{"id":891054,"date":"2026-09-10T23:18:13","date_gmt":"2026-09-10T23:18:13","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/891054\/"},"modified":"2026-09-10T23:18:13","modified_gmt":"2026-09-10T23:18:13","slug":"49ers-vs-rams-prediction-odds-nfl-australia-game-picks-from-10000-simulations","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/891054\/","title":{"rendered":"49ers vs. Rams prediction, odds: NFL Australia game picks from 10,000 simulations"},"content":{"rendered":"

NFC West contenders open their regular seasons when the San Francisco 49ers<\/a> battle the Los Angeles Rams<\/a> in the 2026 NFL Australia Week 1 matchup in Melbourne on Thursday. Both teams tied for second in the division with 12-5 records last year. The Rams fell short to the eventual champion Seattle Seahawks 31-27 in the NFC Championship Game. The Niners also were eliminated by the Seahawks, losing 41-6 in a divisional round matchup. Aaron Donald will not play for the Rams this week as he continues to condition following his return from a two-year retirement.\u00a0New to sports trading? Visit our\u00a0Kalshi promo code<\/a>\u00a0review and\u00a0get a $25 bonus after $25+ in trades with the Kalshi promo code CBSSPORTS<\/a>:<\/p>\n

Kickoff is at 8:35 p.m. ET from Melbourne Cricket Ground, where the local time is 10:35 a.m. on Friday morning. The latest Rams vs. 49ers odds have Los Angeles as 3.5-point favorites, while the over\/under for total points scored is 48.5. The Over went a combined 23-15-1 for the teams across last year’s regular and postseason. Before making any 49ers vs. Rams picks, be sure to\u00a0see the NFL Australia game predictions from SportsLine’s projection model<\/a>.<\/p>\n

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on\u00a0betting sites<\/a>\u00a0on top-rated\u00a0NFL picks<\/a>\u00a0since its inception. The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024. Anybody following its picks at\u00a0NFL betting sites<\/a>\u00a0could have seen strong returns.<\/p>\n

Now, the model has zeroed in on 49ers vs. Rams<\/a>. You can head to SportsLine now to see its picks.<\/a> Here are several NFL odds<\/a> and betting lines for Rams vs. 49ers:<\/p>\n

49ers vs. Rams spread<\/p>\n

Rams -3.5\u00a0<\/p>\n

49ers vs. Rams over\/under<\/p>\n

48.5 points<\/p>\n

49ers vs. Rams money line\u00a0<\/p>\n

Rams -205, 49ers +172<\/p>\n

49ers vs. Rams picks<\/p>\n

See picks at SportsLine<\/a><\/p>\n

49ers vs. Rams streaming\u00a0<\/p>\n

Netflix<\/p>\n

Visit our\u00a0Polymarket promo code<\/a> review and\u00a0get a $50 sign-up bonus as a new user after a $10 deposit here<\/a>:<\/p>\n

Top 49ers vs. Rams predictions<\/p>\n

After 10,000 simulations of 49ers vs. Rams, the model is\u00a0going Over 48.5 combined points at\u00a0betting apps<\/a>. The Rams and their opponents combined to score 49 or more points in 12 of 20 games, including the postseason. Los Angeles averaged a league-best 30.5 points a year ago. San Francisco was 10th in scoring in 2025, averaging 25.7 points.<\/p>\n

San Francisco’s Brock Purdy<\/a> is projected to throw for more than 220 yards and one touchdown. Los Angeles’ Matthew Stafford<\/a>, meanwhile is projected to throw for over 235 yards and two touchdowns. SportsLine’s model projects 49 combined points between the 49ers and Rams.\u00a0See which team to back at SportsLine<\/a>.<\/p>\n

How to make 49ers vs. Rams picks<\/p>\n

In addition to going Over on the total, the model also says one side of the spread hits nearly 60% of the time.\u00a0See what it is at SportsLine<\/a>.<\/p>\n

Who wins 49ers vs. Rams, and which side of the spread hits in nearly 60% of simulations?\u00a0Visit SportsLine now to see which side of the 49ers vs. Rams spread you need to jump, all from the model that is 53-37 on top-rated picks since 2024<\/a>, and find out.<\/p>\n","protected":false},"excerpt":{"rendered":"NFC West contenders open their regular seasons when the San Francisco 49ers battle the Los Angeles Rams in…\n","protected":false},"author":2,"featured_media":891055,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[436],"tags":[121948,308709,308708,6359,49,48,1749,514,308710,308711,123410,948,82],"class_list":["post-891054","post","type-post","status-publish","format-standard","has-post-thumbnail","category-nfl","tag-49ers-rams-odds","tag-49ers-rams-picks","tag-49ers-rams-prediction","tag-betting","tag-ca","tag-canada","tag-los-angeles-rams","tag-nfl","tag-rams-49ers-odds","tag-rams-49ers-picks","tag-rams-49ers-prediction","tag-san-francisco-49ers","tag-sports"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/891054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=891054"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/891054\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/891055"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=891054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=891054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=891054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}