In a clinical trial, those taking a multi-ingredient nutritional supplement known as NOVOS Core showed improvements in endothelial function in as little as 1 hour within taking the first dose.After 6 months, systolic blood pressure was 6.1 mmHg lower in the supplement group compared with the placebo group, based on the adjusted between-group difference.Participants taking the supplement showed a 1.18 m\/s difference in pulse wave velocity compared with the placebo group, which indicates reduced arterial stiffness.However, larger, longer-term studies are necessary to establish whether these improvements translate into reduced cardiovascular disease risk or meaningful long-term health benefits.<\/p>\n
Blood vessel health markers, such as endothelial function, or the ability of blood vessels to regulate blood flow and respond to physiological demands, and pulse wave velocity, a measure of arterial stiffness, can provide important insights into cardiovascular health. <\/p>\n
Now, the results of a 6-month clinical trial suggest that a nutritional supplement designed to target multiple biological processes associated with aging may improve certain measures of cardiovascular health, such as blood vessel function, arterial stiffness, and systolic blood pressure<\/a>.<\/p>\n The study, published in European Heart Journal Open<\/a>, investigated whether taking NOVOS Core<\/a>, a multi-component supplement containing 12 vitamins<\/a>, minerals, amino acids, and plant-derived bioactive compounds, could influence markers of vascular health.<\/p>\n Participants taking the supplement showed improvements in blood vessel function and blood pressure compared with those receiving a placebo. However, larger studies are needed to determine whether these changes translate into long-term health benefits.<\/p>\n The randomized controlled trial was led by researchers at the University of Surrey in the United Kingdom. It involved 61 participants, with 33 assigned to receive NOVOS Core and 28 to receive a placebo. Participants took their assigned supplement once daily for 6 months.<\/p>\n The manufacturers of NOVOS Core state that it is a multi-component supplement developed to target several processes associated with aging simultaneously. NOVOS Core includes 12 bioactive compounds<\/a>:<\/p>\n Aging involves multiple interacting biological processes that can affect<\/a> the function of organs and tissues throughout the body. Changes in these processes may also contribute to cardiovascular problems, including<\/a> reduced blood vessel flexibility and impaired blood pressure regulation.<\/p>\n \u201cI think the most interesting finding is that targeting several biological processes associated with ageing simultaneously was accompanied by measurable improvements in several complementary markers of vascular health,\u201d study author Christian Heiss<\/a>, FESC FRCP FRSM, Professor of Cardiovascular Medicine at the University of Surrey, told Medical News Today.<\/p>\n \u201cAfter six months, we saw improvements in endothelial function, arterial stiffness and systolic blood pressure compared with control. This provides an initial proof of concept that a multi-component approach may influence vascular aging, although this was a relatively small study and we measured biomarkers rather than clinical cardiovascular events.\u201d As such, the researchers investigated whether the supplement could influence three measures of vascular health: endothelial function, systolic blood pressure, and arterial stiffness.<\/p>\n Improved endothelial function<\/p>\n The supplement group showed improvements in flow-mediated dilation. This measures how well a blood vessel expands in response to increased blood flow. The researchers detected a change within 1 hour of the first dose, while measurements in the control group remained largely unchanged.<\/p>\n These findings suggest that the supplement may influence blood vessel function, although the study does not establish which ingredients were responsible for the observed effects.<\/p>\n Lower systolic blood pressure<\/p>\n The researchers also observed a difference in systolic blood pressure between the two groups after 6 months. The adjusted difference between the supplement and placebo groups was 6.1 millimetres of mercury (mmHg), favouring the supplement group. A difference was also observed within an hour of the first dose.<\/p>\n
\u2014 Christian Heiss, study author<\/p>\n