The wait is officially over. Sportsbooks and prediction markets across the continent have released opening odds for Week 1 of the 2026 NFL regular season, giving bettors and football fans their first look at point spreads, moneyline prices, and totals across the full 16-game slate.<\/p>\n
From marquee primetime showdowns to heated divisional clashes, Week 1 features compelling betting angles from top to bottom. The slate kicks off with a rare Wednesday opener \u2013 that\u2019s also a Super Bowl 60 rematch \u2013 and rolls through Thursday night before a loaded 13-game Sunday schedule and a Monday night finale.<\/p>\n
The table below lists the complete odds for all 16 matchups in Week 1 (in chronological order).<\/p>\n
Opening NFL Week 1 Odds <\/p>\n
Seahawks vs Patriots Opening Odds<\/p>\n
The 2026 campaign kicks off in Seattle with an intriguing interconference matchup on Wednesday, September 9th. DraftKings opens the defending Super Bowl-champ Seahawks as\u00a03.5-point home favorites (-105)\u00a0with a moneyline price of\u00a0-185, while the visiting Patriots \u2013 the team Seattle beat in last year\u2019s title game \u2013 sit as\u00a0+3.5 underdogs (-115)\u00a0and\u00a0+154\u00a0to win outright.<\/p>\n
The total is listed at\u00a044.5 points, with slight juice to the Under (-115), indicating oddsmakers expect a physical, field-position battle early in the year as both units shake off offseason rust. Seattle won the 2026 Super Bowl 29-13 (42 total points) but the teams combined for just 12 points in the first three quarters. <\/p>\n
Seattle opens the season as the fourth-favorite in the Super Bowl 61 odds<\/a>, trailing the division-rival Rams (+550) plus a pair of AFC powers: the Bills (+1000) and Ravens (+1000). <\/p>\n Rams vs 49ers Opening Odds<\/p>\n Speaking of the Rams, the favorites for the Lombardi Trophy open the new campaign on Thursday night in a high-stakes NFC West clash with the San Francisco 49ers at SoFi Stadium. The first TNF odds<\/a> of the season install the Rams as\u00a03.5-point home favorites (-108)\u00a0with a\u00a0-185 moneyline, while the 49ers come in catching the hook at\u00a0+3.5 (-112)\u00a0and\u00a0+154 on the moneyline.<\/p>\n The total of\u00a048.5 points\u00a0is among the highest on the Week 1 slate, signaling confidence in both offensive schemes to find early-season rhythm. Bettors siding with San Francisco will appreciate landing more than a field goal in a matchup that routinely comes down to the final possession.<\/p>\n Chiefs vs Broncos Opening Odds<\/p>\n Week 1 wraps with an intense AFC West showdown at Arrowhead Stadium between the Kansas City Chiefs and Denver Broncos. Kansas City enters as a\u00a03.0-point home favorite (+100)\u00a0with a\u00a0-148 moneyline, while Denver travels as a\u00a0+3.0 underdog (-120)\u00a0and\u00a0+124 on the moneyline.<\/p>\n The flat three-point spread with extra juice on Denver\u2019s side highlights respect for the Broncos\u2019 defense against a KC team that might not have Patrick Mahomes operating at 100%. With a total set at\u00a042.5 points, sportsbooks anticipate a tight, grind-it-out divisional battle where every point in the fourth quarter will matter.<\/p>\n