{"id":906531,"date":"2026-09-23T11:40:17","date_gmt":"2026-09-23T11:40:17","guid":{"rendered":"https:\/\/www.newsbeep.com\/ca\/906531\/"},"modified":"2026-09-23T11:40:17","modified_gmt":"2026-09-23T11:40:17","slug":"cystic-fibrosis-restoring-the-respiratory-protective-barrier-healthcare-in-europe-com","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/ca\/906531\/","title":{"rendered":"Cystic fibrosis: restoring the respiratory protective barrier \u2022 healthcare-in-europe.com"},"content":{"rendered":"<p><a class=\"fancybox content-img\" rel=\"fancybox nofollow noopener\" href=\"https:\/\/healthcare-in-europe.com\/media\/story_section_text\/46357\/image-01-mehdi-badaoui-portrait_hires.jpg\" title=\"Mehdi Badaoui\" target=\"_blank\"><img decoding=\"async\" src=\"https:\/\/www.newsbeep.com\/ca\/wp-content\/uploads\/2026\/09\/image-01-mehdi-badaoui-portrait.jpg\" alt=\"Portrait photo of Mehdi Badaoui\"\/><\/a><\/p>\n<p>Mehdi Badaoui<\/p>\n<p>\u00a9 UNIGE \u2013 Mehdi Badaoui\u00a0<\/p>\n<p>\u00a0&#8220;Using 3D models of cells derived from human lungs, we discovered that prolonged connexin 43 activity alters cell communication, disrupts cell orientation, and progressively disorganises tissue integrity,&#8221; says Mehdi Badaoui, senior lecturer in the Department of Cell Physiology and Metabolism at the UNIGE Faculty of Medicine and first author of the study. &#8220;It then promotes the formation of the anchor points to which the bacteria responsible for respiratory infections attach.&#8221;\u00a0<\/p>\n<p>By blocking connexin 43 activity in their 3D models, the research team was able to restore cell orientation, re-establish the spatial organisation of cells, and prevent the formation of anchor points. &#8220;Mimetic peptides \u2014 short synthetic molecules already used to promote wound healing \u2014 drastically reduced the ability of bacteria to colonise respiratory cells,&#8221; explains Mehdi Badaoui.\u00a0<\/p>\n<p>&#8220;These findings demonstrate that the regulation of cell communication by connexin 43 is a fundamental element in maintaining pulmonary defence,&#8221; concludes Marc Chanson. &#8220;By targeting the deep mechanisms underlying airway dysfunction, our results could offer an additional treatment approach.&#8221;\u00a0<\/p>\n<p>Source: University of Geneva\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"Mehdi Badaoui \u00a9 UNIGE \u2013 Mehdi Badaoui\u00a0 \u00a0&#8220;Using 3D models of cells derived from human lungs, we discovered&hellip;\n","protected":false},"author":2,"featured_media":906532,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[49,48,84,313308],"class_list":["post-906531","post","type-post","status-publish","format-standard","has-post-thumbnail","category-health","tag-ca","tag-canada","tag-health","tag-x-unige_en-brunigeneve"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/906531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=906531"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/906531\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/906532"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=906531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=906531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=906531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}