Eumelanin and feomelanin: the two mammal pigments<\/p>\n
Mammals have only two pigments<\/a>, which are two colours of melanin: eumelanin (dark brown, blackish) and pheomelanin (yellowish, reddish or orange). Redheads only produce pheomelanin, while dark-skinned people accumulate mainly eumelanin. All other skin and hair colours fall somwehere in between, thanks to as many as 700 genes that regulate pigmentation in animals.<\/p>\n In primates, horses, rodents, dogs, cows and many other animals, melanin production and the decision to produce eumelanin or pheomelanin is in the hands of a membrane protein called MC1R. This controls the skin cells known as melanocytes that release melanin. If a melanocyte-stimulating hormone (alpha-MSH) is released, melanocytes start producing eumelanin. If an antagonist, such as agouti-signalling protein or beta-defensin in dogs, comes into play, the production of dark eumelanin stops, and melanocytes produce orange pheomelanin instead. <\/p>\n Three-colour pigmentation patterns in calico cats. Diagram: Lluis Montoliu. However, cats are another matter altogether. Anyone who keeps a cat around the house knows that they are very peculiar animals, very special in every way, and this extends to their pigmentation. <\/p>\n In cats, eumelanin or pheomelanin production is not controlled by the MC1R receptor. Instead, it is in the hands of a locus (whose gene was, until now, unknown) called \u201corange\u201d. A locus is a physical location in the genome whose effects are known (e.\u00a0g. black or orange coat), but not the details of the precise DNA sequence it contains, nor the gene to which it belongs. <\/p>\n For this reason, we usually first identify the locus and then, over time, we discover and describe the associated gene in detail. The orange locus in cats can come in two versions: an \u2018O\u2019 variant that supports the production of pheomelanin (orange), and an \u2018o\u2019 variant that is responsible for producing eumelanin (black). <\/p>\n One detail to note is that the orange locus is on the X chromosome. Female cats are XX and male cats are XY, like all other mammals. And as with all female mammals, all cells throughout development will randomly inactivate one of the two copies of the X chromosome. Oo female cats \u2013 carrying the O variant on one X chromosome and the o variant on the other \u2013 will generate areas of their body that are orange (in areas where they have inactivated the \u2018o\u2019 allele) and others that are black (when inactivating the \u2018O\u2019 allele). <\/p>\n This means that when we see a bicolour (black\/orange) or tricolour (black\/orange\/white) cat, or one of its more diluted versions, we know that it must be a female, and its pigmentation pattern will be completely unique.<\/p>\n Male cats are either orange or black (they have only one X chromosome), but cannot be bicoloured or tricoloured, unless they carry a chromosomal alteration equivalent to Klinefelter\u2019s syndrome<\/a> in humans (where males are born with an extra X chromosome). <\/p>\n Calico cats<\/p>\n Females can therefore have the unique mosaic patterns so prized by cat lovers. When coinciding with another mutation that affects the proliferation and differentiation of melanocytes (producing white patches, without pigmentation), this generates a tricolour cat, commonly known as a calico. <\/p>\n Each calico is unique, as the inactivation of one of the X chromosomes in each pigment cell occurs randomly during development. The earlier this inactivation occurs during development, the larger the resulting spot. The later it occurs, the smaller the spots.<\/p>\n The feline orange coat gene<\/p>\n Until now, we did not know which gene was hidden behind the orange locus in felines. Barsh<\/a> and Sasaki<\/a>\u2019s recent work has identified that it is not the cat homologue of MC1R, but a different one: the Arhgap36 gene. Male cats with orange coats, as well as the orange spots of calico cats, carry a mutation in this gene that blocks the production of eumelanin and allows the production of pheomelanin. <\/p>\n These two studies are a wonderful example of good, basic, solid research, which only aims to satisfy scientific curiosity without knowing its immediate applications, and to understand, in this case, why that naughty cat Garfield is orange.<\/p>\n","protected":false},"excerpt":{"rendered":"Garfield, star of the eponymous comic strip created by Jim Davis in 1978, is, like many of the…\n","protected":false},"author":2,"featured_media":91160,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[49,48,316,66],"class_list":["post-91159","post","type-post","status-publish","format-standard","has-post-thumbnail","category-genetics","tag-ca","tag-canada","tag-genetics","tag-science"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/91159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/comments?post=91159"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/posts\/91159\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media\/91160"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/media?parent=91159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/categories?post=91159"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/ca\/wp-json\/wp\/v2\/tags?post=91159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"Three-colour](\"https:\/\/www.newsbeep.com\/ca\/wp-content\/uploads\/2025\/08\/file-20241202-15-zt13vq.png\")
<\/p>\n
\n Diagram created by Lluis Montoliu<\/p>\n