{"id":890568,"date":"2026-09-10T14:20:31","date_gmt":"2026-09-10T14:20:31","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/890568\/"},"modified":"2026-09-10T14:20:31","modified_gmt":"2026-09-10T14:20:31","slug":"scientists-explore-dna-damage-in-prostate-cancer-for-better-predictions-healthcare-in-europe-com","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/890568\/","title":{"rendered":"Scientists explore DNA damage in prostate cancer for better predictions \u2022 healthcare-in-europe.com"},"content":{"rendered":"<p><a class=\"fancybox content-img\" rel=\"fancybox nofollow noopener\" href=\"https:\/\/healthcare-in-europe.com\/media\/story_section_text\/46309\/image-01-barbara-hernando-portrait_hires.jpg\" title=\"Barbara Hernando\" target=\"_blank\"><img decoding=\"async\" src=\"https:\/\/www.newsbeep.com\/ca\/wp-content\/uploads\/2026\/09\/image-01-barbara-hernando-portrait.jpg\" alt=\"Portrait photo of Barbara Hernando\" \/><\/a><\/p>\n<p>Barbara Hernando<\/p>\n<p>\u201cWhat surprised us most was the sheer scale of the damage coming from inside the cell,\u201d says Barbara Hernando, a researcher at the CNIO and one of the study\u2019s four joint first authors. \u201cWe looked for the marks that tobacco, sunlight and other external agents leave on DNA, the way you can read them in lung or skin cancer. Across almost a thousand genomes, we found practically none.\u201d That does not mean environmental exposures or lifestyle are irrelevant to prostate cancer. \u201cDiet, weight and inflammation can all influence whether prostate cancer develops without leaving any trace in the DNA,\u201d Hernando adds.\u00a0<\/p>\n<p>The work brings the prospect of reliable prognostic markers closer. The analysis showed, for instance, that when one particular faulty process was the most active, the cancer was more likely to spread. That pattern held after taking into account age, tumour stage and the grade a pathologist assigns to a tumour under the microscope.\u00a0<\/p>\n<p>The team was also able to link one active process to a small group of patients who responded better to a specific type of therapy. That finding came from 25 men, and was examined after the fact rather than in a trial designed to test it.\u00a0<\/p>\n<p>These results offer clues that could help stratify patients and personalise treatment \u2013 but not yet. \u201cBefore this reaches a hospital, the findings have to be confirmed in other groups of patients,\u201d says Macintyre. \u201cThe measurement then has to become a test that gives the same answer every time. That test has to be trialled in men who are making real decisions about their treatment. And it has to be shown to help them.\u201d\u00a0<\/p>\n<p>\u201cWe have created a map of the biological processes that drive prostate cancer,\u201d says Joachim Weischenfeldt, professor at the Biotech Research and Innovation Centre of the University of Copenhagen and Rigshospitalet, who co-led the study. \u201cIt is not going to change how any man is treated tomorrow. But it runs on the kind of DNA sequencing that several health systems already carry out for cancer patients. What we are proposing is to read existing data differently, not to build a new test from scratch.\u201d\u00a0<\/p>\n<p>Source: Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO)<\/p>\n","protected":false},"excerpt":{"rendered":"Barbara Hernando \u201cWhat surprised us most was the sheer scale of the damage coming from inside the cell,\u201d&hellip;\n","protected":false},"author":2,"featured_media":890569,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[49,48,308702,84],"class_list":["post-890568","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-ca","tag-canada","tag-co-led-by-the-spanish-national-cancer-research-centre-amigosdelcnio-brco-led-by-cniostopcancer-bsky-social","tag-health"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/890568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=890568"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/890568\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/890569"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=890568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=890568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=890568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}