Integrated individually addressable microneedle arrays for robust glucose monitoring and on-demand insulin releasing. Microsyst. Nanoeng. 11, 211 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zou, Y. et al. A closed-loop bioelectronic patch for intelligent blood pressure management. Sci. Adv. 11, eadx6438 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gu, G. et al. A soft neuroprosthetic hand providing simultaneous myoelectric control and tactile feedback. Nat. Biomed. Eng. 7, 589\u2013598 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chen, S. et al. Transforming healthcare: intelligent wearable sensors empowered by smart materials and artificial intelligence. Adv. Mater. 37, 2500412 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang, G. et al. Optimized glycemic control of type 2 diabetes with reinforcement learning: a proof-of-concept trial. Nat. Med. 29, 2633\u20132642 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ding, S. et al. Artificial intelligence-enabled wearable microgrids for self-sustained energy management. Nat. Rev. Electr. Eng. 2, 683\u2013693 (2025).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wei, X. et al. Wirelessly controlled drug delivery systems for translational medicine. Nat. Rev. Electr. Eng. 2, 244\u2013262 (2025).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chen, E., Prakash, S., Janapa Reddi, V., Kim, D. & Rajpurkar, P. A framework for integrating artificial intelligence for clinical care with continuous therapeutic monitoring. Nat. Biomed. Eng. 9, 445\u2013454 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Akkas, T. et al. The role of artificial intelligence in advancing biosensor technology: past, present, and future perspectives. Adv. Mater. 37, 2504796 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mahato, K. et al. Hybrid multimodal wearable sensors for comprehensive health monitoring. Nat. Electron. 7, 735\u2013750 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Huang, Y. et al. Bioelectronics for electrical stimulation: materials, devices and biomedical applications. Chem. Soc. Rev. 53, 8632\u20138712 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chang, A.-Y. et al. Integration of chemical and physical inputs for monitoring metabolites and cardiac signals in diabetes. Nat. Biomed. Eng. https:\/\/doi.org\/10.1038\/s41551-025-01439-z<\/a> (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Qazi, R. et al. Wireless optofluidic brain probes for chronic neuropharmacology and photostimulation. Nat. Biomed. Eng. 3, 655\u2013669 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wu, Y. et al. Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology. Nat. Commun. 13, 5571 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yoon, Y. et al. Neural probe system for behavioral neuropharmacology by bi-directional wireless drug delivery and electrophysiology in socially interacting mice. Nat. Commun. 13, 5521 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang, L. et al. A biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuries. Nat. Commun. 16, 1716 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang, Y. et al. Digital automation of transdermal drug delivery with high spatiotemporal resolution. Nat. Commun. 15, 511 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Huang, X. et al. A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage. Nat. Commun. 16, 5782 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ouyang, W. et al. A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals. Nat. Biomed. Eng. 7, 1252\u20131269 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Gao, Y. et al. A flexible multiplexed immunosensor for point-of-care in situ wound monitoring. Sci. Adv. 7, eabg9614 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xu, C. et al. A physicochemical-sensing electronic skin for stress response monitoring. Nat. Electron. 7, 168\u2013179 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang, M. et al. Printable molecule-selective core-shell nanoparticles for wearable and implantable sensing. Nat. Mater. https:\/\/doi.org\/10.1038\/s41563-024-02096-4<\/a> (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Shin, J. et al. A non-contact wearable device for monitoring epidermal molecular flux. Nature 640, 375\u2013383 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhou, Z. et al. Machine learning-powered wearable interface for distinguishable and predictable sweat sensing. Biosens. Bioelectron. 265, 116712 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fang, Y. et al. Ambulatory cardiovascular monitoring via a machine-learning-assisted textile triboelectric sensor. Adv. Mater. 33, e2104178 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Luo, Y. et al. Technology roadmap for flexible sensors. ACS Nano 17, 5211\u20135295 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Li, Q. et al. A smart semi-implantable device integrating microchannel-enhanced sampling and multiplex biochemical testing for deep wound monitoring and pathogen identification. Adv Sci (Weinh) 12, e2407868 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xiao, J., Zhou, Z., Zhong, G., Xu, T. & Zhang, X. Self-sterilizing microneedle sensing patches for machine learning-enabled wound pH visual monitoring. Adv. Funct. Mater. 34, 2315067 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Arwani, R. T. et al. Stretchable ionic\u2013electronic bilayer hydrogel electronics enable in situ detection of solid-state epidermal biomarkers. Nat. Mater. 23, 1115\u20131122 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Li, N. et al. Bioadhesive polymer semiconductors and transistors for intimate biointerfaces. Science 381, 686\u2013693 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhao, C. et al. Skin-like drift-free biosensors with stretchable diode-connected organic field-effect transistors. Nat. Electron. 8, 981\u2013993 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Dai, Y. et al. Soft hydrogel semiconductors with augmented biointeractive functions. Science 386, 431\u2013439 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhang, S., Suresh, L., Yang, J., Zhang, X. & Tan, S. C. Augmenting sensor performance with machine learning towards smart wearable sensing electronic systems. Adv. Intell. Syst. 4, 2100194 (2022).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jin, T. et al. A wireless operated flexible bioelectronic microneedle patch for actively controlled transdermal drug delivery. Adv. Mater. 37, 2417136 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xu, G. et al. Battery-free and wireless smart wound dressing for wound infection monitoring and electrically controlled on-demand drug delivery. Adv. Funct. Mater. 31, 2100852 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Liu, Y., Yu, Q., Ye, L., Yang, L. & Cui, Y. A wearable, minimally-invasive, fully electrochemically-controlled feedback minisystem for diabetes management. Lab Chip 23, 421\u2013436 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang, H. et al. A wearable transdermal device for on-demand drug delivery. Matter https:\/\/doi.org\/10.1016\/j.matt.2025.102040<\/a> (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Guan, K. et al. A peri-wound wearable system for dual-modal monitoring and management of healing dynamics. Biosens. Bioelectron. 296, 118344 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Huang, S. et al. Soft implantation of flexible electronic hairs via tip-focused radiofrequency perforation for in-tissue electrophysiology. Nat. Sens. https:\/\/doi.org\/10.1038\/s44460-025-00004-0<\/a> (2026).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sun, Z. et al. A bioabsorbable body-coupling-electrotherapy suture. Nat. Commun. https:\/\/doi.org\/10.1038\/s41467-025-66045-8<\/a> (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jin, S. et al. Injectable tissue prosthesis for instantaneous closed-loop rehabilitation. Nature 623, 58\u201365 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lee, S. et al. A shape-morphing cortex-adhesive sensor for closed-loop transcranial ultrasound neurostimulation. Nat. Electron. 7, 800\u2013814 (2024).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yao, G. et al. A programmable and skin temperature\u2013activated electromechanical synergistic dressing for effective wound healing. Sci. Adv. 8, eabl8379 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Liu, Z. et al. Wireless intelligent patch for closed-loop in situ wound management. Adv. Sci. 11, 2400451 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Li, H. et al. Towards adaptive bioelectronic wound therapy with integrated real-time diagnostics and machine learning\u2013driven closed-loop control. npj Biomed. Innov. 2, 31 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bhave, G., Chen, J. C., Singer, A., Sharma, A. & Robinson, J. T. Distributed sensor and actuator networks for closed-loop bioelectronic medicine. Mater. Today 46, 125\u2013135 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhang, R. et al. Adaptive drug delivery to control mean arterial blood pressure by reinforcement fuzzy Q-learning. IEEE Sens. J. 24, 30968\u201330977 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Song, J. W. et al. Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites. Sci. Adv. 9, eade4687 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Shirzaei Sani, E. et al. A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds. Sci. Adv. 9, eadf7388 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Huang, W. et al. Artificial intelligence-enhanced, closed-loop wearable systems toward next-generation diabetes management. Adv. Intell. Syst. https:\/\/doi.org\/10.1002\/aisy.202400822<\/a> (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kim, J., Lee, S., Yoon, J. & Son, D. Soft sensory-neuromorphic system for closed-loop neuroprostheses. Int. J. Extrem. Manuf. 7, 042001 (2025).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang, B. et al. Organic electrochemical transistors for integrated sensing\u2013memory\u2013computing hardware towards intelligent Internet of Bodies. Nat. Rev. Electr. Eng. https:\/\/doi.org\/10.1038\/s44287-025-00234-x<\/a> (2025).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lin, R. et al. A flexible wireless skin patch for synchronized glucose monitoring and regulation. Microsyst. Nanoeng. 12, 23 (2026).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Xu, X. et al. Implantable photoelectrochemical-therapeutic methotrexate monitoring system with dual-atomic docking strategy. Nat. Commun. 16, 1747 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Liu, S. et al. A bio-feedback-mimicking electrode combining real-time monitoring and drug delivery. Innovation (Camb) 5, 100705 (2024).<\/p>\n

CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bailey, T. S. et al. Evaluation of accuracy and safety of the 365-day implantable Eversense continuous glucose monitoring system: The ENHANCE Study. Diabetes Technol. Ther. 27, 407\u2013411 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Liu, Y., Yang, L. & Cui, Y. A wearable, rapidly manufacturable, stability-enhancing microneedle patch for closed-loop diabetes management. Microsyst. Nanoeng. 10, 112 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Nimri, R. et al. Insulin dose optimization using an automated artificial intelligence-based decision support system in youths with type 1 diabetes. Nat. Med. 26, 1380\u20131384 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Qu, J. et al. Multifunctional hydrogel electronics for closed-loop antiepileptic treatment. Sci. Adv. 10, eadq9207 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lucas, A., Revell, A. & Davis, K. A. Artificial intelligence in epilepsy\u2014applications and pathways to the clinic. Nat. Rev. Bioeng. 20, 319\u2013336 (2024).<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jafari, M. et al. Merging machine learning and bioelectronics for closed-loop control of biological systems and homeostasis. Cell Rep. Phys. Sci. 4, 101535 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zlobina, K., Jafari, M., Rolandi, M. & Gomez, M. The role of machine learning in advancing precision medicine with feedback control. Cell Rep. Phys. Sci. 3, 101149 (2022).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mai, V. T., Alattas, K. A., Bouteraa, Y., Ghaderpour, E. & Mohammadzadeh, A. Personalized blood pressure control by machine learning for remote patient monitoring. IEEE Access 12, 83994\u201384004 (2024).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rajpurkar, P., Chen, E., Banerjee, O. & Topol, E. J. AI in health and medicine. Nat. Med. 28, 31\u201338 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

MacIsaac, C., Nguyen, M., Uy, A., Kong, T. & Hedayatipour, A. A programmable gain calibration method to mitigate skin tone bias in PPG sensors. Biosensors 15, 423 (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhang, A., Xing, L., Zou, J. & Wu, J. C. Shifting machine learning for healthcare from development to deployment and from models to data. Nat. Biomed. Eng. 6, 1330\u20131345 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Benjamens, S., Dhunnoo, P. & Mesk\u00f3, B. The state of artificial intelligence-based FDA-approved medical devices and algorithms: an online database. npj Digit. Med. 3, 118 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kelly, C. J., Karthikesalingam, A., Suleyman, M., Corrado, G. & King, D. Key challenges for delivering clinical impact with artificial intelligence. BMC Med. 17, 195 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Wang, M. et al. Fusing stretchable sensing technology with machine learning for human\u2013machine interfaces. Adv. Funct. Mater. 31, 2008807 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhuang, Q. et al. Permeable, three-dimensional integrated electronic skins with stretchable hybrid liquid metal solders. Nat. Electron. https:\/\/doi.org\/10.1038\/s41928-024-01189-x<\/a> (2024).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Qi, J., Gao, F., Sun, G., Yeo, J. C. & Lim, C. T. HaptGlove-untethered pneumatic glove for multimode haptic feedback in reality-virtuality vontinuum. Adv. Sci. 10, e2301044 (2023).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Yu, X. et al. Skin-integrated wireless haptic interfaces for virtual and augmented reality. Nature 575, 473\u2013479 (2019).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ha, K.-H. et al. Full freedom-of-motion actuators as advanced haptic interfaces. Science 387, 1383\u20131390 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Li, X. et al. A fully integrated closed-loop system based on mesoporous microneedles-iontophoresis for diabetes treatment. Adv Sci (Weinh) 8, e2100827 (2021).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Daly, A. B. et al. Fully automated closed-loop insulin delivery in adults with type 2 diabetes: an open-label, single-center, randomized crossover trial. Nat. Med. 29, 203\u2013208 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Li, S. et al. Monitoring blood pressure and cardiac function without positioning via a deep learning\u2013assisted strain sensor array. Sci. Adv. 9, eadh0615 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Tsoi, K. et al. Applications of artificial intelligence for hypertension management. J. Clin. Hypertens. 23, 568\u2013574 (2021).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mackenzie, S. C., Sainsbury, C. A. R. & Wake, D. J. Diabetes and artificial intelligence beyond the closed loop: a review of the landscape, promise and challenges. Diabetologia 67, 223\u2013235 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhao, S. et al. A wearable osmotic microneedle patch provides high-capacity sustained drug delivery in animal models. Sci. Transl. Med. 16, eadp3611 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kang, W. et al. Closed-loop direct control of seizure focus in a rodent model of temporal lobe epilepsy via localized electric fields applied sequentially. Nat. Commun. 13, 7805 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Liu, J. et al. Flexible bioelectronic systems with large-scale temperature sensor arrays for monitoring and treatments of localized wound inflammation. Proc. Natl Acad. Sci. USA 121, e2412423121 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Boughton, C. K. & Hovorka, R. Advances in artificial pancreas systems. Sci. Transl. Med. 11, eaaw4949 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kassiri, H., Muneeb, A., Salahi, R. & Dabbaghian, A. Closed-loop implantable neurostimulators for individualized treatment of intractable epilepsy: a review of recent developments, ongoing challenges, and future opportunities. IEEE Trans. Biomed. Circuits Syst. 18, 1268\u20131295 (2024).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Cruz Rivera, S. et al. Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension. Lancet Digit. Health 2, e549\u2013e560 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Liu, X. et al. Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension. Lancet Digit. Health 2, e537\u2013e548 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Battelino, T. et al. Clinical targets for continuous glucose monitoring data interpretation: recommendations from the international consensus on time in range. Diabetes Care 42, 1593\u20131603 (2019).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Corrigan-Curay, J., Sacks, L. & Woodcock, J. Real-world evidence and real-world data for evaluating drug safety and effectiveness. JAMA 320, 867\u2013868 (2018).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Emmons, N. A. et al. Feedback control over plasma drug concentrations achieves rapid and accurate control over solid-tissue drug concentrations. ACS Pharmacol. Transl. Sci. https:\/\/doi.org\/10.1021\/acsptsci.5c00142<\/a> (2025).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Phillips, A. A. et al. An implantable system to restore hemodynamic stability after spinal cord injury. Nat. Med. 31, 2946\u20132957 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kang, K. et al. Bionic artificial skin with a fully implantable wireless tactile sensory system for wound healing and restoring skin tactile function. Nat. Commun. 15, 10 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhao, H. et al. A closed-loop smart dressing based on microneedle and electrochemical micropump for early diagnosis and in-time therapy of chronic wound. Sens. Actuat. B Chem. 417, 136092 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Baker, S. et al. Ethical considerations in closed loop deep brain stimulation. Deep Brain Stimul. 3, 8\u201315 (2023).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Lou, D. et al. Flexible wound healing system for pro-regeneration, temperature monitoring and infection early warning. Biosens. Bioelectron. 162, 112275 (2020).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Fox, D. S. et al. Cost-effectiveness of closed-loop automated insulin delivery using the Cambridge hybrid algorithm in children and adolescents with type 1 diabetes: results from a multicenter 6-month randomized trial. J. Diabetes Sci. Technol. 19, 982\u2013991 (2025).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Asgharzadeh, A. et al. Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling. Health Technol. Assess. 28, 80 (2024).<\/p>\n


\n Google Scholar<\/a>\u00a0\n <\/p>\n

Jendle, J. & Reznik, Y. Use of insulin pumps and closed-loop systems among people living with diabetes: A narrative review of clinical and cost-effectiveness to enable access to technology and meet the needs of payers. Diabetes Obes. Metab. 25, 21\u201332 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Topol, E. J. High-performance medicine: the convergence of human and artificial intelligence. Nat. Med. 25, 44\u201356 (2019).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Rieke, N. et al. The future of digital health with federated learning. npj Digit. Med. 3, 119 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Bergenstal, R. M. et al. Safety of a hybrid closed-loop insulin delivery system in patients with type 1 diabetes. JAMA 316, 1407\u20131408 (2016).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chen, B. et al. Artificial intelligence-assisted high-throughput screening of printing conditions of hydrogel architectures for accelerated diabetic wound healing. Adv. Funct. Mater. 32, 2201843 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sherr, J. L. et al. Automated insulin delivery: benefits, challenges, and recommendations. a consensus report of the Joint Diabetes Technology Working Group of the European Association for the Study of Diabetes and the American Diabetes Association. Diabetes Care 45, 3058\u20133074 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Kim, J., Campbell, A. S., de \u00c1vila, B. E.-F. & Wang, J. Wearable biosensors for healthcare monitoring. Nat. Biotechnol. 37, 389\u2013406 (2019).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Acosta, J. N., Falcone, G. J., Rajpurkar, P. & Topol, E. J. Multimodal biomedical AI. Nat. Med. 28, 1773\u20131784 (2022).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sempionatto, J. R. et al. An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers. Nat. Biomed. Eng. 5, 737\u2013748 (2021).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Pavan, J., Salvagnin, D., Facchinetti, A., Sparacino, G. & Favero, S. D. Incorporating sparse and quantized carbohydrates suggestions in model predictive control for artificial pancreas in type 1 diabetes. IEEE Trans. Control Syst. Technol. 31, 570\u2013586 (2023).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ge, Z. et al. Wireless and closed-loop smart dressing for exudate management and on-demand treatment of chronic wounds. Adv. Mater. https:\/\/doi.org\/10.1002\/adma.202304005<\/a> (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Schamberg, G., Badgeley, M., Meschede-Krasa, B., Kwon, O. & Brown, E. N. Continuous action deep reinforcement learning for propofol dosing during general anesthesia. Artif. Intell. Med. 123, 102227 (2022).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Sharma, R., Deepak, K. K., Gaur, P. & Joshi, D. An optimal interval type-2 fuzzy logic control based closed-loop drug administration to regulate the mean arterial blood pressure. Comput. Methods Programs Biomed. 185, 105167 (2020).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zheng, X. T. et al. Battery-free and AI-enabled multiplexed sensor patches for wound monitoring. Sci. Adv. 9, eadg6670 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ding, S. et al. A fingertip-wearable microgrid system for autonomous energy management and metabolic monitoring. Nat. Electron. https:\/\/doi.org\/10.1038\/s41928-024-01236-7<\/a> (2024).<\/p>\n

Article<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Zhou, Y. et al. An integrated Mg battery-powered iontophoresis patch for efficient and controllable transdermal drug delivery. Nat. Commun. 14, 297 (2023).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Mosquera-Lopez, C. et al. Enabling fully automated insulin delivery through meal detection and size estimation using Artificial Intelligence. npj Digit. Med. 6, 39 (2023).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Little, S. et al. Adaptive deep brain stimulation in advanced Parkinson disease. Ann. Neurol. 74, 449\u2013457 (2013).<\/p>\n

Article<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Chen, Z. et al. A self-powered controllable microneedle drug delivery system for rapid blood pressure reduction. Nano Energy 123, 109344 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n

Ciatti, J. L. et al. An autonomous implantable device for the prevention of death from opioid overdose. Sci. Adv. 10, eadr3567 (2024).<\/p>\n

Article<\/a>\u00a0
\n CAS<\/a>\u00a0
\n PubMed<\/a>\u00a0
\n PubMed Central<\/a>\u00a0
\n
\n Google Scholar<\/a>\u00a0\n <\/p>\n","protected":false},"excerpt":{"rendered":"Chen, C., Ding, S. & Wang, J. Digital health for aging populations. Nat. Med. 29, 1623\u20131630 (2023). Article\u00a0…\n","protected":false},"author":2,"featured_media":816862,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[29125,29360,4468,49,48,11097,84,392,3677,15597],"class_list":["post-816861","post","type-post","status-publish","format-standard","has-post-thumbnail","category-healthcare","tag-biomedical-engineering","tag-biomedical-engineering-biotechnology","tag-biotechnology","tag-ca","tag-canada","tag-electrical-and-electronic-engineering","tag-health","tag-healthcare","tag-nanotechnology","tag-optical-and-electronic-materials"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/816861","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=816861"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/816861\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/816862"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=816861"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=816861"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=816861"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}