The pressure starts on Day 1 for the Cincinnati Bengals when they travel to Cleveland to open the 2025 NFL regular season. Cincinnati failed to make the playoffs last year despite a near-MVP year by quarterback Joe Burrow. The Bengals, who closed 2024 by winning their final five games, will face a Cleveland Browns team that just named Joe Flacco their Week 1 starter. The Bengals are 5.5-point favorites and defeated Cleveland by seven and 18 points in their meetings last year. Should you trust the Bengals to cover with your Week 1 NFL parlay picks?<\/p>\n
NFC East rivals clash when the Dallas Cowboys battle the Philadelphia Eagles (-6.5.) in the NFL Kickoff Game on Thursday, Sept. 4. It has been over a decade since the same team has won the NFC East in back-to-back years, but the defending Super Bowl champion Eagles will look to buck that trend. Which team has value to include in Week 1 NFL bets and which side of the NFL odds should you target? Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model<\/a>.<\/p>\n The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated\u00a0NFL picks<\/a>\u00a0its since inception. The model went 31-15 on top-rated picks in 2024. Anybody following its\u00a0NFL betting<\/a>\u00a0picks at\u00a0sportsbooks<\/a>\u00a0and on\u00a0betting sites<\/a>\u00a0could have seen strong returns.<\/p>\n Now, the model has scoured the Week 1 NFL odds<\/a> and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you’d be looking at a massive payout of nearly 25-1. You can only see the model’s Week 1 NFL picks at SportsLine<\/a>, and new users can also target the\u00a0DraftKings promo code<\/a>, which offers\u00a0$200 in bonus bets instantly plus over $200 off NFL Sunday Ticket<\/a>:<\/p>\n Top Week 1 NFL picks<\/p>\n After simulating every game 10,000 times, the model is high on the Washington Commanders<\/a> (-6, 45) to cover against the New York Giants<\/a>. Washington reached the NFC Championship Game last season. The Commanders had won seven consecutive games going into that game behind Jayden Daniels, now in his second season. Daniels was dominant in 2024. \u00a0<\/p>\n He completed 69% of his passes for 3,568 yards, 25 touchdowns with just nine interceptions. In a 45-31 divisional round win over the Detroit Lions, Daniels completed 22 of 31 passes for 299 yards and two touchdowns with zero interceptions. The Commanders won both meetings last season, and the model has them covering in well over 60% of simulations.\u00a0See which other NFL parlay picks to make here<\/a>\u00a0and bet the Commanders to cover here:<\/p>\n How to make Week 1 NFL parlays<\/p>\n The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that it says will not only cover, but win outright. You can only see the model’s Week 1 NFL best bets and NFL parlay at SportsLine<\/a>.<\/p>\n